2XWU


Conserved Protein Domain Family
Importin_rep
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pfam18773: Importin_rep (This model is not part of the current CDD release)
Importin 13 repeat
Importin 13 has a spiralic structure containing repeats structurally similar to HEAT repeats. It serves as receptor for nuclear localization signals (NLS) in cargo substrates, mediating docking of the importin/substrate complex to the nuclear pore complex (NPC). It contains several repeats structurally similar to the HEAT repeat . This Pfam entry represents a single repeat unit.
Links
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Statistics
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PSSM-Id: 523440
Aligned: 10 rows
Threshold Bit Score: 78.9657
Created: 20-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
2XWU_B        402 QFPSDEEYGFWSSDEKEQFRIYRVDISDTLMYVYEMLGAE 441  human
KOF80503      239 QYPPDQEYNSWSTEQKEQFRCYRHDIGDTMMYSFTILKDF 278 
PIK44010      402 QYPSDKEYTSWTLEEKEQFRCYRQDISDTFMNCFSLLHEP 441 
XP_013399867  397 QYPSDEVFAGMNNEEKEQFRCYRQDISDTMMYTYGILRES 436 
XP_008198199  414 MFPLNED-GDWSLDDKEVFRCYRQDIADTFIYCYNVLNLE 452 
XP_018334256  414 qYPGSWEESGWSLDDQEVFRCYRQDITDTLMYCYNILNVE 453 
ORX90935      411 EYPSEEEWSSWSKDVRERFKIYRRDVGDTLINSYLVLHGE 450 
XP_694685     385 CFPRDEDFTAWSADDKEQFRTYRVDISDTLMYTYELLGPE 424 
XP_009055792  389 QHPDDKEYASWTADEKEQFRCYRQDIGDTMMYAFNILQEP 428 
XP_002128195  392 KYPQDNSHNEWTADEKEQHRIYRIDISDTLMYLLEMLHTD 431  vase tunicate
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