Conserved Protein Domain Family
HEPN_DZIP3

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pfam18738: HEPN_DZIP3 
DZIP3/ hRUL138-like HEPN
DZIP3/ hRUL138-like HEPN nuclease. Fusion to TPR, Zn-ribbon, RING, Ankyrin, CARD, NACHT ATPase, DEATH and LRR in various animal lineages.
Statistics
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PSSM-Id: 497487
Aligned: 59 rows
Threshold Bit Score: 116.927
Created: 19-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_013408071   32 GKTLGEL--FAANRTL----LDDLyrglhghRKL--LYESQYKKIFPP---SNQd--pELKEFDITLLFLLTRQLHpqGP 98  
XP_013399167  141 TRQLQAF--LEKPQNLsvlkVLRN-------NNV--LTEKQFSILCPS---SGSi---NIQDMDLSLLYILVKNIA---- 199 
8_pfamImport    1 PDKLQVV--LNNNKAK----LQKLr-----rKGV--IFKKQWEMLFPT---SGDp--pDSEKFDITLIHLLLREIC--HL 60  
3_pfamImport    1 PSTLQIM--LNNNKVA----LANL-------KRRhkLYDNQWEKLFPL---SGDp--pDSNTFDITLLHLLLRNICp-AL 61  
PFX27910      159 QSTIQKIpvLALVHNV---------------Q----PEPKSRDSSGSS---VGDp--pDSNTFDITLLHLLLRKVCp-AL 213 
PFX14414      155 TRDVGEIshKNNKRTLd--dLKNK-------KRV--LNGNQWEKLFPP---SGDp--pDSKTFDIILLHLLLRNICp-AL 217 
PFX14411       40 PSTLQIM--LNNNMATl--vNLQR-------RRI--LNDNQWEKLFPP---SGDp--pDSNAFDITLLHLLLRKICp-AL 100 
1_pfamImport    1 LSTLQIM--INKSKAT----LANLr-----sRRK--LYDSQWEKLFPP---SGDp--pDSNTFDITLLHLLLREICt-VL 61  
XP_013387175   35 GETLEQF--LTRNKQNiw-dCYKR-------KKV--IHKSQYELLFLPnilHTP----KLDDLDVTLLCFLIR-QF--HP 95  
XP_013386931   39 GTSLQQF--LSSNRVI----LEGMl-----sKRK--LNKTQFDLLFPP---GGTmpatCLNNFDITLLFSLIRDLHpkTS 102 
XP_013408071   99 SIPpPKnnVWNDPndQwHS---QHnvPTKTQAIIL-IKYERNKLAHRTTTDMEETDFECLWNRLSSAIVEVGGM-SQEEV 173 
XP_013399167  200 ----LKdaDWSTL--S-NQ---DD--SSPEHDVIR-IKDLLHRLSAVGPNNIQVERFETIFNDLSDPLRRLGGN--P--- 261 
8_pfamImport   61 AAP-ST--GWHIM--P-AD---DD--SSPEANITR-IKCFRNELlHVVSTGIPNNEFEIKWSKISSAIESLEISiQRNKI 128 
3_pfamImport   62 TKP-AK--GWDEM--P-AD---TD--HSCQAEITR-IKYFRNELCHSNSTSVPNVEFEDKWNTVSQSLVALGLD--QLEI 127 
PFX27910      214 TEP-AT--GWNEM--P-AD---AD--HSREAEIAR-IKYFRNRLCHSISTGVPNDEFEDKWNTISPSLVALGVD--QLEI 279 
PFX14414      218 KKP-ST--GWHEM--P-AD---TD--HSREAEIVR-IKYFRNSVSHNFSTGVPNDEFEDKWNTISHSLVALGVD--QLEI 283 
PFX14411      101 IEP-AT--GWNEM--P-AD---TD--HSQEAEIVR-IKCFRNSLCHSISTGVPNDEFEGKWNTISHSLVALGLH--QLEI 166 
1_pfamImport   62 IEP-AT--GWHDM--P-AE---TD--HSREAEIVR-IKCFRNSLCFSISTGAPNDEFEDKWNTISFSLVTLGID--RLEI 127 
XP_013387175   96 NVP-VTwyGWSC---PdKAkakADplMTPEIEAIInIKYHRNQLAHRGTTVVKDQEFEKMWNTIAPSVVTLGVE------ 165 
XP_013386931  103 DVPePKsdVWNNLqaA-RS---SPdlPRQILDLIE-IKFYRNSLAHSKSVNITDSDYELMWQSITISVLNLGVT--TEQL 175 
XP_013408071  174 TELH-DKAIEPEREAIY 189 
XP_013399167  262 EYILqTECSTGEKEDAK 278 
8_pfamImport  129 QTLK-TNPIDHETQQYL 144 
3_pfamImport  128 DSLK-TQDIDYDTQRRI 143 
PFX27910      280 NCLK-TQDIDHGTQRRI 295 
PFX14414      284 NCLK-TQDIDHGTQRRI 299 
PFX14411      167 DCLK-TQDIDHGTQRRI 182 
1_pfamImport  128 VRLK-TENVDYGTQRRV 143 
XP_013387175  166 KPVVeEARMEVIGIQHY 182 
XP_013386931  176 DSVK-NITIDPEKEQEY 191 
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