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Amino acid:DNA transferase This entry represents the alpha-helical domain of the glycinyl, putrescine and serinyltransferases (grouped as amino acid:DNA transferases, formerly known as alpha-putrescinyl/glutamylthymidine pyrophosphorylases (aGPT-Pplases)) which catalyze thymidine hypermodifications in the viral genome, transferring glycine, putrescine or serine to 5-phosphomethyl-2'-deoxyuridine (5-PmdU) to produce Nalpha-GlyT, Nalpha-PutT and O-SerT, respectively. These modifications probably prevent degradation of the viral genome by the host restriction-modification antiviral defense system.
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