Conserved Protein Domain Family
ADDT

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pfam18724: ADDT 
Amino acid:DNA transferase
This entry represents the alpha-helical domain of the glycinyl, putrescine and serinyltransferases (grouped as amino acid:DNA transferases, formerly known as alpha-putrescinyl/glutamylthymidine pyrophosphorylases (aGPT-Pplases)) which catalyze thymidine hypermodifications in the viral genome, transferring glycine, putrescine or serine to 5-phosphomethyl-2'-deoxyuridine (5-PmdU) to produce Nalpha-GlyT, Nalpha-PutT and O-SerT, respectively. These modifications probably prevent degradation of the viral genome by the host restriction-modification antiviral defense system.
Statistics
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PSSM-Id: 497477
Aligned: 14 rows
Threshold Bit Score: 179.916
Created: 19-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
YP_009833024  44 GELNQQLRLMDWAIEKRWTnd--hILESKLWLAFLWGCCYNFTG-PWVIL--NAFPVPP---------TEPGGMQKFADW 109
WP_013365099  67 PNSNMFDPIKAAVIMKKNG-----NIDEACWLTFLAIHFGKHSKyKWSLVk-GVYGSLGsgfv-wawdNVITYPNDFMQW 139 [Enterobacter] ...
WP_014429198  68 PKSPLFDPIRAA-ITLSAK-----QTEEAFWLVFLATHCGRNLRtAWQLAa-ELYGSSElvpw--twaRVLVDPKSYIDW 138 Rubrivivax gela...
WP_068005054  68 PHSSMFDPIKGAIHLTRNG-----DYDGAVWLAFIQTHFGKHADdGWKLAa-NVYGSFGggpv-wdfsTYGANLGGFLEM 140 Pseudovibrio ax...
WP_087467637  67 PYVSNFNPLKAALYHFKNN-----NLDEAVWLIFISTHFGKSKKsGWLLTq-DFYKGPNqnsi-ltweRVKLGSLETTTW 139 Cellvibrio sp. ...
WP_012384534  66 PNYPSFDPERAVAFHMQQG-----DVNEAGWLVFLMTHFAR-PLsGWQRLk-DVYGQLGsgkw--dwaTVITNPTAFYNW 136 Beijerinckia in...
Q0RM58        13 VTTRDIDPVYPVLRHVIRAag--lDRDQAVWLVVLh----------------VAYYQLGsalaawgaqPVPGGPRPGLLT 74  Frankia alni AC...
YP_009222564  10 DHTGDWRKFANQMFKLEDA--------DPGYMLLRRADLPLAQKlRYVLAw-CTFYNPGla-----arASDFQGAKFYEF 75 
YP_009098881  52 VLTHDLDHIHYYKYLCKDY-----DFEQKAWFAFC---FGMTYRtPQAFAytETFPDFH-----------AINMNELEKW 112
YP_007237512  48 EEHNQQMRLMDYAIEVTEGitdaqKIERKIWMSFLWGCCYNAIG-PWTIYs-E-FPVPP---------QSKEEMQRFADW 115
YP_009833024 110 YNKNFERI-------RFDTDCRYR------KSKMIACVQSYVDWLNLHGGGDQWSAIEE-TMNlRDPVAkYEKLWEVANS 175
WP_013365099 140 LIFNHFQLas---qgAFGNHRKYEslnparKNWNGAIIQSYIDWVRLFGDHKTMLFRFEkDYP-NKKER-FRALYKSMDK 214 [Enterobacter] ...
WP_014429198 139 IEGHYETFg-----gKFGNHRKYEslk-pgPKGTGAIVRSYVDWIAGYGSHAAMVGQARaHAD-GNARRaFGVLYEQMRA 211 Rubrivivax gela...
WP_068005054 141 LQKNTALLnqksvagRFSNHRKYQsk---qPHRIAETFRTYYEWQTQAGGFRDLVQQIHkERG-QHPAEaFDGLYKSMRG 216 Pseudovibrio ax...
WP_087467637 140 IDNLKSHLankapkrVFGNHRKYEslrpdsKRPLNKVIASYISLIESHQTHENLFSLALiDAE-GSKYNlFDNLYKKFRA 218 Cellvibrio sp. ...
WP_012384534 137 LDANWQGIg-----gGFGNHRKYEslrpnaKRPMKKAVSDYLTWI-GPGGHAAFFANAVrEAG-NDPHTiFDYLYQNLN- 208 Beijerinckia in...
Q0RM58        75 LPT--------------GTERRAHr----dVRQFARHWAGLLGAFDRHGGPAGWL---------DAGGAdWRRLNEHVAQ 127 Frankia alni AC...
YP_009222564  76 LRYVYPHAk-------rASERRHF--------RGQSGLKALAQWQSLYPKPEAMIEACF--------ASsYLQVRKNMSH 132
YP_009098881 113 HANNWKRT-------TYGTDARYN------KGHWVSQVQSVKNWLGK-SSFKDKFDSIL--VG-SSQREnFWLLYREIQT 175
YP_007237512 116 YNLNFERM-------RFDTDCRYR------KSKMIPCVQSYIDWLRGRTQMDAFRPMLEl----DIPVHqFTNLWDTVMS 178
YP_009833024 176 WAYY--GRLSAWNYLEAVGLV-TEWKYGLDCqdFLlTD---VSGSes--nRNGVAFITDnehlltkhgkLKSTGEtIKQe 247
WP_013365099 215 VLRF--GRTAKFDFLTMLEKLsITDIEADST--YM-SE---ATGP-----KRGANLLFG----------GTTLDV-FSS- 269 [Enterobacter] ...
WP_014429198 212 VLRF--GRTGRFDYLTMLGKVgLADIEADST--YM-NE---ATGP-----KRGAKLLFD----------GQIDSK-TRA- 266 Rubrivivax gela...
WP_068005054 217 VAGFgqGRLGRFDFLTMLGKLdLAPIEPGSV--YL-DK---ATGP-----LAGARLLFF----------DNRDYN-ITG- 273 Pseudovibrio ax...
WP_087467637 219 VLSF--GRTGSFDFLTMLGKLkILNAEPPKT--YI-NQ---STGP-----RDGCGLLFG----------NKSS------- 268 Cellvibrio sp. ...
WP_012384534 209 VLTF--GRLAKFDYLSLIGRYgIAPIKAGSA--YL-DG---ATGP-----GRGARQLID----------GNPTSA-TSN- 263 Beijerinckia in...
Q0RM58       128 VEGN--GRWAAYKTAELAQKVlDVPTVVADA--GH-AH---STGP-----RRGLALLYPr---------LPAGNRpVDI- 184 Frankia alni AC...
YP_009222564 133 MAQM--GDYFYWKLADIQDTVmGKPVDFTGCekYM------PKVP-----KQGADMI------------GDMENLfTLEi 187
YP_009098881 176 LHKF--GRMTGWLLMQCLHDLlELPIDPEDI--ML-DGyspNNDSslgsiWNGLCALTNqpekm-igkyGDYQVVqKDVe 249
YP_007237512 179 WKYF--GRLSAWNFLEALNMVf-GNMWQIDVpgFMlRD---RDGSes--nRNGAAFLSNrddwvtkhgkKKINGCpITD- 249
YP_009833024 248 dcLMLNEKAEGLFTMLKenf---ghI---DPvlrFNTETV-FC-WVKkrFRETN 293
WP_013365099 270 --EQLEKWIAELDLYLN--------V---GM---QVIEDS-LCnWQK--SPNKF 304 [Enterobacter] lignolyticus
WP_014429198 267 --KTLEARVAVLERHLG--------V---GM---QVMEDA-LCnWQK--SPNSY 301 Rubrivivax gelatinosus
WP_068005054 274 --KVLQSRVDSLDAYLQ--------T---GK---QVIEDS-ICnWQK--SPERF 308 Pseudovibrio axinellae
WP_087467637 269 --AEYENEMFKLSESLS--------InpfGM---QVLEDA-ICnWQK--SPDAY 306 Cellvibrio sp. PSBB006
WP_012384534 264 --ANLQATLDALDQQLN--------V---GM---AVMEDA-LCnWQK--SPRRF 298 Beijerinckia indica
Q0RM58       185 --QVLDRYTRRLARR----------L---GEadiGQVETS-LCdLHSltRGHYY 222 Frankia alni ACN14a
YP_009222564 188 imGVVTAHVSKLAYP----------VkegRKlalQEAETV-CCvFKQhvVGDYK 230
YP_009098881 250 waKDALLEYTSIAEEFS------------GFridSFRKESiYCqYKRmfAPDGS 291
YP_007237512 250 --EECDILEADLEQAFQdcvaefghL---TFinrLNFETSgAC-WLKkfFREKN 297
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