Conserved Protein Domain Family
HMUDK_hel

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pfam18723: HMUDK_hel (This model is not part of the current CDD release)
5-hmdU DNA kinase, helical domain
This entry represents an alpha-helical domain found in 5-hmdU DNA kinase (HMUDK), a P-loop nucleotide kinase that phosphorylates 5-hydroxymethyluracil (5hmdU) into 5-phosphomethyl-2'-deoxyuridine (5-PmdU) on DNA as a step in the pathway leading to thymidine hypermodifications in the viral genome. HMUDK also transfers glutamate to 5-pyrophosphoryloxymethyldeoxyuridine (5-PPmdU) to produce 5-Nalpha-glyutamylthymidine (Nalpha-GluT). These modifications probably prevent degradation of viral genome by the host restriction-modification antiviral defense system. Members of this entry (formerly known as aGPT-Pplase1) are found in phages with hypermodified bases and eukaryotes such as fungi and stramenopiles.
Statistics
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PSSM-Id: 523427
Aligned: 60 rows
Threshold Bit Score: 242.476
Created: 19-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
YP_008532082  27 PFHRKLSYEWMSERYKIHVRKdVQRLPS-P-WTENEILRQVKFCNVRREHDRQSQHLIRNIVENNNLSLADKMFNCLLFR 104
KIP10009      59 LEMIAILFKFVCERHAIQQRR-LAGLAP-P-WTRDEWLQNYPFTNVFRVLDRNSQFILLRVIGDSPDNIQDAVFRVLLFR 135
PSR76148      55 SELFSTYFQFVAERHQIFLRR-YDGQPQ-P-WTDDPILAAYPFTNVFRVLDRNSQYILQNVIQKGSQDLHEAFFRVLLFR 131
KZT26800       1 SAVFDTLFYWMAERDAIRRRK-LAGEAA-P-WTKDHILCEYQFTNVFRVFDRTSQYILRKVINQGSQDVYETCFRVMLFR 77 
KZT21621      38 SPVFDTLFLWMAERDAIRRKR-VAGEPA-P-WTDDPIFSKYRFTNVFRVFDRTTQYILKNVINRGSTDLNECAFRVMLFR 114
GAC75570      84 EEVLRTFFQYSHDRHDVFLKR-KQGKPQ-EeWTDDPVFKSTKFANVYRVLDRLTQYVLTRVVQDGPQQLEEVCFRVLLFR 161
KDQ10921      22 TSHLDTFYNFVAERHRAFKRR-VAGGPP-P-WSTDKGVAGRKFCNVFRIYDRVTQVLLHEVIEAGPQEHAEVCFRVILFR 98 
OCF56042     280 NHWVYLFFRFCAERHKMYNRR-LAGVPRdQ-LTEDETMSKVHIGNVYRQLDPSSRNIRENIIGKGDQTPQEVCFRLFLYC 357
XP_021871032  73 EYWVFLFFRFCAERHRMQVRRtYEGVAReA-LSQDETMQKTFVGNVFRELDAGSVRNRELIIGKGDQSHEEICFRIFLFC 151
CUA70342     162 SPMLDTMFYWIHERHELFLRR-LEGHPP-P-WTEDTILRNHRFTNVSRTYDRATQFLINRVINVGDQSHHELFFRTVLFR 238
YP_008532082 105 MFN---MWDPIQH-VLEGPvSINDFrnINlDRTRERFADFDKK-GGVTFTNAFNTGGlkqclaFPElavtgkpaspskmm 179
KIP10009     136 MFNkieTWELLEQ-HLGKIt-FQGF--DT-RAYCRIFETA----GVTLYNAAYIIPA------PKL-------------- 186
PSR76148     132 TFNkieTWEFLEE-NLGAIt-WKDF--NL-QTYDRVLSSVDGA----VYNSVYIMPA------PGRa------------- 183
KZT26800      78 TFNrisTWELLDS-ELDLT--WSNF--NF-NAYCRVLSRADAP----LYGHAYILPA------PNA-------------- 127
KZT21621     115 TFNrisTWELLES-SIGAL-TWKAF--DF-DTYKEVLGEAVRD-GQALYGYAYIIPA------PSL-------------- 168
GAC75570     162 SFArisTYEVIRT-ALGGPpTLANF--SP-TAYENFLMPHISA-GNPVYGSSYFIPA------PRE-------------- 216
KDQ10921      99 LFNrpdTWKLLNK-ELG-PlSWKTF--NI-QDYTDVL----SE-RESLYTGAYILPP------PMKl------------- 149
OCF56042     358 MFYnesTWNELCSvSTGGLpTWQHYvtDL-PAYEGVLYRLSMVeKKKIYYGGFQLV-------PPTiy------------ 417
XP_021871032 152 AFYkmeTWNALEG-ALGHVpRYSTFekDL-PIYEATISDLSRR-RRKIYTGAFQLV-------PPTpy------------ 209
CUA70342     239 LFNrisTYEYLER-RCGPL-TIANF--NI-PRWSAALTKLQNQ-GNSLYTGAYQINW------PNF-------------- 292
YP_008532082 180 vkvyrrgigvVdvlpykvAKQmvedHPGEYsiegwephmgMRVVRFLksfvthNPHFFHSLLGFNSPLSVYEELRDkVEG 259
KIP10009     187 ----------G-------YNS----NYENH----------LRLIEAMm----nDGDLTGDLLQCKHIRDAHVRLLR-WPS 230
PSR76148     184 ---------fG-------FDR----NYLNH----------LRLIDLMm-----AEKLADELQQMKHLKDAHGRLTL---G 225
KZT26800     128 ------------------FGKk--rNYQNH----------LLLLRHMl-----EDGLPEKLMSAVSMREAQSIIST-YIG 171
KZT21621     169 ----------G-------MSR----NYENH----------LLLLQRMm-----EDHLPEKLKEVKHIEDAHRIMIS-YPS 211
GAC75570     217 ------------------FRTk--yPYQST----------LRLVHLMm-----RTGLPRRLADLHHMRDAHALLTS-FPS 260
KDQ10921     150 ----------G-------RPR----GFENS----------LRLVQLMme---lN--LPGELAKCGSMREAVDLVKA-FPS 192
OCF56042     418 ---------fTdn----rNRNkdmpHFAAS----------LRLVLAIm-----LTSLPTKLLECSYAVDASYLLQT-IPT 468
XP_021871032 210 ---------fG-------AP-----HFAAS----------LRFVLALm-----QMGLPAKLLSCHYAVDASNILRT-VPT 252
CUA70342     293 ----------G-------AETankpSHEKH----------FILIKHMl-----KDRLPEKIRRYTRLQDAFDSILA-YPS 339
YP_008532082 260 LGP--FLA---YQVWVDFTYNLDYPFSENHFTIAGPGCRAGIDLLFLDk----DGMTHE-ECIFWLRDNQDQVYGQYGy- 328
KIP10009     231 MGN--FTA---MQILLDLNMLSYFNWSEDEWVELGPGSKSCLRKIFPNl----NVSAHAqEALRYLRDHQWSWYSTVGa- 300
PSR76148     226 VNEifTPVldfFRLILDLNMMPHFNWSEDEWVAVGPGSKSCLHKMFGS-----DVAGHEeAAMRFIRDEQFKYFKKYGv- 299
KZT26800     172 MGP--FLS---FQLLLDLNMSAHFHFSEDEWVICGPGAEDGLRKIFGD-----AVKGIElEVMKYLRDTQFDHWARLGit 241
KZT21621     212 MGD--FTG---FQLLLDLNMIPHYSFSEDEWAICGPGSAAGLRKIFGD-----DVKGIEtAAMVYLRDTQNEHWERLDis 281
GAC75570     261 LGP--FLA---MQLLLDLNLSDHFDFSEEEFAACGPGSKQCLVDIFGK-----YVSGFElEAMRWIQKEQEHYWAKYGit 330
KDQ10921     193 MGD--FLA---YQLVLDLNMTPHLSFTENEFAVCGPGSKSCLESIFGD-----HVRGIEeDAVRWLVATQREHWARLGi- 261
OCF56042     469 FGG--FLS---LNILCYLNDTSNYTWYYRNFATCGPGPRSYLGRIFGGksvinSLPMEEaGLV-WLYEHQWKYWTRIGe- 541
XP_021871032 253 LGG--FLS---LNMLCYLNDSPHLSFSYRNFASCGPGSRAFLRAMFGPc---iNSTAYEeAGLHWLQKNQWQYWAALGe- 323
CUA70342     340 CGQ--FIS---YQLALDLNMLPEVHYDQDTWAPVGPGSMRGLLKMFGP-----GVKGIEnEAMLYLLGIQAQHWHRLGvd 409
YP_008532082 329 -VREQfwsaeapeDQCMNVMQLENMFCELSKYTR-CAEAVMR 368
KIP10009     301 tQDQIprls-aerPRGLSMVDIEHSLCECEKYSR---GKLQH 338
PSR76148     300 dTVEIprlc-perRPGLTMVDIEHSLCECEKYSRaRFPELKG 340
KZT26800     242 dLPRLye-----gRTGVTLVDLEHSLCECEKYSRvKHPSIKG 278
KZT21621     282 ePPSMhp-----gKIGVSLVDLEHSLCECEKYSRvKHPSIKG 318
GAC75570     331 dVPHLcp----arKPGLNVVDIEHTLCEVFKYRR-ARGRMEA 367
KDQ10921     262 --tDPpsmy---eegGLSMVDVEHALCECAKYIReSSGRSKA 298
OCF56042     542 dPPRAeel---glRPGMRVLDIENALCWCHRYi--NAYEKKG 578
XP_021871032 324 dPPHAwel---gvRPGVRVLDIENALCWCHRYVK----DYLR 358
CUA70342     410 pDRPIhgp--glcPPKIGLPEIEHGLCEVDKYSRmRHPNIVL 449
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