2M9U


Conserved Protein Domain Family
MLVIN_C
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pfam18697: MLVIN_C (This model is not part of the current CDD release)
Murine leukemia virus (MLV) integrase (IN) C-terminal domain
This is the C-terminal domain (CTD) which can be found in murine leukemia virus (MLV) integrase (IN) proteins. The MLV IN C-terminal domain interacts with the bromo and extraterminal (BET) proteins through the ET domain. This interaction provides a structural basis for global in vivo integration-site preferences andt disruption of this interaction through truncation mutations affects the global targeting profile of MLV. The CTD consists an SH3 fold followed by a long unstructured tail.
Links
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Statistics
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PSSM-Id: 523412
Aligned: 7 rows
Threshold Bit Score: 90.3098
Created: 19-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
2M9U_A         10 VGDTVWVRRHQTKNLEPRWKGPYTVLLTTPTALKVDGIAAWIHAAHVKAADP 61   Moloney murine leukemia virus isolate Shi...
EHB15683      169 SGDWVFVRQHQQKDLEPHWKGRYVTVLTMPTTLKVDGIASWVHYTHVRPVDP 220 
EHB17156      158 PGDWVFVQRYRQKNLEPHWKGPYVIVLTTPNALKVDGIASCIHYTHARPADP 209 
1_pfamImport    5 PGDWVYVHHHRQETLEPRWKRPFLVILATPTALKVDSISAWVHYTHTRPADL 56  
P03355       1659 VGDTVWVRRHQTKNLEPRWKGPYTVLLTTPTALKVDGIAAWIHAAHVKAADP 1710 Moloney murine leukemia virus isolate Shi...
EGV97740       52 IGDSVYIRRHQSKTLEPRWKGPYTVLLTTPTALKVDGIAAWVHASHAKKANT 103 
EHB15633      168 PGDWIFVRRHRQKDLEPRWKGPYVTVLTTPTALKVNGIASWVHCTHVRLADP 219
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