5KDW


Conserved Protein Domain Family
IMPa_N_2
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pfam18650: IMPa_N_2 
Immunomodulating metalloprotease N-terminal domain
PA0572 of P. aeruginosa is an inhibitor of PSGL-1, also known as an immunomodulating metalloprotease of P. aeruginosa (IMPa). IMPa prevents neutrophil extravasation and thereby protects P. aeruginosa from neutrophil attack. It belongs to the peptidase M60 family pfam13402. This entry represents the N-terminal alpha/beta-fold domain.
Links
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Statistics
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PSSM-Id: 497417
Aligned: 10 rows
Threshold Bit Score: 236.924
Created: 19-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
5KDW_A        44 LLDGLY----QNLSQAYDPGAASMWVLPANPDNTLP------FLIGDKGRVLASLSLEAGGRG-LAYGTNVLTQLSGTNA 112  Pseudomonas ae...
WP_058721115  94 VLGSLYsaggKALDLTLNHSSDSITISPISRVEAMP------YIVSDNGSGMAALVEVGPGRA-MAYGADVLAWMAGTTR 166  Paucibacter sp...
WP_161805161 115 ILANIYgnssVVPSLAFNLGTNSSDITPRASTTAMT------LVSADDGSSLAAISNVGNGRA-LAYGADVLVWMAGTTK 187  Amantichitinum...
WP_261340409  84 ILGD------DAASLVLNHSTNSTTVNVAKSSLAAP------LLSADSGAGMAAISMIGAGRG-LAYGANVLAWMAGTSA 150  Paucibacter sp...
WP_009501804 150 ILTDNG----KTLNLQFQGINDSNTLQAADPFVSRN------VLTSDSGVPISSLSIKNDARF-LGYSLDILAKIDKSHK 218  Moraxella macacae
Q9I5W4        84 LLDGLY----QNLSQAYDPGAASMWVLPANPDNTLP------FLIGDKGRVLASLSLEAGGRG-LAYGTNVLTQLSGTNA 152  Pseudomonas ae...
EKE77908      57 ALAMTL----LDAPLRYAPGRYSQFMEPAGKDSFPL------LLGRKTGKPMAAAGVSQAGRRyLAFGTVPVTYEFEp-- 124 
WP_008484773 159 LVTQLF----GNGAIDYAPGNRTQLFNVTEPDRTFS------LINANGGQVLAIAGEVQGGRY-GGIGTHLFARFQAGEL 227  Gallaecimonas ...
WP_012323693 171 FLQSIY----QGNSIRYDSGQHSQMIRLNQAAHYYPqsksfeLIRGNGGRIFAAASDKNGQRN-AAFGTDIISSMQQGNN 245  Shewanella woodyi
WP_012154160 167 LLESIY----KNDTVEYDQGRHSQMIQLAGAEHAYPqnkayaIVTGNKGLTFAATNDKAGQRN-AAFGTDIISSMQQGHN 241  Shewanella pea...

5KDW_A       113 A--HAPLLKRAVQWLVnGDPGAATAKDFKVS---VVGVDKTAALNGLKSAG-LQPADAACNAlTDAS-CASTSKLLVLGN 185  Pseudomonas ae...
WP_058721115 167 EqqHLPLFTRAFTWTLtGAAEGSLPATLKYA---VAGYNSSTVKSFITRLG-KTAQDTACAI-ATDNsCWQAADLLVFGA 241  Paucibacter sp...
WP_161805161 188 EqqHYPFFRRAWGWLLtGNANSTLPANVRYA---TAGYTAANVKTLIERTG-STATAITCDLtSPSNtCWNNADVLVFGG 263  Amantichitinum...
WP_261340409 151 QqqHLPIFRRAMNWVItGDANGTLPAQVRVG---VGGYDGSTVKQYLTRVG-STGVVSSCAVaDPANtCWRQLDLIVFGN 226  Paucibacter sp...
WP_009501804 219 E--HAPILKRGINWLIsGNANTDLKQKQKLTi-aYAGYDSKKINNYFKTTYnITPTLLSCDLfKEDShCWQQADLLLIGS 295  Moraxella macacae
Q9I5W4       153 A--HAPLLKRAVQWLVnGDPGAATAKDFKVS---VVGVDKTAALNGLKSAG-LQPADAACNAlTDAS-CASTSKLLVLGN 225  Pseudomonas ae...
EKE77908     125 ---FHKNLEELVGWLLsGEPGFVYKPGAVIAt-aFLGTQDKKVSSWLRRNM-KDVAVVQCEV-LGLKeCLGAADLVVLGA 198 
WP_008484773 228 La-MAPAAEQLLAWLM---QDADLSQPHTLAlsfLAGQE-EATRQWLEAQH-PNWTLLGCSDvAALDnCLAQADLVISGW 301  Gallaecimonas ...
WP_012323693 246 Ld-YQENFKGLLAWLL--DKELAQAQTQEVRlflMGGSTVSRITAWIATQY-SNWNVTLCDDkAAQSsCLNQADLIITGS 321  Shewanella woodyi
WP_012154160 242 As-FEPSFKRLLGWML-AQDQTALAEPKQIRlflMSGNTVNRINSWIELHY-PNWQVETCSDeATLSsCLAEAQLVLTGS 318  Shewanella pea...

5KDW_A       186 G--ASA--ASLSATVRARLQAGLPILFVHtNGWNQSSTGQQILAGLGLQEGPYGG--NY 238  Pseudomonas aeruginosa PAO1
WP_058721115 242 Gv-ADD--GRLQARVASYLAAGKPVIYMH-PNWINSDPGRAVLAAMKMEMGGYPG--NY 294  Paucibacter sp. KCTC 42545
WP_161805161 264 Sv-ASN--AALQSTVTQYLNAGKAVVYMQ-PGWGDSAGGRQVLAAMGMTLGGYPG--NY 316  Amantichitinum ursilacus
WP_261340409 227 Gv-ADN--PALGNLVRSYQEAGKAVVFMQ-SSWNASNGAQRVVSGMGLSLGGYPG--NY 279  Paucibacter sp. KCTC 42545
WP_009501804 296 ShtKVMdqILLQRLFERYQTAKKPLLYVNgGWWSNNDGRDNFVRQYGIDLQGYAG--NY 352  Moraxella macacae
Q9I5W4       226 G--ASA--ASLSATVRARLQAGLPILFVHtNGWNQSSTGQQILAGLGLQEGPYGG--NY 278  Pseudomonas aeruginosa PAO1
EKE77908     199 Eg-DSAeaKGLVAVLDK--KSALPVLYFHtPYWKESEFARQILASIQLRQGEAGG--NY 252 
WP_008484773 302 Rg-NDQdaAAIVASFQGALAQGKGLFYQHnWYEATSPVADAITELMGASL-PYGG--NY 356  Gallaecimonas xiamenensis
WP_012323693 322 NgdLSE--RDVSTLLTSAQQQKTPLLYMHlHSWNSVPLTQTVLGMMDFSMQGPGGpgNF 378  Shewanella woodyi
WP_012154160 319 SelFTI--ETVAPLIAQIQADKQPILYLHlHSWNSVPLTQTVLNPMGFSMQGPGGpgNY 375  Shewanella pealeana
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