4H5Y


Conserved Protein Domain Family
LidA_Long_CC
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pfam18641: LidA_Long_CC (This model is not part of the current CDD release)
LidA long coiled-coil domain
LidA, another Rab1-interacting bacterial effector protein, is translocated by Legionella into the host cytosol at the beginning of infection, and it localized to the Legionella-containing vacuole (LCV) at the cytosolic surface. It has been shown that tight interaction with Rab1 allows LidA to facilitate the Legionella targeting factor (DrrA/SidM)-catalyzed release of Rab1 from GDP dissociation inhibitors (GDI). The base of the protein is formed by two antiparallel coiled-coil structures forming a long coiled-coil domain. This region of LidA interacts with switch and interswitch regions of Rab1 the nucleotide binding pocket of Rab8a, hence blocking access to the GDP/GTP-binding site to a great extent.
Links
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Statistics
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PSSM-Id: 523387
Aligned: 20 rows
Threshold Bit Score: 146.262
Created: 19-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
4H5Y_A       361 DLATIKMEALIHKLSL---EMEKQLETINDLIMSTDPKE-------------NEE---------ATKLLHKHNGLNLKLA 415 Legionella pneu...
1_pfamImport   1 LPLHAKIDDQIAALTK---KMDINARQIQKLVDLGSMHDgvvdathvrqglaEEEflgtpllevARAKIEDSTADNLHVA 77 
WP_058506836 425 PAERAKIEKGLADLKK---EIAKDMDKIAEEAGTVSPEQ-------------------------TKADIAKVNAKQVEVA 476 Legionella quin...
WP_058447441 389 EDRIEVIESNAAKLDD---QIRTDLKVIHELLQDGDVKK-------------EKQ---------AMAMIQEHQGLVAEMV 443 Legionella feeleii
WP_006870442 229 ALKPEDLDTLIEDLEN---HIHAQTETITTLLESGDPAD-------------EEE---------ARQLLNKQNALNLQVA 283 Legionella dran...
WP_044011789 266 QERVHATQNGLLDIQA---KMAQLTTNILQLANQ---GQ-------------DHE---------ASQLMNHLDGLHIEAE 317 Legionella mass...
WP_058501740 220 NEAITKLQGELDKIAT---EISKKTNQITTLIAE---GK-------------EKE---------VKTALHELDGLHFREA 271 Legionella isra...
WP_028387515 225 LEAMLHAEQALAHFEA----LQLRGDAVNHELTA---GV-------------------------LQNLIASQH------- 265 Legionella gees...
WP_058520369 266 DRKIRMLEERLSFHQTqlqQPPQTSEQLFQQLIDRVRVR-------------LNEpeh---ideSPYRVCEVEGLRLQER 329 Legionella tucs...
WP_028374115 165 EDKIKAIEDEISKLEGtkeERDEKAQAIFKLIDDGLKLG-------------GQEgeem--vaqAKKELEELNAKNLQIG 229 Legionella lans...

4H5Y_A       416 NLQDMLAVHRKE--KSFFNEKGEKVTSLNDAHYVIG---------KDqqlfnlggkfypihkeQKILEKDG--KFYLLKQ 482 Legionella pneu...
1_pfamImport  78 TLKDLKSVLNGD--KVFCNRSGSPVTSLDEAELVLPkdmarmlreEK----------------KQIVEYEG--KYYLIKQ 137
WP_058506836 477 ATEDMLAVYKGE--KSAYKADGTPTSDFNDTAYVAP---------KG----------------KSILKGDDg-SLYLVNK 528 Legionella quin...
WP_058447441 444 TLKDMIAVLKGE--KRLVKKDGTETMSYKEAAYILS---------PG----------------QRVVKDQHg-KSYLLTG 495 Legionella feeleii
WP_006870442 284 SLKDLRSTRQEEnaKKFFNADGIQVPSQKDASFITN---------HD----------------QKIVKKDG--EYYLLKA 336 Legionella dran...
WP_044011789 318 GMQTMLDHAHSK--CHYFTEEGHSTDAYHKAAFIAP---------KD----------------QHIHRDKAtgQLLLLEK 370 Legionella mass...
WP_058501740 272 FLTDLLDVSQYK--KHLFDANGELTNSLTKADFVLK---------RD----------------KKIVEHEG--QYYLINA 322 Legionella isra...
WP_028387515 266 -LAEWHDVVAGN--RCAFDHNWEPCLEAHNAAYILR---------PE----------------LQVVRDGN--TCYLLPA 315 Legionella gees...
WP_058520369 330 GLSQALQILRNE--KILLNPQLERVYDFSQAQFIIDp-------nHL----------------SRYRRYGD--SYAYFSE 382 Legionella tucs...
WP_028374115 230 TLKDMLAVTKGD--KIMYKSNGETTTSFQEADFVVP---------KD----------------KQLVKEGE--EFYLLNQ 280 Legionella lans...

4H5Y_A       483 G-EDWESIKDSPEKQkkAEHDFHKLQyETPMTVKKLVHHNKGLETTIHKERIEETKQQLEDNGKEKIEIANNISK 556 Legionella pneumophila
1_pfamImport 138 G-QDVKDLSVDEKHA--AYEACKSLRpQERATVKHLIQHNNGLEHRENEHHKDIIFQKQQLQIQKIMEFANVVAR 209
WP_058506836 529 DvTDVNSLSASQKQQ--ASSDFNRAK-GQMTSVEDVIKNNRSGEHGLNNQQLGAARQTQQTQLSQLSEMRMQIQK 600 Legionella quinlivanii
WP_058447441 496 H-QSLDNMTPHEKDK--AHDKL-----RSLATIDKLLHHNEKIELGKKRQELKQVHKEIHDLRDQIQFMQQRKAE 562 Legionella feeleii
WP_006870442 337 D-QNIDELSDADKED--AKEGFKSAQ-HELMTVQKAVQHTHKLEKSFFATQIIEVTAQKEQNTAERMTLENQIKL 407 Legionella drancourtii
WP_044011789 371 G-QKPEDMSAEEKAA--AHAKFEQFK-PGFCNARGKVKQYHDTEMRDYENTQKDLVERSEKMQQHILQLTDERNK 441 Legionella massiliensis
WP_058501740 323 D-QDIHTLSQDDKKE--AAEEYQKSK-GADVSVKKMVIENMEFEREHYDKKSDSLEERGKQINEYKTLINNQLNQ 393 Legionella israelensis
WP_028387515 316 N-TRFEDLSLTAREE--ARQNFDARE-PEFRSIKRAVAQQVETSKLDLQRQEKVCQMRVNRLSEDYQSLLNQRQS 386 Legionella geestiana
WP_058520369 383 DiSPERQLSEQDWLQ--AKLNYEESK-PNICTANFFCNDQMKHELESLRERTQSCQSRAQELMNRIDKVQTTKLQ 454 Legionella tucsonensis
WP_028374115 281 G----EKLSDENRTT--AKQDFDNAK-GEMSSVKNLVSSNRSIEMGELDQKVKNLSDRITQLQTEKSQEDKRTTQ 348 Legionella lansingensis
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