4JW1


Conserved Protein Domain Family
LepB_N

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pfam18640: LepB_N (This model is not part of the current CDD release)
LepB N-terminal domain
Rab GTPases constitute the largest family of small GTP-binding proteins that act as molecular switches in regulating vesicular transport in eukaryotic cells. LepB is a Rab GTPase-activating protein (GAP) effector found in Legionella pneumophila. This entry represents the N-terminal domain which is followed by a GAP domain.
Statistics
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PSSM-Id: 523386
Aligned: 20 rows
Threshold Bit Score: 164.769
Created: 19-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4JW1_A        133 YYAGITKQNKYFGLSXALXFSLLLGAHSVHSGNIVVLNg---EEKE-KSKQFGRIDWGDAFRYFAHPNNNDNLLYAYENR 208  Legionella pn...
WP_131780744  128 DYGKLRAEGAWFALDESLMLSVIFGDNSVHSGNVVRLT----EVTPdRPRQFARIDWGAAFRNYGHPKNNRNVLVTLEIQ 203  Legionella is...
1_pfamImport    1 YTNAISSLDSYFGLSLIVFISLLFSDYSIHGGNIGLLT-------GpYQNQFCRFDFGASFRHFFKN---EKISNPHEYT 70  
Q9ZD12        142 TLEKAFKEIKYQNFEKIMPASLLIGDFDIHLGNIGVIRn---KKNPkTLPRLVRIDFAGSFDNLT-----DNIYPHSRIR 213  Rickettsia pr...
WP_028372347  131 YYPMLTKDGQYYGLSFALFFSIVLSAFSVHSGNIVRLHsqksDSSQtTANQFARIDWGDAFRHFASPDNNKDILSPAEYE 210  Legionella la...
WP_052403075  125 HYPTLTQQGRYYGLSMALMFSLLLGDYSVHSGNVVVLNk--fFDADtLIKQFARIDWGAAFRYFAQKENNEDILVPYEYQ 202  Legionella ma...
WP_058470631  125 YYLLLTNLEHYFGLSMVLMFSLLIADYSVHSGNVICLE------LKnHLIQFGRIDFGAAFRNFGYQKNNENVLYPLEYQ 198  Legionella jo...
WP_051546035  125 HYLLLTKLENYFGLSMVLMFSLLIGDYSVHSGNVVHLE------PQeGAIQFARIDLGAAFRNFGYPENNENLFHPKEYQ 198  Legionella la...
KTD65528      129 YYRAIADMQPYLGLALILMLSLLLGDYSVHSGNVVCFKy--lSLQEcFVTLLARIDLGAAFRNYACPDNNKDLLYPMEYQ 206 
WP_052679394  127 LYPNLTKQKLYFGLSVVLMLAILVGNFSVHSGNIVVFKnsrqSEDApEIKQFGGIDNGAANRDFARPENNEDILVPYEYK 206  Legionella mi...
4JW1_A        209 gw--fNYKSLTKDYFLNYKKINGLFPAXAEKARQLQSKLNP----------ELLVKIVTSALKNIPADLI--DEKTKIQL 274  Legionella pn...
WP_131780744  204 -----SLTAKHKNYYAKYQSIPGLFPSIALNAKTLQDKIGQkaeeseippeKLMTDIVSTALSQVPSELL--NGQTQKDI 276  Legionella is...
1_pfamImport   71 gl--aVYKKFTKNYLSYYQNIPGFYETVAEKAEDFLSNINQ----------PELKDIVSQAFNSIPKSVF--LQKDMEEI 136 
Q9ZD12        214 hlpgfGPTNHFREFPSSLRTKNPDFADSLLAASKID-----------------LSKIIDKSVDKLTKYY---SNEAIAKF 273  Rickettsia pr...
WP_028372347  211 gl--lNIKKWTKGYIDNYRNIRGLPTAIAAKGRVVLEAMGEkp-------eDVMLEIVQIALGKIPVDLV--DQETKTEL 279  Legionella la...
WP_052403075  203 gw--lNLKWLTKGYFANYKNIYGLFSAIATKASDLVGAMSE----------VPMKDIVNSALSQIPADML--DKATQVEL 268  Legionella ma...
WP_058470631  199 gl--fNFTAYTKGYLGNYKKITGLFSAIAGKAQMLAAEIDE----------PLLCEMVTAVLSRMPGDLI--DEITKKSL 264  Legionella jo...
WP_051546035  199 gl--fNIAGFTKGYFSNYRKITGLFSAIAGKAKALIPVVDD----------ELLKEIVSTVLKKMPANLI--DDRTREDL 264  Legionella la...
KTD65528      207 gm--aNYRWYTKGYIWNYLGIPGILPAIAAESASLKKRVSD----------EELADILTCVLNRIPADLL--DKRAKYEL 272 
WP_052679394  207 kgglrNHAWFTKGYIANYRNIKGLLPHIASHARELSERIG-----------GDFTEIITKVFKELPPDLLqnNQEVLAEL 275  Legionella mi...
4JW1_A        275 AAYXCXDSFKEATFgtEGNCKDFAIAXATLLENRLGKIAV 314  Legionella pneumophila
WP_131780744  277 AEYLGIPSFTEIDIknKDSYQHFAFDFTSVLMKRLQKTTQ 316  Legionella israelensis
1_pfamImport  137 SKYMGLDTYDKDIFveKISHHILKR--AKDIKDELATQEK 174 
Q9ZD12        274 AQRAMPKQFNKKSHa--ITTEEIKASLIDIMKKRQVSLQE 311  Rickettsia prowazekii str. Madrid E
WP_028372347  280 ADYLGIDAFRDVTFgkDGNYADVAKIFAQHLLNRINMTTI 319  Legionella lansingensis
WP_052403075  269 AKYMAIDSFADASFgpEGDYQQVADIFSSVLNDRLAKITV 308  Legionella massiliensis
WP_058470631  265 TSYLGIPSFMDLSLgnVTQKEPFCHDFAKILTLRLKKIIE 304  Legionella jordanis
WP_051546035  265 SVYLGIPSFCKVGLgsNLNHEPFCTDFVNVLTLRLAKLAK 304  Legionella lansingensis
KTD65528      273 AGYMGMGSFASVDFghVPSYQWFIKDMITTLNIRLTKMTE 312 
WP_052679394  276 AEYTAIPGFRTATFgpEGNCQSVIGKYAETLNLRLDKLGK 315  Legionella micdadei
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