4ZY8


Conserved Protein Domain Family
Longin_2

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pfam18639: Longin_2 (This model is not part of the current CDD release)
Yeast longin domain
This is a longin domain which is found in the N-terminal region of Lst4 proteins in yeast. Lst4 is the Fnip1/2 orthologue found in mammals. Lst4 forms a complex with Lst7 and are targeted to the vacuole when the cells are starved of carbon, and to a lesser extent nitrogen. Lst4 and Fnip1/2 belong to the DENN family of proteins which comprise an N-terminal longin domain, commonly found in a variety of trafficking proteins, and a C-terminal DENN domain. This domain is made up of a core five-strand beta-sheet, with one short alpha-helix.
Statistics
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PSSM-Id: 523385
Aligned: 23 rows
Threshold Bit Score: 120.056
Created: 19-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4ZY8_C         10 GFRLIISQELGHVTSRNNYQVVLDhss----------vnFHTGAHIP------------LN--------ELKDYIFGSSI 59   Kluyveromyces...
XP_018984646   79 LFRLVVCQDMGGLRKK---QVMCDsaat-------parkEESHPLTRplcsvrqspsppLTskihhpvrELMDYMFGCGL 148 
XP_011275655   66 KFRLFIIQDKGELMVKNNFKIYYDsnit-------ttnnGTTTNKNK------------IDyn----ifQFLEIMFGNSI 122 
XP_019041987   54 SFRLVIIQDKGELLMKNNYKTHYDsald-------phfnRPIHNKLS------------NKhe----ssELVEIMFGNPI 110 
SCW03162       51 QFRVVIAQEMGQIMSRHNYQIVLDyva----------srGSAMDQIS------------LS--------ELKDYIFGSPV 100 
SCU87478       52 RFRIVVAQELGQLMSRHNYQIVLDyvt----------arGSAMDHIS------------VT--------ELKEYIFGSPV 101 
XP_002554405   52 RFRVVVAQELGQMMSRHNYQVVLDyat----------srGSGMNHIS------------VS--------DLKEYIFGSPV 101 
SCV01670       51 QFRVLVAQDLGELMSRHSFQVALDycn----------arGSAMDQIS------------AN--------ELRNYIFGSAV 100 
XP_003648218   76 TFRLVVAQELGQMMSRDNYQVVLDcscsrnatmgplscsNGNVGQIP------------LS--------ELKEYIFGSPV 135 
Q757Y7         71 TFRLVVAQELGQMMSRDNYQVVLDcggt-------raavGSGGAEMP------------LS--------ELKEYIFGSPV 123  Eremothecium ...
4ZY8_C         60 RTID-YSaSSDKIKVVKS-------A----NIVLFTRIFYLNEKS-----------TlRIAISCCVT----DDVLPVLTE 112  Kluyveromyces...
XP_018984646  149 PIHE-NS-DVTKFHVFPRaslhrdaSppshVCVLITRIFTLAGTNtavedflerqrI-RVSIGLVVPldafADINKTLAI 225 
XP_011275655  123 HHDFqSN-ETIKIHNLESl-----------QFTLISKHFNIKLSNqk-------knL-KFAIGLIIPcs-iDLISTTITP 181 
XP_019041987  111 HHDLnRS-DNFKIHVMSSlp---dlK----NSILVSMHFYFDKKH-------------KFAIGIVIPig-lNDISSVVLS 168 
SCW03162      101 RAKN-RN-QSDKFRVVTS-------A----GVLLVIRAFYVSGGD-----------N-RHAICLCLP----DTFMTALSE 151 
SCU87478      102 RAKT-RL-KSNKFRVVSN-------A----GVLLVTRIFYAPNCD-----------T-RLAICLSLP----EPFLTSLSE 152 
XP_002554405  102 RAKT-RH-KCDKFRVVAG-------A----GVVLVTRVFYPSQRD-----------T-RLAICLSLP----ESFLSALSE 152 
SCV01670      101 RTID-PH-QSDKFRVLSD-------M----GVLLVMRVFPATGNG-----------Q-RLAMCLCLP----ESYATALSE 151 
XP_003648218  136 RISD-RC-QSDKIKLIKS-------A----RLIVVTRIFYNIHIPsti-----gppQ-RIAISCCIP----ECFFTVLTE 192 
Q757Y7        124 RLSD-RC-RSDKLKLSRG-------A----RVIVVTRIFYTGYAGn---------aR-RLAVCCCIP----EQFLTVVTE 176  Eremothecium ...
4ZY8_C        113 CWPHISSFLDQCENTL---LKYLAKNDTQFLPHDWK--ARNCIEVAAV-L--------QTFQRKIIPLL 167  Kluyveromyces lactis
XP_018984646  226 NWEEIVASMDDLQSCVsakLIAVLLA----NPTDLAapLSSPSTVNRLqFplyslqydQDINFQFAKFV 290 
XP_011275655  182 NWQTIIHYLSIFQSIFi---------KNHLLNYN-----------NYLdI--------SIFYKNFIKNL 222 
XP_019041987  169 NWVAVSNHLNLLKAIFi---------ENHLNIKKCNntSTQMASSNYLdI--------SIFFKTFIKST 220 
SCW03162      152 VWSHISKWLDECQALL---ESSLLRSGSSFLPRDLR--LQDPQSADSI-V--------QSIFKLLLPLI 206 
SCU87478      153 IWSQISGWLDECQALL---LAVLSNEQLPFLPRDLR--SHDPQITQSI-V--------HSIYTLVLPLV 207 
XP_002554405  153 IWTHIGRWLDECQALL---LAILSNDSLVSLPRDLR--AHDPQITESI-I--------QSIHTLIVPLV 207 
SCV01670      152 VWSYVTRWLDECRELA---TTIVASESVKPLPRNIG--VQASQSSEAI-I--------SSVYKLLVPVI 206 
XP_003648218  193 CWSQVSKWFDDCQKLL---APLLEAD--ILLPKELK--VSSPTHAESI-F--------HKFYRNLIIPL 245 
Q757Y7        177 CWSQVSAWFDEVQDVL---MPLLEAE--PLLPKDLR--VSAPAQVDVL-L--------HKFYRHLILPL 229  Eremothecium gossypii AT...
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