Conserved Protein Domain Family
IL3Ra_N
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pfam18611: IL3Ra_N (This model is not part of the current CDD release)
IL-3 receptor alpha chain N-terminal domain
Interleukin-3 (IL-3) is an activated T cell product that bridges innate and adaptive immunity and contributes to several immunopathologies. Structure of IL-3 receptor alpha chain (IL3Ra) in complex with the anti-leukemia antibody CSL362 reveals that the N-terminal domain (NTD), a domain also present in the granulocyte-macrophage colony-stimulating factor (GM-CSF), contains the CSL362 binding epitope. Furthermore, NTD of IL3Ra adopts a typical fibronectin type III (FnIII) fold.
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Statistics
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PSSM-Id: 523371
Aligned: 15 rows
Threshold Bit Score: 80.1579
Created: 19-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
KYO41147      54 ITNLTVNLKKLELTWDSSLNFTKYQCTL-KTKNSSVE--KKENKKNCIfSR---KPIHEGAIFRVEGN------YDMVSY 121
2_pfamImport   1 IINVDLDPRKKMLRWNCRGNVTEERCEIkTPLESFLIpsAQVQEDGTHyCMfpnAVLHQGALLSVAVTsdgdtfQEVLTF 80 
7_pfamImport   1 IVNLTLDPRKRILSWNSRRIVTQQTCTIaTPLDPDTSqePQVRNNDTYfCWfpnAVLHRGATLTVNATsegqefSEELAF 80 
8_pfamImport   1 IKNLRIDPERKRLVWDQHGNVSEIGCYVnSKI-------LRKATKNPY-CTlgdLS-CEVKNYTVKVMkgq-pfSDWILY 70 
5_pfamImport   1 IKNLRVDPESERLTWDLNGNVSKIECIKdSIQ-------HIEAMRNMY-CHidgLSLCTVSNYTVRASep--pfSTWILF 70 
XP_008246682  46 ITNLRMEAKPDRLTWDLHGNATNIKCIKdSKQ-------ILKAEQDRY-CEyhaLSLCKVSNYTVRVGnp--pfSTWILF 115
KFO22756     269 IGSLRVEPDSRKLTWDVLGNLSGIECSKgASI-------FRMAYENKL-CHfetMSLCTVTNYTVRVTqp--pfSSWILF 338
EHA98300       2 IGNLRVEPGSRRLTWDLLGNASGIECFKdGS--------TCLMAYDKY-CHystMSLCTVTNYTVKVTqp--afSAWILF 70 
ELV12577     308 IRNLRVEPGTRKVTWDRHADVTGVQCRRnGRD-------TKSATNNNY-CVyntLSLCNTANYTVSAAsp--pfSTWVLF 377
6_pfamImport   1 SLNVKFDPRNMTLAWDCQENTTSSKCLLvAKEEERVV--KKVRKEECW-CRfadLSLHQGALLEVQVVtsersmQEKLLY 77 

KYO41147     122 S 122
2_pfamImport  81 N 81 
7_pfamImport  81 N 81 
8_pfamImport  71 P 71 
5_pfamImport  71 P 71 
XP_008246682 116 P 116
KFO22756     339 P 339
EHA98300      71 P 71 
ELV12577     378 P 378
6_pfamImport  78 T 78
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