Conserved Protein Domain Family
LAL_C2

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pfam18603: LAL_C2 (This model is not part of the current CDD release)
L-amino acid ligase C-terminal domain 2
l-amino-acid ligases (LALs; EC 6.3.2.28) were discovered to be ATP-grasp superfamily enzymes that catalyze the formation of an alpha-peptide bond between two l-amino acids in an ATP-dependent manner. The members of this family share a common structural architecture that consists of three domains referred to as the A-domain, B-domain and C-domain. The C domain can be further divided into the C1-subdomain and the C2-subdomain. This entry represents the C2 subdomain.
Statistics
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PSSM-Id: 523367
Aligned: 159 rows
Threshold Bit Score: 46.4247
Created: 19-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
WP_014134928 338 AFLAPDrPGTVTAVHGLEAAGAAEGVRLAVVGIVPGHRAAGLRSSWDRVGIVTTLADTPAEARRLADAAAALVRFDID 415 Kitasatospora
WP_053428488 332 QFIVPGtSGVITEINPIKD-QHVKGIKETRLTVQIGDEVEAARNAYGRIGYMIAVGEDANDVLSVLQEASKQVKIEEK 408 Rossellomorea mar...
WP_003389355 332 RFLIPQeTGEIEEVTGIEQLQQMPGVKEVVCRAEPGKLVDRIVNAYGRLGYIIAVEADA----SKLHQLLNLIEKVEL 405 Brevibacillus
WP_034635023 331 RFIVPTnEGEITNVLGFEQIKDMLGIKEVKCRTVIGETVQKAQNAYGRVGHVIATSENSVELQSLLEKCINSLNIEVK 408 Bacillus manlipon...
WP_006288337 315 RFLISDtVGQVTHITGMDQAVQMHNVKDVKVNVLPGCHVSPPQNAYQRLGYVIAHGGTCEETVQSLDHAVQQIQIIAK 392 Paenibacillus pop...
WP_003389548 166 GFLLSGkEGTLQKVEGVEEVRSMPGIRNVTISARAGDRVYIPQNAYHRLGYVIASGGTYAQTEYRLKEAVDNIVFTVK 243 Brevibacillus bor...
WP_015893420 334 HFLVSEsQGTFGGIKGMDTVRNLPGIAEVAIHAKIGQNVQPPQNFSHRLGYVIVEGKHYSETAELIEQVKDSLSVQVG 411 Brevibacillus brevis
WP_015799119 321 WMLPTPhDGTFEGLDGVEVAAAIPGVERIEMTTTAGTTVYAPPRTRSYLGFVFVSGRSRRRVLSTLDQVRSVLRPRVA 398 Acidimicrobium fe...
WP_012875107 337 MMIPIPrSGILNKVSGMEEALSIEGIENIDINIPLKSHVTPLPEGATYLGFIFAKGPTPEKVEYSLRKAHSLLKIEIT 414 Thermobaculum ter...
WP_110171466 338 LMVPVPeTGRLRSVEGVDAVREMPSVTGVEITAKSGSMLETLPEGGTYPGFVFAEGAQPGDVIDALREASRRLRLVMD 415 Luteitalea pratensis
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