Conserved Protein Domain Family
EZH2_N

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pfam18601: EZH2_N 
EZH2 N-terminal domain
Polycomb repressive complex 2 (PRC2) carries out the methylation of lysine 27 of histone H3, a hallmark of repressive chromatin. Three core subunits make up the catalytic core of PRC2; the SET domain containing EZH2, the zinc-finger containing SUZ12 and the WD40 repeat protein EED. The complex forms a compact arrangement of three lobes. This is the N-terminal domain of EZH2.
Statistics
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PSSM-Id: 436611
Aligned: 18 rows
Threshold Bit Score: 127.392
Created: 19-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q2HFG6        227 GVKFKQHs-gEYGKSRGSGRRA--VVPVLCIKPDKEPVPGYRFHHVEIRKNILAPNSMLNFVPHLRDVDPNseEEQKYSN 303  Chaetomium gl...
KKY36209        2 KVHLKTHgsrDTARANSGRKKM--AYEVVCIKSDKPRVPEYKFHHVEISRNILTPNTMLKFIPHLRDMKDN--EEERYTR 77  
GAP88791      186 AMRIKTK---QVGQGRSGKQEKreKYPVVCIKTNLEPTPRYSFHHVEIKKNILSPNTMLTYVPHLRDLADN--EEGVYRR 260 
ERS99951      129 LLRGKLH---RDNQRRPEARTI--HARVVPLKTPGKAVPKYRFHHVEISKNILSPNTPLKFIPHLRDFEDNseEKRRHDQ 203 
4_pfamImport    1 TVRWKLH---RDNQRRPEGRVS--YVKAMSLKSPGQRVPRYRFHHVEIAKNILSPNTPLKFIPHIRDLEDGseDKYKYDQ 75  
XP_014168509  521 KVRIKLY---RDNQRRPEGRAM--NVRTISLKTPNTKVPKYRFHHVEIAKNILSPNTPLKFIPHFRDLEDGseDKKKFDQ 595 
XP_003347494  530 AFKLKLHh-gDNGKPRAPTKAF--ECPVVKIRTDKEAVPKYRFHHTEIKKNILVPNAMLTFVPHLRDVDPDslAEKQYIN 606 
CDP23036       76 TMTLKFK---QGKAIRAHGKHI--DFPVVCIASDRQSVPRYRFHHVEIRKNILAPNSMLNFVPHLRDVDPNsaEEKRYAE 150 
1_pfamImport    1 KVKLKQHg-rEHGKGKVDNRLC--RYRVICIKTDKQAVPPYRFHHVDIQKNILTPNAMLKFIPHLRDMEAS--EEKIFQL 75  
XP_003718975  255 KIKIKQHggrDGPQKQRNSELR--RYRAVCIKSDKKAVPSYRFHHVQIGKNILSPNAGLKFTPHLRDMGAA--EERTFNM 330 
Q2HFG6        304 WLRDLE 309  Chaetomium globosum CBS 148.51
KKY36209       78 WIKELE 83  
GAP88791      261 WLENLE 266 
ERS99951      204 WIEELE 209 
4_pfamImport   76 WIEELE 81  
XP_014168509  596 WIEELE 601 
XP_003347494  607 WLNELN 612 
CDP23036      151 WLNELE 156 
1_pfamImport   76 WVHELQ 81  
XP_003718975  331 WISELK 336 
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