Conserved Protein Domain Family
CdiI_2
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pfam18593: CdiI_2 
CdiI immunity protein
Contact-dependent growth inhibition (CDI) is an important mechanism of inter-bacterial competition found in many Gram-negative pathogens. CDI+ cells express cell-surface CdiA proteins that bind neighboring bacteria and deliver C-terminal toxin domains (CdiA-CT) to inhibit target-cell growth. CDI+ bacteria also produce CdiI immunity proteins, which specifically neutralize cognate CdiA-CT toxins to prevent self-inhibition. Structure analysis of CdiI immunity protein from Yersinia kristensenii shows that it is composed of eight alpha-helices packed together to form a nearly spherical structure with weak structural homology to a putative TetR family transcriptional repressor. The CdiI protein fits into the curved cavity of the CdiA-CTYkris toxin domain where it most likely neutralizes toxin activity by blocking access to RNA substrates. This domain is mostly found in gammaproteobacteria.
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Statistics
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PSSM-Id: 497370
Aligned: 25 rows
Threshold Bit Score: 79.2649
Created: 19-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
WP_057293013   7 SFPYLEQLLGGWFHQDFDLAGGt---IEAIMENYRSTaHPHDVMGVKADIQRFIHNAEANKadLEKAFvKQF-NPDILPA 82  Noviherbaspiril...
WP_056152936   8 EWPALWHLMGAYLHQDFDAFGT----IDENIDLFVVDs-PDLAPALPSEIDRALRALPTEA--ALEAFvDDL-GCQVRAP 79  unclassified No...
WP_011757163   2 ETRALRHFMGAYLHQDFDLVGS----VEDNLALFVRQs-PALAAALSDEVADLLAHPFTDGe-LERLL-DEM-GCEASPP 73  unclassified No...
WP_029991162   3 NFHFLDQLIFGYFNQDADIINDgedtIEGIVRLFKKSaPDWMLKDLVEEVDDFISAYGDG---VEEEFrKRY-GFDFSPE 78  Erwiniaceae
Q7N7X3         4 QYPFLDILMHAYFNQDFDIISGp--eLDDVINDFLNDaSQGMRKGLIEEINDLIDSSE-D---VESTFdYHYhDADVLPE 77  Photorhabdus la...
WP_025374133   3 HYPHIRNLLDAYLNMDVDTIAGtd-ePDEIIQYYVLDtSKPVLEELVDELDHFEESNGQN---LDDMF-----EKEFSPE 73  Advenella mimig...
3_pfamImport   1 RYPELSNFIKNYFGEDFDLWGNt---IEEIFALYKSEnDISARSQLGRDIDAFRCDNS-SD--LDASFkALY-GLFFNPV 73 
WP_042390265   7 KTCELDNLVTIYFGQDCDIFDEnc-dFDNLLNEYLSTsSAFSLRMLLANLIELNAQDD-----RCEVLlARY-NGEFAPE 79  Enterobacteriaceae
1_pfamImport   1 KAIHLGTLVRVFFGQDYDLFGEg---IDEILASYRNTeNQQTIQKTIDEANMLLTAYPEEKe-LELEFtDLA-EGEFSPA 75 
WP_021006048   3 RYELIENLTEVYFGQDYDYFGEt---GAEIMAEYRKAcTPAELEALRVEIVDFMRSHPD----LETDFpRRF-ERPAQPE 74  Variovorax

WP_057293013  83 AWGMSTKNWLLYLNELL 99  Noviherbaspirillum sp. Root189
WP_056152936  80 -DNLTYREWLTRIADRV 95  unclassified Nocardioides
WP_011757163  74 -VGKTYRDWLTQIADRV 89  unclassified Nocardioides
WP_029991162  79 LWETTAHEFLMTVRQIS 95  Erwiniaceae
Q7N7X3        78 GWGMTALEFLTHVSNKS 94  Photorhabdus laumondii subsp. laumondii
WP_025374133  74 VDIADIREFFNDLRTAI 90  Advenella mimigardefordensis
3_pfamImport  74 SWNHTTASFLDELKRLL 90 
WP_042390265  80 RWDMSAQDWLDIVNSRL 96  Enterobacteriaceae
1_pfamImport  76 SWGYNVQSFLEKIVITL 92 
WP_021006048  75 DFGSTIREFLESVLAAL 91  Variovorax
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