5FOR


Conserved Protein Domain Family
TIR_3
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pfam18567: TIR_3 (This model is not part of the current CDD release)
Toll/interleukin-1 receptor domain
This is a Toll/interleukin-1 receptor (TIR) domain found in the N-terminal region of B-cell adaptor for phosphoinositide 3-kinase (BCAP). BCAP functions in linking the B-cell receptor (BCR) and the co-receptor CD19 to the activation of PI3K via interaction with the SH2 domains on the regulatory p85 subunit. BCAP TIR associates with the MAL/TIRAP adaptor and the TIR domains of Toll-like receptors (TLRs).
Links
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Statistics
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PSSM-Id: 523342
Aligned: 24 rows
Threshold Bit Score: 137.734
Created: 19-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
5FOR_A          8 DILIVYSPDAEEWCQYLQTLFLSSrqVRSQXILTHRLGpEASFSAEDLSLFLSTRCVVVLLSAELVQHFhXPSLLPLLQR 87  human
10_pfamImport   1 DILIIYSPDAEEWCQYLQDLFLTSrqVRSRKMLTHRLGpQTSFSAEDLHLFLSPRCVLVLLSAELVQHFyQPALLPVLQR 80 
5_pfamImport    1 DILTVYSPDAEEWCQYLQDLFQASrqVRTQKLLTHRLGpDASFSAEDLLLFLGARCVVVLLSAELVEHFyRPALLPLLQR 80 
KYO48175       77 DVLIAYTDDAAEWCQYLQNLFISSrqVRKQRILSYKVEsGTAIPHEELDLFRSSRCILVLLSGELVQNFyVPAALQSLQE 156
8_pfamImport    1 DVLIVYGNDADEWCHYLQSLFHSC-----YEVQSYQMEcGTVISMEKLDLFKHSKCIVILLSSDLVQNFyIPAVLQSLQN 75 
KFP08578        8 DVLIVHGSDAREWCQYLQNLFLFTrhLRKHRILGYQLEgEVALSPQELDLFHRSRSIILLLSAELVQSFyLPPVLQSLQE 87 
12_pfamImport   1 EVLIVHTDEAEEWAKYLQNVFISSrkFSKKSVFLKQVEkNTPLGQSEMDDFHKSKCILLLLSMQFLENLyIPIVLETFLK 80 
XP_009305657    3 EVLIVHSGEAREWADYLQQILAAScsFQEGSVVLYDVDeEICLK--NYGPFGSSKCILLLLTSGLVNLQnDSVVLDTFRD 80 
XP_040033701   21 ELLVLHAAEAQEWAAYLQQILKSSkkFRKKSILLYAVDlDDQLHGRDFESLQSCECVVLLLSAAILSMLcDPEVQGALLG 100
XP_064419154   11 GVLVVHSNDALEWSQYLWNLFSSSkqFKHDRIMCYKIQdDTSIEGQDLDIFKESRCILLVLSGELVKTLsTSWVLESLQK 90  coelacanth

5FOR_A         88 AFHPPHRVVRLLCGVRDS-EEFLDFFPDWAHWQELTCDDEPETYVAAVKXAI 138 human
10_pfamImport  81 AFQPPRRVVRLLCGVQGSeEEFSHFFPNWTHWQELTCDDEPEIYLEAMRKAI 132
5_pfamImport   81 ALYPPHRVVRLLCGVQGAqDEFLPLFPDWADWQELTCEDEPEAYVAAVRKAI 132
KYO48175      157 ALHPPHKVVKLFCGVTDC-DDYLTFFKEWYQWKELTYDDEPEAYLEAIKKAI 207
8_pfamImport   76 VLQPPHKVVKLFCGVSEC-ETYKEFFKDWPQWKHLTYDDDSDAYIAAVMKTI 126
KFP08578       88 ALWPPYKVVKLFCGVTDS-EDYSTFFKDWSQWQELTNDDEPDAYLAAVKKAI 138
12_pfamImport  81 VLHPPSKMVLLFCGVTES-EGLEQFFSDWQKWKRLYPEDETTTYISTVLQTI 131
XP_009305657   81 LLHPPHKVVAFLCGVSEE--LMSGYFEYWEQWRKIFSEDEPQVYVSTIRESI 130
XP_040033701  101 LLQPPQRVVVLLCGVRED-DVPTEWLQDWPNFRKLYPDDEPALYISTVLQSI 151
XP_064419154   91 ALHPPHRVVVLLCGVTEH-DDFSDLFKNYQLWKKISCDDEPDVYISTIKQTI 141 coelacanth
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