Conserved Protein Domain Family
MobL

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pfam18555: MobL 
MobL relaxases
This family includes members of relaxase enzymes. These enzymes initiate bacterial conjugation contributing to the spread of antibiotic resistance. These MobL relaxases are found mainly in Firmicutes. It is suggested that MobL type relaxases play a prominent role in horizontal gene transfer in Firmicutes bacteria. Family members carry a stretch of relaxase motif III 'HUH' sequence that is characteristic of the HUH endonuclease superfamily essential for enzymatic activity.
Statistics
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PSSM-Id: 497336
Aligned: 7 rows
Threshold Bit Score: 387.598
Created: 19-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
WP_012655854   1 MAGIVVISNFVVGNNKKnYS------GII-DYYERYEEKntriqnEKEvlsefydyeqdggdetlfefinnTYDNPPNIN 73  Macrococcoides ...
WP_054679368   7 SPGIVSVTHFKQASNKK-FG------DYV-KYIDRDDAT------RVK-----------------------YFNKWNFVE 49  Lacticaseibacil...
KRN24164       6 SPGIVTVMKFVPAPDKK-FS------GYV-NYMDRPDAM------RGD-----------------------HFKEWNVNR 48 
WP_035507940   6 TPGVVLKTKFVTAKKKG-FQ------DYV-QYVDREEAK--------------------------------GKGETHRSM 45  Halobacillus ka...
1_pfamImport   1 TPAVVFHLDMIQPTSKKwVIak--gfDGM-SYMNRDGKFlp---kKEK-----------------------TFKSQATVN 51 
WP_006378626   4 KQDIIVVNEFSVPLPSGkGSrgatpgDYVtRYMAREQATeslapiQRLrtddfim----------rymareSAVERAGIS 73  Streptomyces tu...
EGJ47733       1 MAGLIVKSPYLKCGGGSsVS------GYL-RYIGTRERVeilpddRPPtrkqeq------------litklTKDFPEAKE 61 
WP_012655854  74 FGNYINYMNKN-------IKSSGL---FGD---------------------DTNHFTSDEKEVMKEAFNKGQENGSVLWG 122 Macrococcoides ...
WP_054679368  50 RDGYNEYMGNP-------EKSTGL---FAS---------------------FSDHLGKDERHKVALEFGKAQKAGSNMWQ 98  Lacticaseibacil...
KRN24164      49 FDGYNYYMNNP-------EKSKGL---FTA---------------------GKDSLTQEERTELKRQFALAQKNGSLMWQ 97 
WP_035507940  46 FSLYNHYMDDP-------DKTSAL---FTQ---------------------QSDRLTVEGKQGIKSLFEQAQKKNSIMWQ 94  Halobacillus ka...
1_pfamImport  52 KD-YIDYMNKN-----------GV---FDT---------------------NYSMLTEKQMDTYRDYERQSKSEGCPKYV 95 
WP_006378626  74 RGAAKHEMRQA-------QGDGGVa--FGY---------------------GSVSLSDEQLRAAGKDIQHYFDAGHTVLK 123 Streptomyces tu...
EGJ47733      62 LGEYSDYKDKPtkanasvFITRALeenWAQvqqsdgymkyiatrpraerlgDHGLFGDEDAVDLEQAMQELDQYNGNVWT 141
WP_012655854 123 NVYSFDNEFLKKHKLYDEETGF---------LNEIKI-KEAVRSSIRTMLKEEK--IDSSAV-WCGEIHYDTDNIHVHTS 189 Macrococcoides ...
WP_054679368  99 TVVSFDNPFLEKYGLYNSKTDV---------LDEEKI-RAATRIAMEEMLKREG--MSSSAL-WTAAIHRNTDNIHVHIA 165 Lacticaseibacil...
KRN24164      98 TVVSFDNRFLADHGLYNLQSKQ---------LDQEKI-QQTIRNGMSGLLINEG--LANTAV-WSASIHLNTDNIHVHIA 164
WP_035507940  95 DVITFDNKWLQNRGVYDSKTHT---------LDEDAL-KQVTRKSMQAMMKKEG--LQESAI-WSAAIHYNTDNIHIHVA 161 Halobacillus ka...
1_pfamImport  96 GYLSFDNQFLVDNGLMIGEV-----------LDRAKL-MDIARKGINSLIDKSNklKNENTY-WYAAIHEDTDNIHVHYT 162
WP_006378626 124 TVLSFDEEYLRKHKIVDEDFHCeargnyrghIDQMKL-RMAIMHGLERMSSGTS--GFDDLR-YVGVIQVDTEHVHCHLA 199 Streptomyces tu...
EGJ47733     142 HILSLKREDAARLG-----------------YDNAKAwRNLLRTNRNEIAAAMN--IQPNHFrWYAAFHDEGKHPHVHMM 202
WP_012655854 190 IVEMKNTRPIVMVEKMkklgskhyeptgefELQPKAKLKK-KTLDN--MKSVFA---NKLIDRSKDMKAISDL-RTSLHH 262 Macrococcoides ...
WP_054679368 166 TVEPVPSRPLQPFNDPdth---------ekYWARRGSFKP-STFSA--FKSKFA---NQILERDQELAKISTLiRDRMPP 230 Lacticaseibacil...
KRN24164     165 FVEPEPTRQSILIHDSeg----------qvKEAANGMIKR-STISA--FKSSIA---NELINRDQSLARLSILiRNEL-P 227
WP_035507940 162 TVEPNPTRD-------------------------RGKRKP-KTLDA--MKSEVV---NGLLDRTQERNQINALiREHMIN 210 Halobacillus ka...
1_pfamImport 163 LLEYHRLEDRTVTYKG----------------KGQDLLEQ-DAFKK--MKSTVA---NEIMTKKLTPE-LTAFkRKNLIP 219
WP_006378626 200 MVDGGRGQV-----------------------TKNGTQRG-KLLDR--HKSRLRrgvDAWLDEKQAVAHLASAvGYERRN 253 Streptomyces tu...
EGJ47733     203 AWSTQPGEA---------------------YLTRDGIRNIkSTLTNqiFKQEML---HTYEQKSQSRDELVREaRRAIRQ 258
WP_012655854 263 SIKlDDSKT----SQIKLLNTIRKNLPKEKSKWQYNNKE--MKNLRPLIDNYTMNYIKTNNK--KDYQVYTKLLKDEEDF 334 Macrococcoides ...
WP_054679368 231 DTK-LWRAApt-vQMNLLYQEIYKKLPRNKQLWRYNDNA--MKEFRPEIDRLTSIYMEKYKP--VELAEFRKAVAEEVEV 304 Lacticaseibacil...
KRN24164     228 QHDyDWGKLpn-fDLLRLYQQIYKALPDDKRKWKYNMNA--LQEARPLLDAFSSKFMQRYHA--NELQEFDQALKAETDF 302
WP_035507940 211 RKKeKSSMKwsnrELKPLFLEVYNHLPKDKRQWYYGYQT--LNPIRPKIDELTTMYLNKYHA--KDMKQLYDKLDQEVSE 286 Halobacillus ka...
1_pfamImport 220 E---FSSSIvaskEMIELLKLLPPKPPH--SAWQYDNVK--VRPYQRRIDMCVDKIISCNEKlqAEFDEYVEKLKMADEQ 292
WP_006378626 254 VTTfIKRWAheriRAESLPQFLLACLPADRTLWRAGSNDarMRKANQLVTELVKEQLDRAG---SPMPEAMERIVDYANE 330 Streptomyces tu...
EGJ47733     259 LTQeMTRSIctapEIEQKMEQLAGQLEIVRGKKSYGYLP---KSVKKTVDEVVDKLEEL-----PVVRECYDRWCWLQDE 330
WP_012655854 335 YKDLYGEGKd----NRYKDPSKNKLEDLKGRMGNALLKELKKEN---RSMTYKNYNGNINNEKT---------------- 391 Macrococcoides ...
WP_054679368 305 RRDVYGTGQegkelGRYEDYADNKFHELQARMGNSVLGDMRNFDaelKAKYHDKTPGKFDERLAeggsplhqtlgrmggl 384 Lacticaseibacil...
KRN24164     303 REALYGSGQegkeaGRAKDYEHGKYDELYARMGNSILSEMRKTD---DAVYRKEHPNGLSNHKAqrg------------- 366
WP_035507940 287 LKQAYGDGSkd--kKRYQHYRQNKLDDLYKRMGNAFLQEMKRYD-------HQQYPRQTTNTNApyks------------ 345 Halobacillus ka...
1_pfamImport 293 YKRFYGENS------DYFEYSNNQLDDFYNRAGNKLLQELAKLQy-rLDKNYVKESDFTDMEKAvskk------------ 353
WP_006378626 331 RRAKESLST-----EEWQKLVEQGRTQIMERAVNGVYQMLRAMP---ESELRVRTPMLEVMGMD---------------- 386 Streptomyces tu...
EGJ47733     331 VESYYHNNP--------RERKKLSQEKEFRQIKNAVIQEAERIRl--GEISFEDDGISQTDEPEhvrde----------- 389
WP_012655854 392 ------KVKNSRLVDRNKYIDGNLK 410 Macrococcoides caseolyticum
WP_054679368 385 krllatDMKNMRLAKQQHKRMEREA 409 Lacticaseibacillus sharpeae
KRN24164     367 ---qpnQGIFQALSSIRRALSGDMK 388
WP_035507940 346 --mpagIHLQRSLRSIQRSMGQTYD 368 Halobacillus karajensis
1_pfamImport 354 --eekmAYKEFKEHLSKNELLQAQS 376
WP_006378626 387 ---------YQQMAVLAADRQGEDQ 402 Streptomyces turgidiscabies
EGJ47733     390 --sqacRELWRIIGNEDISLDYRDR 412
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