6RW8,8CQ0,6RW9,6RWA


Conserved Protein Domain Family
TcA_RBD
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pfam18518: TcA_RBD (This model is not part of the current CDD release)
TcA receptor binding domain
Tc toxin complexes are virulence factors of many bacteria such as the plague pathogen Yersinia pestis. Tc toxins are composed of TcA, TcB and TcC subunits. TcA forms a large bell-shaped pentameric structure and enters the membrane like a syringe, forming a translocation channel through which the cytotoxic domain is probably transported into the cytoplasm. TcA has four receptor-binding domains. This domain is one of 4 receptor binding domains found in TcA. All four domains have an immunoglobulin (Ig)-like beta-sandwich fold of two sheets with antiparallel beta-strands. The domains are structurally reminiscent of the receptor-binding domains of the diphtheria and anthrax toxins.
Links
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Statistics
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PSSM-Id: 523319
Aligned: 13 rows
Threshold Bit Score: 143.302
Created: 19-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
6RW8_A       1637 EPQLGEGFYATFKLPPYNKEEHGDERWFKIHIGNI--DGNSArQPYYEGMLSDI-E-TTVTL---FVPYAK--------- 1700 Xenorhabdus n...
WP_034934011 1637 EPKLGKGFYVDFVLPPYDAKVHGNSPDFTLNLKHV--VDNNA-HVVYSGQLTES-E-YSVRL---FVPLDEk-------- 1700 Erwinia mallo...
WP_038240574 1667 EPQLGKGFYATFTLPPYNSATHGTNQAFQLNLKHV--VDDNV-HVIYAGLLQDT-E-LAVRL---FIPLDDt-------- 1730 Xenorhabdus s...
2_pfamImport    1 EPQLGKGFYATFTLPPYNSATHGTSRAFQLNLKHV--VDDKV-HAIRSGLLQNT-E-FAVRL---FIPLDDt-------- 64  
Q7N7Y1       1568 ELQLGKGFYATFVIPPYNPSTHGDERWFKLYIKHV--SDNNS-HIIYSGQLKDT-N-ISITL---FIPLDDi-------- 1631 Photorhabdus ...
Q7N7Y9       1637 EPVLWSDNF-TATLPIYNSSLHGNSKNIKIMLGNSekQPDQA-NVIYQGELTDK-N-QLINLsetYISIKErsnntkpvd 1712 Photorhabdus ...
WP_004236989 1596 EPKPGQGTYVTLTLKPYDKNTHGTNRAFTIYYSND--ATGSGkFPVYSGSLSVT-DnTEVKL---FIPLIKpgknavsqs 1669 Morganella
Q7N7Y6       1501 EPMMGIGAYIEIVMDKYNTDIHGTNKSFKIMYGDI--FKAGDhFPIYQGTLSDI-TqTTVKL---FLPRVDn-------- 1566 Photorhabdus ...
WP_038240555 1690 EPKMGQGTYVTLDLLKYTPAIHGDSMAFALYHDH-----GAGkDPIFRGMLSSR-TtTTVNL---FLPRIE--------- 1751 Xenorhabdus s...
Q7N7Y0       1331 EPQLKAGFFANFTLPKYDQNIHGNERWFKIHIGNI--NGDNSmRLYYQGTLTDN-E-TSITL---FVPYKK--------- 1394 Photorhabdus ...
8CQ0_A       1653 EPQLGKGFYATFVIPPYNLSTHGDERWFKLYIKHV--VDNNS-HIIYSGQLTDT-N-INITL---FIPLDDv-------- 1716 Photorhabdus ...
6RW9_A       1596 EPKPGQGTYVTLILKPYDKNTHGTNRAFTIYYSND--ATGSGkFPVYSGSLSVTdN-TEVKL---FIPLIKp-------- 1661 Morganella mo...
6RWA_A       1504 EPMMGIGAYIELILDKYNPDIHGTNKSFKIIYGDI--FKAGDhFPIYQGALSDI-TqTTVKL---FLPRVDn-------- 1569 Photorhabdus ...

6RW8_A       1701 GYY--------IREGVRLGVGYKKiIYDKSWESAFFYFdETKNQFIFINDADHDSGMtqqgivknikkYKGFihvV--VM 1770 Xenorhabdus n...
WP_034934011 1701 PLN--------VNYCAKVFLRTRT-AGDGSWKGPHFQY-TDNSQTAVRINPSSDISM-----------FNSV---T--IL 1754 Erwinia mallo...
WP_038240574 1731 PRS--------DEFIAKVFLITQKnKNDTAWAGPHF----TNKGGVIGIHKSSDVSM-----------FANIq--I--HN 1783 Xenorhabdus s...
2_pfamImport   65 PLH--------DEYIAKVFLTTQKnRNDVPNVGAHFKYdKSNNNRIVINDDISDISM-----------FAGIq--I--HN 121 
Q7N7Y1       1632 PLN--------QDFHAKVYMTFKQsPSDGSWSGPHFI---RDNKGIITINSSSILTH-----------FESVn--V--LN 1685 Photorhabdus ...
Q7N7Y9       1713 NKG--------NDSWIYLFVKYSTnPIKI----GEFWFkNGTNFQGYYPKGNEKNRDp-----------------I--FI 1761 Photorhabdus ...
WP_004236989 1670 AGA--------QQDTLYLNATYQKeATKQ-----ILLFrTDNNPEGWTLDKSVNNGT-----------FAGLaenG--VT 1723 Morganella
Q7N7Y6       1567 AYG--------NKNNLYVYAAYQKaETH------FIRFvKEDNNKPATFDTTYNNGT-----------FPGLasaR--VI 1619 Photorhabdus ...
WP_038240555 1752 SSG--------KSDDLYVFAKYASsDTVS----IRFIRkDPTNPDGWSLDAEYNKGT-----------FPGLk--S--VY 1804 Xenorhabdus s...
Q7N7Y0       1395 DLY--------TMEGVRIGVQYKQkFYQDWWEPAFFYFnETQQKFVLINDTAHDSAMthggerspvkkYQGFsnvS--VL 1464 Photorhabdus ...
8CQ0_A       1717 PLN--------QDYHAKVYMTFKKsPSDGTWWGPHFVRdD---KGIVTINPKSILTH-----------FESVn--V--LN 1770 Photorhabdus ...
6RW9_A       1662 GKNavsqsagaQQDTLYLNATYQKeATKQ-----ILLFrTDNNPEGWTLDKSVNNGT-----------FAGLaenG--VT 1723 Morganella mo...
6RWA_A       1570 AYG--------NKNNLYVYAAYQKvETN------FIRFvKEDNNKPATFDTTYKNGT-----------FPGLa--SarVI 1622 Photorhabdus ...

6RW8_A       1771 K--NNTEPMDFN 1780 Xenorhabdus nematophila
WP_034934011 1755 S--DTSEPMDFS 1764 Erwinia mallotivora
WP_038240574 1784 G--TTTEPLDFN 1793 Xenorhabdus szentirmaii
2_pfamImport  122 G--ETTEPLDFN 131 
Q7N7Y1       1686 N--VSSEPMDFN 1695 Photorhabdus laumondii subsp. laumondii
Q7N7Y9       1762 En-QKTEPMDFS 1772 Photorhabdus laumondii subsp. laumondii
WP_004236989 1724 GllQSGEPMDFS 1735 Morganella
Q7N7Y6       1620 Q--TFSEPMDFS 1629 Photorhabdus laumondii subsp. laumondii
WP_038240555 1805 GlsVPTEPMDFS 1816 Xenorhabdus szentirmaii
Q7N7Y0       1465 S--EHTEPMDFN 1474 Photorhabdus laumondii subsp. laumondii
8CQ0_A       1771 N--ISSEPMDFS 1780 Photorhabdus luminescens
6RW9_A       1724 GllQSGEPMDFS 1735 Morganella morganii subsp. morganii
6RWA_A       1623 Q--TVSEPMDFS 1632 Photorhabdus luminescens
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