Conserved Protein Domain Family
PIN_11
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pfam18479: PIN_11 
PIN like domain
This is a eukaryotic/eumetazoan PIN like domain found in the C-terminal region of bilateral ZNF451 proteins such as isoform 1 of human ZNF451. ZNF451 was shown to interact with p300 by the PIN-like domain and to negatively regulate TGF-beta signalling in a p300-dependent and sumoylation-independent manner. This domain is suggested to posses a potential active nuclease due to the presence of at least four conserved Asp residues in the predicted active site. Furthermore, it contains several conserved Cys and His residues, which may suggest stabilization of the domain structure with an embedded short zinc-binding loop.
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Statistics
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PSSM-Id: 436532
Aligned: 3 rows
Threshold Bit Score: 217.807
Created: 19-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_008515926  884 TMTHIVFVDFDNWSNFFGH-LPghLNQGTFIWGFQGGNTNWKPPLNCKIYNYLNRIGCFFLHPRCSKRKDAADFAICMHA 962 
XP_048581888   24 NMRHIVLVDIDNWKGIFKSdLP--FSQRTFVWGFWSGNTSWDPPKGSALFQELENHNCFYLHPKCSGSKDAADFALCAQA 101 
XP_014775616  652 QMKHIIFLDLDNWTGIFKH-VHhyFPNETFLWAFYGAKTKWFPPKS-DVYKKLVQDGCFFLNPKSGYTKQAADFALVLHV 729 

XP_008515926  963 GRLDEQLPKQIPFTILSGDQGFLELENQFKKTQRPAHIL 1001
XP_048581888  102 YKLDIMLPKSIPFTVLSGDCGFQELQNQLSRCNREIHLV 140 
XP_014775616  730 GKMDERLPVHIKFTILSGDKGFYEVSHQFENSKRHMQIV 768
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