Conserved Protein Domain Family
PH_18

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pfam18469: PH_18 
Pleckstrin homology domain
This is a Pleckstrin Homology (PH) domain found on the N-terminal region of the histone chaperone Rtt106 in yeast. Rtt106 binds histone H3 acetylated at lysine 56 (H3K56ac) and facilitates nucleosome assembly during several molecular processes and this N-PH domain is shown to mediate histone binding.
Statistics
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PSSM-Id: 497275
Aligned: 24 rows
Threshold Bit Score: 146.214
Created: 19-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q6BYP2        80 QIHEQEIIFELPQISFQSPIRKKLNLIFHLlvePGQSPKPVMSLAlpTTYVPEISIHNL-ASSIRLCVLLPIlgnstnNT 158 Debaryomyces ha...
XP_001385033  87 PIVEETIIFEIIQTSFISPIRKKMSLIFHLi-eRNGQPLPVLSIVhpTTRVPEISVIDL-TECVKLCAFIPIvgnssnPS 164
EMG45797      58 EILDQSVIFKIPQVSFMSPLRKKMDLTLHLs--VGEEPAPVLSIVnpATNIAEISFTDL-KEAIKLCVILPIignstnAS 134
A5E4Y7        74 TIHPDTIIFEIPQVSFMSPVRKRMNLTFHLi-eQNGQGLPVLSIVnpANNSPDISYINL-QNAVKLCLILPIlgnstnPL 151 Lodderomyces el...
XP_036663093  85 SIHPESIIFEIQQVSFSSPIRKRMNLTFHLi-eQNGQALPVLSIVnpTNNSPEISFINL-KHAIKLCLILPIlgnttnSK 162
Q59S27        54 EIPPETIIFEINEISFYSPVRKRMNLTLHLv-eEDGNPSPALSIVnpSNNIPELTFTGL-DQAVKLCLLLPIlgnttnTQ 131 Candida albican...
XP_006688779  77 KILEEETIFELPQISFQSPLRKKMNLLLHLl--PENGANPILSIVnpTTSEPELSYIQL-DKAIKLCVLLPIlgmstvES 153
CCE79417      79 GINEQEIIFELPQISFQSPVRKKLSLIFHLtlgSNGQPEPLLSIAspVTYVPEFTIRDL-SSSIRLCVLLPIlgnsttAS 157
XP_002492754  51 NFADYTVILQLPSLSVQSPFRSKSNLIFACp--KSDTSKPILAIAk-TNEKPQLILDKLnDENVLYAVILPI------PE 121
XP_013937309  53 SLAGSHIVLQIPELSVQSPIRKKLNIVFGC---FSGERKVFLALTksLESKPELLITDLsANNIQFAVVLDV------PE 123
Q6BYP2       159 KRNIGLLCFWIhdDA-ASDPNKNDPIICQVNFDQVKKQLIKAGKIPAEAEtQLkemnesnqsqdgikainEAIINFLQKQ 237 Debaryomyces ha...
XP_001385033 165 KKSIALLCFWIkdEY-IGSSAVKDPIVLQVNLDMVKKQMISQGKLPPDIEhQFekesptn---vnmnpiqERIIDYFQRQ 240
EMG45797     135 KRGVCYFCFWIrdEYyPSESGSKDPVICQLNLDLIKKQLIKDEHIPANIEsQYihakdsl----vlhpvqENIVDFFKRQ 210
A5E4Y7       152 KKGVVTLCCWMhdLYyTDVNVSKDPLILQLNLDAIKKLMIKSEKLPADIEnQFdltnyrns--vilnpiqERIIDYFTRQ 229 Lodderomyces el...
XP_036663093 163 KKGVALLCFWIhdQYyTDSNVSKDPIICQLNLDMIKKQMIKNGKLPPDIEsQFdlsthknd--valnpiqERIIDYFKRQ 240
Q59S27       132 KKAICYLCFWM-----HDENMSKDPIVCQMNLDLVKKSMIKNGKLPADIEsKFitprdal----plnpiqERIIDYFKRQ 202 Candida albican...
XP_006688779 154 KKNIGSLCFWLsdEA-IPDPTKTDPIVCQINLDLVKKHLVKTGKIPATAEsQMleptqle----gikpinEAIIQFLTRQ 228
CCE79417     158 KKNIGLLCFWIkdSA-VENVPKNDPIICQVNFDTAKKQLIKTGKIPAEAEtKInalnaknensdgikpisEAIISFLQRQ 236
XP_002492754 122 KKDFKNLAIFYk-EN-MGGVHKNEPLLIQYNESLISESLKL--ILQKM---TF-----------------P---TYFQRQ 174
XP_013937309 124 KKQYKTLLITYd-SN-KGQMYKNDPILIQFNNDELSEQFGP--LLDKI---DL-----------------T---DFLQQQ 176
Q6BYP2       238 FQLCGIHMINY 248 Debaryomyces hansenii CBS767
XP_001385033 241 FKLCGVNLMNY 251
EMG45797     211 FELCGINIVNY 221
A5E4Y7       230 FKLCGVNLVSY 240 Lodderomyces elongisporus NRRL YB-4239
XP_036663093 241 FQLIGINLVNY 251
Q59S27       203 FQLCGISMMNY 213 Candida albicans SC5314
XP_006688779 229 FKLCGINLINY 239
CCE79417     237 FQLCGIHLINY 247
XP_002492754 175 CSMLGFKL-NL 184
XP_013937309 177 FRTFGFDLVKG 187
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