2MJM


Conserved Protein Domain Family
Atypical_Card
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pfam18461: Atypical_Card (This model is not part of the current CDD release)
Atypical caspase recruitment domain
The N-terminal effector domain found in NLRC5. It adopts a six alpha-helix bundle with a general death fold. Structure and sequence analysis of the NLRC5-N indicate that it possesses a fold similar to the one of the death-fold domains; however, it displays significant differences in the number of core alpha-helices and their relative orientation. Hence, it is suggested that NLRC5 belongs to the caspase recruitment domain (CARD) subfamily as an atypical CARD.
Links
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Statistics
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PSSM-Id: 523295
Aligned: 15 rows
Threshold Bit Score: 144.442
Created: 19-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
2MJM_A          6 MDAESIRLNNENLWAWLVRLLSKNPEWLSAKLRSFLPTMDLDCSYEPSNP-EVIHRQLNRLFAQGMATWKSFINDLCFEL 84   house mouse
8_pfamImport    1 MDPVSLQLGTRNLHGWLVRLLSRNLEWLDAKVKLFLPNVDLGSEYQALDPaQRVILHLQKLHTQGPTTWKSFIQCVCMEL 80  
XP_012409281    1 MDSLSWQNDEESLQQHLVGFLSKDLEWLILKVKFFLPDLDLTPVDDLPDPtQKVSLLLDKLRAHSLSTWRTFIHCVCMEH 80  
EMP25594      460 MEDMDLQRAIANAQPQLVESLSHTPEWLLMKAKCFLPHMDLSHVDGITDRkKKVLLLLDALENAGPIIWKQFIQCVCMEG 539 
5_pfamImport    1 MDPDSLHLGSENLCGWLVRLLSTNQEWLRAKVKFFLPDVDLASSNEALDPeQRVVLQLGKLYTQGVATWQSFIHCMCMEL 80  
4_pfamImport    1 MDSESFQLGTENLWAWLVRLLSKNSEWLNGKIRFYLPTMDLDCSNTAPEP-EVIHHQIRRLYTQDQATWQSFINSLCMEL 79  
XP_038954078    1 MDAESYRLGNENLWAWLVELLSKKPEWLSAKVRFFLPTLDPDCSNEAPIS-EVTHHQLNRLFAQGPATWESFIYTLCIEL 79  
C3VPR6          1 MDAESIRLNNENLWAWLVRLLSKNPEWLSAKLRSFLPTMDLDCSYEPSNP-EVIHRQLNRLFAQGMATWKSFINDLCFEL 79   house mouse
XP_055220274    1 MDPVGLQLGNKNLWSCLVRLLTKDPEWLNAKMKFFLPNTDLDSRNETLDPeQRVILQLNKLHVQGSDAWQSFIHCVCMQL 80  
6_pfamImport    1 MDPIGIQLDTWNQWGCLVSLLSKNPDWLSAKMKFFLPNMDLGSRNEILDPeQRIISQVRLLHTQGLATWQSFIHCVCMEL 80  

2MJM_A         85 DVPLDMEIPLVSIWG 99   house mouse
8_pfamImport   81 DVPMDMEVLLMSMWG 95  
XP_012409281   81 TMPLHLETMLLSVWG 95  
EMP25594      540 NLPMDLEIQLMSASG 554 
5_pfamImport   81 EVPLDLEVPLLSTWG 95  
4_pfamImport   80 DVPLELEVPLLSIWG 94  
XP_038954078   80 EVPLSLEVPLLSIWG 94  
C3VPR6         80 DVPLDMEIPLVSIWG 94   house mouse
XP_055220274   81 EVPLDLEVLLLSTFG 95  
6_pfamImport   81 EVPLDLEVPLLSTWG 95
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