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Pesticidal crystal protein Cry1Aa, domain IV This entry represents a domain is found in the protoxin portion of insecticidal proteins (parasporins, or Cry proteins) such as Cry1Aa from Bacillus thuringiensis (Bt) and related species. These proteins contain a proteolytically labile protoxin segment (in the C-terminal region) and a three-domain toxic core at the N terminus (domains I-III). This entry describes domain IV, one of the four protoxin domains (domains IV-VII). Domains IV and VI are alpha-helical bundles that resemble structural/interaction domains such as spectrin or bacterial fibrinogen-binding complement inhibitor. The structure of full length Cry1Aa is determined. |
Jiyao W et al.(2023). "The conserved domain database in 2023.",