Conserved Protein Domain Family
Tli4_N

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pfam18443: Tli4_N 
Tle cognate immunity protein 4 N-terminal domain
T6SS bacteria employ toxic effectors to inhibit rival cells and concurrently use effector cognate immunity proteins to protect their sibling cells. The effector and immunity pairs (E-I pairs) endow the bacteria with a great advantage in niche competition. This is the C-terminal domain of Tli4. The Tle cognate immunity proteins (Tlis) can directly disable the transported Tle protein and thereby mediate the self-protection process. The Tle-Tli effector-immunity (E-I) pairs confer substantial advantage to the donor cell during interbacterial competition. Tli4 displays a two-domain conformation (domains I and II) and contains 17 beta-strands and four helices. These two domains pack into a crab claw-like conformation functioning as an inhibitor of Tle4. Both domains adopt an alpha+beta architecture. Domain I features a central antiparallel beta-sheet sandwiched by two helices and a short antiparallel beta-sheet. This entry comprises the N-terminal domain I found in Tli4 proteins.
Statistics
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PSSM-Id: 497252
Aligned: 22 rows
Threshold Bit Score: 113.205
Created: 19-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
WP_037385315     49 KPQCIGRYIIDVPESFNNQlrDMVFIDDFKI-ESKPIYA-PAFRQRIMLREQELRDEINkpg---------------nyS 111 Serratia sp....
2_pfamImport      1 KTRCIGRYLIDMPGSMDVS--GYAKIQDVDF-NVKPMAQ-ETFRKEVAQREDSLMATQS--------------------I 56 
RR42:RR42_s0262  11 RPWCIGRLVMDRPARSGISyeKYEYWGN-KIdIARDISP-GTFRYRVDTRENELRAKRRttsissykemlakglksmivE 88 
WP_236702153     11 RPWCIGRLVMDRPARSGISyeKYEYWGD-DIeIARDVSP-GTFRHKVDTRESELRASKRiisvpltdem-mrkgdnglhK 87  Cupriavidus ...
WP_236702154     11 RPWCIGRLVMDRPARSGISyeRYEYWGD-KIdIAKDVSL-GTFQHGVDVRESELRANKRilsipltdem-mkkggnglhK 87  Cupriavidus ...
WP_005669139     51 KTVCFGRFMVDVPASATVAwgGTDVPLGVTI-YRDGV---DEVKALMQKFVDELKSEKAi------------------yL 108 Massilia
WP_056344253     51 KTVCFGRFMVDVPASAAVVwgGTDVPLGVTI-YRDSV---DEVKGLAQKFVDELKSEKAi------------------yL 108 Massilia sp....
EKU82520         59 KILCFGRYAIEVPQEAQLIpgSAVLDSGIEV-VSGGL---EKAKRRADAKIRKVKWED---------------------D 113
WP_005666286     55 KILCFGRYAIEVPQEAQLVwgSASFPSDIDI-ISGGI---EKAKRRAEEKIVKLKREK---------------------R 109 Massilia tim...
WP_013232110     42 TTFCVGRFLIDVPKGSTLS--GGNYIYDFTHiERPQALEfEEFSARLAERERLLKEEK---------------------H 98  Herbaspirill...
WP_037385315    112 ENAPFLKEVFRLSND-KGVIFDSNKSGS-DDSFRKLEAHIYVDSIAFIITTNILDLSASKYIEEKktylnsgfteaetnt 189 Serratia sp....
2_pfamImport     57 DAYPYLYTNGGEPDG-NIRYFIYRGTVHdDPGNRLIEAYKWDRGYRFRLAIEGSDFTNPDQTNDPivkqmav-----knd 130
RR42:RR42_s0262  89 TDIPLLEQAVSPTPS--SRLLIFKDLAE-EDYPFSAEGYVLAGSRMLTMKFDVQRSSGIQK------------------- 146
WP_236702153     88 SDVPWLEQAVSPTPN--SRLLIFKTKVR-EDYPFSAEGYVLAGSTMLTMKSDVQRSSGIQK------------------- 145 Cupriavidus ...
WP_236702154     88 SDVPWLEQAVSPTPN--SRLLIFKDLGR-VDYSFTAEGYVLAGSTMLTMKSRVGGSEVQK-------------------- 144 Cupriavidus ...
WP_005669139    109 NNVPLLISVDDMRQP-EGKIVTGYDGFE-AIGMLKINGYFRMNNDSVIIDARPLEEQKDE-------------------- 166 Massilia
WP_056344253    109 NNIPLLISVDEMRQP-EGQIVTGYEGFE-AMAELKISGFFRLNNDGVIIDARPLKRQKDE-------------------- 166 Massilia sp....
EKU82520        114 TAEITYSGPGPIADSwQVRYFEDKYNK--ERNALFFYTYISKGEITFVLDDSISKGENEST------------------- 172
WP_005666286    110 TSEITYNDVGPIEDSwQTRYFENEFAK--EDNSLFFDTYISKGEITFVLGDAIETGETEST------------------- 168 Massilia tim...
WP_013232110     99 NSEPSLLRVVESPDV-HSRIHVYWESAF-ITAAAEVDGYLWMDGVQFLLKTWAGTSPPPPGITSRqd------------- 163 Herbaspirill...
WP_037385315    190 kpaKLAALQSLISRLSGR 207 Serratia sp. DD3
2_pfamImport    131 vpeKTRLVLSLLESVRGR 148
RR42:RR42_s0262 147 ---VTQRSTDVYQNITYR 161
WP_236702153    146 ---FTQLTTDEYQNITYR 160 Cupriavidus basilensis
WP_236702154    145 ---FTQLTTDVHKNITYR 159 Cupriavidus basilensis
WP_005669139    167 ---TITDIKSIARRMRQR 181 Massilia
WP_056344253    167 ---VIADIKSMARRLRQR 181 Massilia sp. Leaf139
EKU82520        173 ---VIARQLARAERLRLR 187
WP_005666286    169 ---VIARQLAQAKSLRLR 183 Massilia timonae
WP_013232110    164 --yAVARMRETLANLRTR 179 Herbaspirillum seropedicae
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