8B0F,8B0G


Conserved Protein Domain Family
Kazal_3
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pfam18434: Kazal_3 (This model is not part of the current CDD release)
Kazal-type serine protease inhibitor domain
Kazal domain found in factor I-like modules (FIMs) region on the carboxyl-terminal of complement component C7 proteins. Complement component C7 is a subunit of the membrane attack complex (MAC), a fundamental machinery in the mammalian innate immunity. KAZAL domains are common in serine protease inhibitors.
Links
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Statistics
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PSSM-Id: 523280
Aligned: 20 rows
Threshold Bit Score: 57.7594
Created: 19-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
8B0F_C        791 CREASECEEEGFSICVEVNGK----EQTMSECEAGALRCRGQSISVTSIRPC 838 human
7_pfamImport    1 CKELAECLNSGINVCVRVGEDdtasTQTMSECEAGVRRCNGEKVSVVSILPC 52 
1_pfamImport    1 CKDSADCLIPGESVCIRVGEDatvaPQTMSECEAGLRRCKGEKVTVVSIQPC 52 
4_pfamImport    1 CKDSADCLNPGINVCVKVGETvtpvTQNMSECETGLRRCKGEKVSVVSIQPC 52 
10_pfamImport   1 CRENEECTKSGAHICVLAGENp--aAQSMTECEAGRRRCHGENISAVSIWPC 50 
8_pfamImport    1 CKNATECPKDSAPLCVSSGDGr--vNVTMTECEAGSRRCAGEQVTVIRIDPC 50 
XP_022531653  776 CKELQDCSESSAHLCVSVDNGa---PKPMTECEAGVWRCSGNSVRIISVGDC 824
XP_006277938  779 CREDGQCEEGGMSICIEGSENv--tNQTITECEAGLLKCQGEDVTIVSIRPC 828
KFO56780      774 CDEDGLCEEGGVQVCVEVSGSg--aRRTMTECEVGLLRCRGETVTLVSIRPC 823
XP_068782318  780 CREDGQCEEGGIRICAAVSRSa--vRQTMTECQVGLHKCRGETVTLVSIKPC 829
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