4KF8


Conserved Protein Domain Family
Nup188_C

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pfam18378: Nup188_C (This model is not part of the current CDD release)
Nuclear pore protein NUP188 C-terminal domain
This is C-terminal domain of Nup188. It is a right-handed arc-shaped superhelical structure built from 19 helices that form 6 helical repeats, which are stacked in regular order. The first helical pair (alpha1 and alpha2) forms a HEAT repeat followed by 5 ARM repeats.
Statistics
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PSSM-Id: 523240
Aligned: 39 rows
Threshold Bit Score: 435.491
Created: 19-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4KF8_A          10 LLSLVSATINGVDNPW----SKDQISYFRTLLKVLFVVLRGTKHSNNAAPQKPTA-------------ESPVAVTQLVLT 72   Thermothelom...
10_pfamImport    1 LLAPVWNAVRASTQDFdtvfSGDAVHYYRSLLRILYLALQPHLVEATEQNEEADFrssfrgtmpashkTYETSSSTLLLE 80  
EER40677       292 LLSVAWDATRFRNPSYetalLNGDTEYYGVMLNILFLALQFHVAGPSRSVPEAVSk-----------kPEVSSDLSIVLE 360 
XP_054118204  1454 LLAVVWEAMRASGTTYenalIHDNTDYYRGLLNVLFLALQFHVAKFPSAASEPVNkk---------kkPDLSPDLTIVLE 1524
XP_013325126  1527 LLEVVWEAIRARGTTYenalIHDDTEYYRSLLNVLFLALQFHVAGPARAAPEAVSk-----------kPELSSDLSIIVE 1595
XP_040636072  1449 LLKVAWDTLRTRRATYeealVNDDTEYYRSLLNVLFLALQFHVDGPSRAAPETINk-----------kAELSSDLTQVIE 1517
XP_049970059  1447 LLETVYKTLRARHRTYeealISDDTEYYRSLLNVLFLSLQFHLPGPNRANPEALSk-----------qTSVSNDLSVVVE 1515
XP_050469175  1143 LLQVVWESLRSRRPTYedalINDDSEYYRSLLNTLFLALQFHLDGGAKAARELYNs-----------kADPTPDLVIVVE 1211
XP_043149069  1445 LLRVVWDALRTRRATYeealVNDDAEYYRSVLNVLFLALQFHLDGSSRTAPETLSk-----------kAEISSDLTLVIE 1513
19_pfamImport    1 LLSIVWEAMRARGGTYenamANDDNEYYRSLLNVLFLSLQFHLDGPSRAEPEVVGk-----------kPKFSSDTSIVLE 69  
4KF8_A          73 TLDRVVARSFRNLAALVHEPDAATTPEDLALITAILQACLSVPGIEQCQLQVLNIXSSHNVLQVATSLFSWSDRLAEKG- 151  Thermothelom...
10_pfamImport   81 ILSDTIAKGFRSLANQLHADPSSVAPSDFALLTAILQRIIAIPEMSKWQTQAALLFANSGTIRYATSLFSWSDRLTISSt 160 
EER40677       361 IVKVIVAQGFRSLTTYLHDEPEKCSPRDFAILTAILQTCLRVKNSDRIYEQAAFHLADSDTPRYAATLFSWAYQLTVEG- 439 
XP_054118204  1525 VIKVVIAQGFRSLTTYLHDEPQRCSPKDFAIITAILQTALRVKDAERLYEHIVFHIEDNDTARYATTLFSWADQLTIEG- 1603
XP_013325126  1596 VVKVVIAQGFKSLTTYLHEEPQKCSPKDFAILTAILQTALRVKNAERIYEHIVYHIEDNDVARYACTLFSWADQLTVEG- 1674
XP_040636072  1518 ITKVVVAQGFKALTTYLHDDPEKCTPKDFAILTAILQTCLQVKNADRLLEHIVFHIQDNDTARYATTLFSWADQLAVAG- 1596
XP_049970059  1516 IVKTVVAQGFKSLTTYLHEQPEKCAPKDFAIIIAILQSCLQVKNADRLYEHIAFHLAENDVARHATTLFSWADQLTVAG- 1594
XP_050469175  1212 IVKTVVAQGFRSLTSYLHEQPEKCTPKDFAIITAILQSSLQVKDIDRMYEHIVYHIADNDTVRHATSLFSWADQLAVAG- 1290
XP_043149069  1514 IVKTVVAHGFRSLITYLHDQPDKCEPKDFALLTAILQTSLQIKHADRLYEHIVYHIEDNDTARHAMSLFSWADQLAVAG- 1592
19_pfamImport   70 IVKVVVAQGFRTLTTYLHDDPQKCSPRDFAILTAILQTCLQVKHVDRLYEQIAFHIEDNDTARYALTLFSWSDQITIEG- 148 
4KF8_A         152 ---DPIYGELALLLLLELSALPALAEQLACDGLLGHLTSANLAGFXRRAN-VSPFTDNAgaaRCYAIWAKGILPLLLNIL 227  Thermothelom...
10_pfamImport  161 atpDPVYGELSLLFLLSLSSIPALAETMAVDGVLSQLNTANLTSYFRRRGgMGPFDAPT---RLHSIWTKGILPLCLNLL 237 
EER40677       440 ---DPVYGELSVLFLLELSCIPMMAEQMAADGILVKLSTFRLTDVLRQPHgCGPFDPIP---RLFAIWNSGFLPLCLNLL 513 
XP_054118204  1604 ---DPVYGELSIIFLVELSAIPMLAEYLAVEVVLMKLSTSRLTRILSQAKtFGPFDPVP---RLYAIWREGFLPLCLNLL 1677
XP_013325126  1675 ---DPIYGELSIIFLVELSTIPMLAEYLAVEAVLMKLSTSRLARVLGQPRgCGPFDAVP---RMYAIWTGGFLPLCLNLL 1748
XP_040636072  1597 ---DPIYGDLSISFLVKLSTIPMLAEHLAVEGVLMRLSTCRLTNVLRQSKgFGPFDPVP---RLYTIWTSGILPLCLNLL 1670
XP_049970059  1595 ---DPIYGELSVSILVKMSTLPLLAEHLAAEGAFMRLSTCRLTNVLRQPKgFGPFDPIP---RLYTIWTGGILPLCLNLL 1668
XP_050469175  1291 ---DPVYGELSISFLAKLSTIPMLAEHLAVEVVLAQLSNCRLTNVLRQPKgFGPFDPIP---RIYAMWTGGILPLCLNLL 1364
XP_043149069  1593 ---DPVYGELSILFLVKLSTLPMLAEHLAVEAVLTRLSTCRLTNVLQQPRgFGPFDTVP---RLYTIWTAGFLPLCLNLL 1666
19_pfamImport  149 ---DPIYGELSILFLLELSTVPMLAEHLAVEAALMKLATCRLTNVLQQSKgCGPFDPIP---RLYSIWSGGILPLCINLL 222 
4KF8_A         228 GALGATIAPEVAFVLNQFPNLLRSSVDRLEAPGLSRTVp-lSsrdapgagphyFVALVALSEVHSLALLTRVLAALRS-- 304  Thermothelom...
10_pfamImport  238 LSVGPPLAAEISAFLNQFPEQLARAATALNPTPSHRTRs-------------vRITLSLASEAHSLALLAAILHNVRKqg 304 
EER40677       514 YSVVRA-APEVAAFLNQFEGQLRRASASFSFGQPTTTSplaSshlks-sqhvkKLSLSMATEACSLALISQIINKFRDag 591 
XP_054118204  1678 FNVSRA-ASEVAAFLNQFEGRLTRVAESFASIHAGTASsasSqp-------ekRICLSMASEAYSLSLISFILERYRTag 1749
XP_013325126  1749 YHVNRA-APEVAAFLNQFEGQLNRAAEAFAGGHAPVAStqsAk----------KISLAMATEASSLALISFILQRYREag 1817
XP_040636072  1671 YHVMRT-APEVAAFLNQFEGQLGRAAESFSAGRATAGT---Svpa------phRICLSMASEANSLALITFILDRFREag 1740
XP_049970059  1669 HNVVR-FAPEVAAFLNQFEGQLTRASESFSTAHATAVA---Pgpa------aqWLSLSMTSEAYSLALISFILVRFREag 1738
XP_050469175  1365 YHVIRT-APEVAAFLNQFEGQLTRAASSFASARSTVSSsa------------qGISLSMASEAYSLALISFILGRLREag 1431
XP_043149069  1667 YHVLRT-APEVAAFLNQFEGQLKRASESFVADRSGSPSr--------------RICLSMASEAYSLALISFILNRFREag 1731
19_pfamImport  223 YHVMRA-APEVAAFLNQFGGQLNRASECFAGTHAGVSTaqqAg----------QICLSMASEAYSLALISFILERFREag 291 
4KF8_A         305 ----GNARDIPEVVWDSGAVLENVEFWLASRKVLRERLLPLNPREAEWRGXK-As-eGSGCETKLEEKAVGLLEGIRDVL 378  Thermothelom...
10_pfamImport  305 pklgIQASEVALLDWDGDAVKDDVESWLSRKSALRERVLACDERELDMLRRKrH------DGNLLEECVLLELEETGKCL 378 
EER40677       592 astgVDAQNIQELNWDGTQVKDDIESLLEKRSVLRSRIVATNEKELEMSRREpLd-rSTGCQNQLEEKIVKELQMTVMCL 670 
XP_054118204  1750 psagVDSQTIQDLKWDKSQLKEDIEELLSRRSSLRARMVATSEKEAELARKKpLhasSSGAENRLEEKIVDELQAALTCL 1829
XP_013325126  1818 astgVDGQAIQELKWDKGQVKDDIEELLGRRPSLRARIVATNEKELEMARQKpQn-aASGAESRLEEKIVEELTAALTCL 1896
XP_040636072  1741 asagVDASSIQELKWDKGQVKEDIEELLERKQTLRTRIVATNDKEVEMARQKpAs-aSSGAENRLEEKIIGELGAALLCL 1819
XP_049970059  1739 asagLDTQAIQELKWDKTQVKEDIEELLGRRPALRARIVATNEKEAEWFRQKpLd-tGSSAENRLEEKVVASLKATLACL 1817
XP_050469175  1432 psmgMDAQAIQELKWDKSQVKEDIEELVERRANLRLRIVATTDKEVELARQKpVd-aASGSESRLEERIVSELKATLACL 1510
XP_043149069  1732 psagVDAQSIQELKWDKTQVKEDIEELLERRQGLRARIVATSEKEVELARQKpVn-pASGTENRLEEKIVNELKAALVCL 1810
19_pfamImport  292 psagVDIQTIQELKWDKGRVKEDIEELLGRRQTLRARIAATSEKELELARQKpLnaaTSGAEDRLEERIVNELTAALVCL 371 
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