2QVH


Conserved Protein Domain Family
Enolase_like_N

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pfam18374: Enolase_like_N (This model is not part of the current CDD release)
Enolase N-terminal domain-like
This is the N-terminal domain found in o-succinylbenzoate synthase (OSBS) enzymes (EC:4.2.1.113). Like other members of the enolase superfamily, OSBS enzymes are composed of a C-terminal catalytic (beta/alpha)7beta-barrel domain pfam00113 and an N-terminal capping domain with an alpha+beta fold that is found in the enolase superfamily. This domain is different from other enolase super family N-terminal domains such as pfam03952. This actino-bacterial N-terminal domain lacks the prototypical first two helices of the enolase capping domains. Structural analysis of T. fusca OSBS reveals that this is compensated for with an extra helix appended to the C-terminus.
Statistics
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PSSM-Id: 523237
Aligned: 60 rows
Threshold Bit Score: 74.9117
Created: 19-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2QVH_A         8 FAIPLRTRFRGITVREGXLVRGAAGWGEFSPFAEYGPRECARWWAACYEAA 58  Thermobifida fusca YX
WP_056536017   5 FAIPLTTRFRGITVREGVLLRGEAGWGEFSPFLEYDDPTAAPWLACAREAA 55  Marmoricola sp. Leaf446
WP_015770826   4 YSLPLTTRFRGITTRHGVLTHGPHGWAEFSPFEEYDDTEATAWYRCAWEAA 54  Jonesia denitrificans
WP_052138206   4 VAIPMTTRFRGITVREATLLRGPGGWGEWSPFLEYPPEVAEPWLRCAEEAA 54  Pimelobacter simplex
WP_056890253   5 YSIPLHTRFRGITVREGVLIRGEGGWGEWSPFLEYDAAEAEPWLRCAEEAA 55  unclassified Nocardioides
WP_025354188   6 YAIPMRNRFRGITERQGVLLRGESGWGEFCAFEDYTDTESALWLDCALESA 56  Kutzneria albida
2_pfamImport   2 YSIPMRTRFRGITVREGILLRGDAGWGEFCPFWDYDDAESAPWLASAREAA 52 
WP_060711039   4 YSLPMTTRFRGITVREGLLLSGPAGWGEFCPFPEYDDREAVAWLAAAREAA 54  Pseudonocardia sp. HH130629-09
WP_228102565  16 YAIPMRTRFRGITVREGMLIPGPNGWGEFCAFPEYDDREAAAWLATAVEQA 66  Nocardia seriolae
WP_022566718   8 YAIPLRTRFRGITVREGMLVRGALGWGEFCPFPEYGDREAVGWLGTAIEQA 58  Nocardia asteroides
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