4L4X


Conserved Protein Domain Family
PKS_DE
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pfam18369: PKS_DE (This model is not part of the current CDD release)
Polyketide synthase dimerization element domain
This is the dimerization element domain found in bacterial modular polyketide synthase ketoreductases. The dimerization element (DE) domain is N-terminal to the KR domain pfam08659. DE domain is necessary for KR function, presumably because the dimeric DE orients the KR domains for optimal activity within a module.
Links
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Statistics
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PSSM-Id: 523232
Aligned: 104 rows
Threshold Bit Score: 33.7525
Created: 19-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
4L4X_A         35 DAAFWTAVEDGDVSALTAALGT-----DeDS-----VAAVLPALSSWRRARKER 78   Streptomyces nodosus
WP_052482006  935 EEAFWAAVESEDLAALTGTVPSlateeArTA-----LGELLPALASWRRGHRER 983  Streptomyces physcomitrii
KJS58027      920 EAAFWAAVEDGDPAGLPATVTP-------DA-----WRAVLPGLAAWRRERRER 961 
WP_045705624   93 EAEFWAAVETEDLAALERAVPV-----D-AEa----WGPVLPGLAAWRRGRRER 136  Streptomyces rubellomurinus
WP_045704464  927 EARFWAAVEGEDLAALEQLLPV-----DgPG-----WGEVLPELAAWRRGRRER 970  Streptomyces rubellomurinus
8_pfamImport    1 EAEFWAAVERGDLAALERVVPA-----GgSG-----WGTVAAGLAAWRRSRRER 44  
WP_013285637 3998 DSAFWAAVESEDLAALAELTEQ-----D-ATeslerLGAALPVLASWRRQQRNR 4045 Micromonospora aurantiaca
WP_013005780  967 DAAFWAAVEREDVAEVAATLGV-----EaAS-----WSDVLPALSAWRRDRRDR 1010 Streptomyces
WP_010984327  937 DAAFWGAVENADLQGMAALVDG-----AePEv----WEPVVPALSAWRRGRQER 981  Streptomyces
7_pfamImport    1 DAAFWGAVERADVEGVAALVEG-----AeAGv----WEPVVPALSAWRRGRRAR 45
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