2D1C


Conserved Protein Domain Family
Isocitrate_DH_C_bact
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pfam18324: Isocitrate_DH_C_bact (This model is not part of the current CDD release)
Bacterial isocitrate dehydrogenase, C-terminal domain
This domain is found at the C-terminal end of Isocitrate dehydrogenase [NADP] from Rickettsia typhi and similar bacterial proteins. It is also found in the hypothetical protein TT1725 from Thermus thermophilus HB8. The presence of positively-charged residues in the alpha-1 helix suggests this region binds to a protein with a negatively charged region or to nucleic acids.
Links
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Statistics
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PSSM-Id: 523208
Aligned: 76 rows
Threshold Bit Score: 114.924
Created: 19-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
2D1C_A       387 RRVVGVDVFVE-TNLLPEALGKALEDLAAGtpFRLKMISNRGTQVYPPTGGLTDLVDHYRCRFLYT------GEGE--AK 457 Thermus thermop...
WP_202593699 372 KELVGVDVFID-SEHTLDLLKDKLEKDLSP--LSLSSISNRGVTAWPNPMPETFFIDNWRARFVNKi-----KGKP--IT 441 Criblamydia seq...
WP_059061950 373 QELKGIDIFIRw-DRDVELLAKQLQEASTPa-LKLKMVSNRGVKVWPNKMPETACVDNWRCRFVPT------KDGI--AS 442 Candidatus Prot...
WP_013924143 374 KTTQGIDIFVDs-NQEVEELEKKLTKVQDPd-FKLSMISNRGVRVWPVKMPETACSDSWRCRYIASk-----KGSN--LS 444 Parachlamydia a...
WP_013182775 376 KELVGVDIFIEd-VKDTKSLQEKLSKLENNh-LQLKMIANRGVTVWPNSMPETSCIDTWRCRFMASe-----KGTP--VT 446 Waddlia chondro...
WP_146677457 372 RELVGADVFCAf-TGKPDELAAKLKPCEADg-LVLEMLSNRGMKVWPGGMEETFLVDVYRCRFQIP------EGTPgaVE 443 Pirellula sp. S...
WP_048880138 377 RELVGIDVFLE-TDLDAETLGKTLEEISAYspFTLTGISNRGVTVYPPTGGQTFLVDHFAARFMLKhpislaGNTA--EG 453 Acidocella amin...
1_pfamImport   1 RELIGVDIFLE-SSLSAAELGASLTAIAEGsaLRLDSISNRGVQVWPATGGRTFLVDHFDCRFMLNe-----PAAG--NG 72 
P33197       387 RRVVGVDVFVE-TNLLPEALGKALEDLAAGtpFRLKMISNRGTQVYPPTGGLTDLVDHYRCRFLYT------GEGE--AK 457 Thermus thermop...
WP_014746856 384 REDVGFDLFFEvETADPAALGAEITALAEGspFRLKHLSNRGTAIWPGAVSRTELTPHWRARFVRRa----dAAAG--FD 457 Tistrella mobilis

2D1C_A       458 DPEILDLVSRVA-SRFRWMHLEKLQEFDGEPGFTKAQGE 495 Thermus thermophilus HB8
WP_202593699 442 SQDILDLLKKITdRGLEFVHTESLFNFDGKPGYNLAQNE 480 Criblamydia sequanensis
WP_059061950 443 PQEIVDLLSSLVqKELVVTQTAYLFAFDGQPGYTLAQDE 481 Candidatus Protochlamydia naegleriophila
WP_013924143 445 HHQIARLLQKFAdAQIDFVKTEHLCSFDGSPGYTLAQDE 483 Parachlamydia acanthamoebae
WP_013182775 447 RKQIAELLTTLAdMDVHFVQTEHLCTFDGQPGYTVSQDE 485 Waddlia chondrophila
WP_146677457 444 HKAITALMDRILkAGVEFVKMEGLFNFDGKPGFSRGQGQ 482 Pirellula sp. SH-Sr6A
WP_048880138 454 QPEISYLVQRIg-AKFSWMHIEKLQRFDGKDAFERPQGE 491 Acidocella aminolytica
1_pfamImport  73 PQGISDLVKAIg-QKHSWMHVEKLQRFDGKDAFERPQGE 110
P33197       458 DPEILDLVSRVa-SRFRWMHLEKLQEFDGEPGFTKAQGE 495 Thermus thermophilus HB8
WP_014746856 458 DAAALALIGKVg-ARHRWMHVEKLLVTDGADGFSRDQGE 495 Tistrella mobilis
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