7SBA,4TXD


Conserved Protein Domain Family
Csc2
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pfam18320: Csc2 (This model is not part of the current CDD release)
Csc2 Crispr
The Csc2 Crispr family of proteins forms a core RNA recognition motif-like domain, flanked by three peripheral insertion domains: a lid domain, a Zinc-binding domain and a helical domain. The CRISPR-Cas system is possibly a mechanism of defence against invading pathogens and plasmids that functions analogously to the RNA interference (RNAi) systems in eukaryotes.
Links
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Statistics
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PSSM-Id: 523206
Aligned: 17 rows
Threshold Bit Score: 305.428
Created: 19-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
7SBA_A         8 QFQPSFPR-----LASGHYVHFLMLRHSQSFPVFQTDGV---LNTTRTQAGLL----EKTdQ---LSRLVMFKRKQTTPE 72  Synechocystis s...
WP_026135371  10 EFQSAFPR-----LASGKYIHFILLRHSQSFPVFQTDGI---LNTARTQGGLGntdeGKK-Q---ISRLVMFKRKQTTPE 77  Scytonema hofma...
WP_007353277  12 FLQERYQE-----YPQGKYVNLILIRKTESEAIFRTEGSgepLCREFVQAGVQ----KRK-Td-pIQRVVITKRKQTAVE 80  Kamptonema
WP_015151920   9 FLAPTYEN-----FPKGRTIGMVVLRKTQSELILRTEGSgepMCSEFVQAGFQ----HKN-S---IQRLVMTKRKQVAPE 75  Oscillatoria ac...
Q8YWP2         9 VLATSYEN-----FPKGRFITLVILRTTHSETIFRTEGSgepMCSEFVQAGLE----GEN-QktiIQRLVMTKRKQVAPE 78  Nostoc sp. PCC ...
Q4J7Q2        18 FFSNLSKEdpnavIPRGRVVNVYVTLQAENELLIRHEGG---EDISLATLGSE------------KYPIILYDKIQSAWR 82  Sulfolobus acid...
WP_018666493  14 AFAEMITD-----VKKNKYIQIVILRELQSYGIFTTEGRi--LNVAETTAGVK----DNS-K---VTRVLMIKRKQVASE 78  Thermobrachium ...
GAK61499       9 YFVEAIPP-----KPMGKYAHIILVRETQSFPLFQTDGG---LNTVHVNAGLQ----DAQ-S---LIRIMLFKRKQSSPE 72 
WP_006099180  11 LFHSELPY-----KPMGKYVHFLTIRITESYPLFQTDGE---LNKARVRAGIQ----DKT-P---ISRLSMFKRKQSTPE 74  Coleofasciculus...
WP_023173331  11 YFHSAIPY-----KPMGKYVHFLTVRITESYPLFQTDGE---LNKARVRAGIQ----DDT-P---ISRLAMFKRKQSTPE 74  Gloeobacter kil...

7SBA_A        73 RLAGRELLRNL-----GLTSADKSAKN-LCEYN-----------GEGSCKQCPDCILYGFAIGDSG------SERSKVYS 129 Synechocystis s...
WP_026135371  78 RLAGRELLRGL-----SLTSADDTNKDkHCEYN-----------GEKSCKKCPDCIIYGFAIGDSG------SERSKVYS 135 Scytonema hofma...
WP_007353277  81 RRTGREDLRKQ-----NLL----------CLNE-----------DGASHPDSIDAYIYGYAVGQGG------AQKSRVIT 128 Kamptonema
WP_015151920  76 RRFGREQLRGF-----ELLYPSKNGSV--CSLN-----------TNAPCEMCIDCFLYGFAAGGGG------AQKSRVWT 131 Oscillatoria ac...
Q8YWP2        79 RRYGREHLRAH-----ELLYTNPKDGS-LCSLN-----------TNAPCEMCVDCFLYGFAAGGGG------AQKSRIWT 135 Nostoc sp. PCC ...
Q4J7Q2        83 RNLLALLRKDYdkhisEIDALRGKSNPwNCMLRptsaakreeekMGGLCRECPNCMTFGFAVAEDAk----yNLKSRVEG 158 Sulfolobus acid...
WP_018666493  79 RRTGKALRRKLie--kGLTICGRED----CSLI------------QHLCGKCPDCMLYGYAAQGGDnadtnqSRKTRVIT 140 Thermobrachium ...
GAK61499      73 RLVGRELLRRY-----GLVKGED------CDYN------------VKFCMQCPDCIYYGFAIGESG------SEKSKVFV 123
WP_006099180  75 RLVGRELLRNY-----DLVTADE------CEYN------------VSFAMDNPDCIIYGFAIGDSG------SEKSKVVV 125 Coleofasciculus...
WP_023173331  75 RLVGRELLRRY-----EIPGAEK------CEYN------------VEFSMNTPDCILYGFAIGDSG------SEKSKVVV 125 Gloeobacter kil...

7SBA_A       130 DSAFSLga-yEQSHRSFTFNAPFEgg-------tmSEAGVMRSAINELDHILPEVTFPTVESLRDATYEGFIYVLGNLLR 201 Synechocystis s...
WP_026135371 136 DSAFSLsa-yEESHRSFTFNAPFEgg-------tmSEAGEMRSSINELDHVIPEVTFPTVETLRDSTYEGFIYVLGNLLR 207 Scytonema hofma...
WP_007353277 129 EDAFSVlp-vSQVVDIRTSNALFEtgtm---rdtrDEGAEASTSLFGSEYVRPETHFLDIETLKDVTPDELFYVLGNILR 204 Kamptonema
WP_015151920 132 EDAFSLlp-tSETVAERTINAIFEtgt------mrDENGTASNALNTSEYIKPGVHFLDVVTLKDMTADEMRYVLGNILM 204 Oscillatoria ac...
Q8YWP2       136 EDAFSIlp-aSDVVGDRTINAIYEtgt------mrDEKGNASTALNTSEYIKPGVHFLDVVTLKDVTADELRYIIGNILF 208 Nostoc sp. PCC ...
Q4J7Q2       159 DLFIATtp-eQKSVVVRTFNAVDDatkt----tfiETEGTRTGSLFRLSLVKGGTLFVGKVSMKDVTPAEFSVLVLSLAT 233 Sulfolobus acid...
WP_018666493 141 DTAFSIrdygEKTVEEITLNAVD------------EETHSTGTALSSKEHIKPGVIFPCVETLVDVTEDEFLYVLANILL 208 Thermobrachium ...
GAK61499     124 DTAYSLtg-yDESHQQLSFNALYEeg-------kmTRQGETRSSFGEQDHVLPQVFFPAVITVKDPTESEFLYVLNNIRR 195
WP_006099180 126 DTAFSItp-fDESHETFTLNAPFEngtmtskgekgSKPGEVTSRINQQDHIRPQVFFPSIVTLKDPTEASFIYVFNNILR 204 Coleofasciculus...
WP_023173331 126 DTAYSIta-fDGSHERFTLNAPYEngtmaskgepgTKAGEVTSRINSQDHIKPQVFFPSIVTLKDPTEAGFLYVFNNLLR 204 Gloeobacter kil...

7SBA_A       202 TKRYGAQESRTGTMKNHLVGIVFADGEIFSNLHLT------QALYDQM--GGELN---KPISE--LCETAATVAQDLLNK 268 Synechocystis s...
WP_026135371 208 TKRYGAQESRTGTMRNYIAGIVFGDGEIFSNLHFT------QALYDAL--KGDID---APISD--VLQQVETVANNLLND 274 Scytonema hofma...
WP_007353277 205 SSRYGAVSSRIGKVKNTLAQVIFSDTEIFSTLELT------QRVYDILprDSQDEeldFPLADdvLLQAAINSSSELVQQ 278 Kamptonema
WP_015151920 205 TPRYGAVSSRIGRMENQILGIFGGITELPSSLELV------QSLYDALieAKTPLe--HPFDTdlLVRMTKDAIASWTNR 276 Oscillatoria ac...
Q8YWP2       209 TSRYGAVSSRVGRMENEILGVFGSITELPSSLELV------QATYDAL---GKPLe--HPLNInqLITASKQVIANWKNK 277 Nostoc sp. PCC ...
Q4J7Q2       234 TARIGGNTTDFGKVKIRIPAVILSPYEMSSGLDLFnsakglDSVDQVNakVRERV---KNFSKegLVYTFDDLGDLVVKK 310 Sulfolobus acid...
WP_018666493 209 TTRYGAEANRGGLIKNHIVGIYISNQEVFTNLELT------KHLYDELkdKL------DDIDLnlVKEAFNRVEDEIIKN 276 Thermobrachium ...
GAK61499     196 TKSYGAQTTRTGKVENHIVGLVFADGEIFSNLKFT------QKMYDLLkhDKDKLk--TPLNPdeVIQAAVTAMPELLKD 267
WP_006099180 205 TRHYGAQTTRTGRVRNELLGVIFADGEIISNLRWT------QAIYDQMkeKNTLPt-lDPLDEedVIDAATTAIEQLMSQ 277 Coleofasciculus...
WP_023173331 205 TRHYGAQTTRTGKLRNELIGVSFSDGEILSNLRWT------QAIYDAMkaNDTLT---DPLNEdeVIQAAARTITELLAK 275 Gloeobacter kil...

7SBA_A       269 EPVRkSELIFGAHLDTLLQEVNDIYQNDAELTKLL 303 Synechocystis sp. PCC 6803
WP_026135371 275 EPVRkTKLIFGSQLDDLVGEINALYQDEARLLETM 309 Scytonema hofmannii
WP_007353277 279 VFGQ-YQIMTDADRNSLIEEVRTIYRDPA---TFL 309 Kamptonema
WP_015151920 277 RGI--SMQLTEEQLTAVIADVDRHWDGER--ETFL 307 Oscillatoria acuminata
Q8YWP2       278 RGV--SVQLSEAELADLLTDVETHWSELER-DTFL 309 Nostoc sp. PCC 7120
Q4J7Q2       311 LTDN-GNIDHEIMLEAWKDAINLRKSIELFVQSKK 344 Sulfolobus acidocaldarius
WP_018666493 277 AF---SSVKKVDNINTFIEEFRNYIKDDTNLMEIY 308 Thermobrachium celere
GAK61499     268 DGVV-STMYAADDLDKILAEVNAILADEAQLKEVL 301
WP_006099180 278 EFIV-HTDYIGGEFQPLLNEVKTLVGSEAGIQSVL 311 Coleofasciculus chthonoplastes
WP_023173331 276 ECVV-HTDLIAEAFAPVLAEVRQLTGSEAGIRRLL 309 Gloeobacter kilaueensis
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