8PEL


Conserved Protein Domain Family
Rrp40_N

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pfam18311: Rrp40_N (This model is not part of the current CDD release)
Exosome complex exonuclease Rrp40 N-terminal domain
This is the N-terminal domain of Rrp40 of the exosome complex present in Saccharomyces cerevisiae. The RNA exosome complex is responsible for degrading RNA molecules in the 3' to 5' direction. Rrp40 is a 'cap' protein and binds the RNase PH barrel on the opposite side from the S1/KH ring. The N-terminal domain of Rrp44 forms a long beta-hairpin that is wedged in between Rrp41-Rrp42 and approaches the N terminus of the cap protein Rrp4. This domain adopts a beta- sandwich hybrid structure.
Statistics
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PSSM-Id: 523204
Aligned: 264 rows
Threshold Bit Score: 30.0052
Created: 19-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
8PEL_G        28 LRLGPGL--RHVPP-SDIIPTVAGQLI--TNLNKNSM--WVEYNSQR 67  Thermochaetoides thermophila DSM 1495
ODV86820      22 MTLGPNI--LHNIEnNNLIPTTSGFLNv-QTKKNNTIy-YIESNTKR 64 
ODV95628      22 VVLGPGVc-ISKKDnESIIPTSAGILQlqEKKNQNYI--YIESNNKR 65 
XP_018986666  23 IILGPGI--YKSPAtQEIIPVSAGLLTqgTKKAAHYI--YTENNSKR 65 
ONH68816      19 IALGPGI--YTTPTnSEIIPVQAGLLQ--VNNRS--I--HIETNGRR 57 
XP_019036380  19 LVIGPGI--HVTPItKEIIPVHSGILQ----QANNAL--HIESNSRR 57 
XP_011272527  22 LIIGPGI--YVNPInKSIIPINSGLLN--H--QANSL--YIESNSRR 60 
XP_003671395  31 LVLGPGL--YTDPKtLTIHPVNAGKLYitQNNNSNRIniHIDYESHR 75 
XP_003678575  19 TTLGPGL--YFDPVtQEIGPTNAGVEViaNTKRGQTV--YVDYDSKR 61 
XP_019022455  31 LRLGPGLflSHDPSnPAILPQKAGRLQ---NLAPNSY--YINSSQKR 72 
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