3F73


Conserved Protein Domain Family
PAZ_3
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pfam18309: PAZ_3 (This model is not part of the current CDD release)
Argonaute PAZ domain
This is a PAZ domain is found in argonaute present in Thermus thermophiles. Argonaute has a central role in the RNA interference pathway by mediating the maturation of small interfering RNA (siRNA) through initial degradation of the passenger strand, followed by guide-strand-mediated sequence-specific cleavage of target mRNA. The nucleic-acid-binding channel is thought to be positioned between the PAZ and PIWI domain.
Links
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Statistics
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PSSM-Id: 523203
Aligned: 6 rows
Threshold Bit Score: 99.9177
Created: 19-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
3F73_A       181 AWLaQGHP--LP--KRVRNAYd-----RRTWELLRL--GEEDPKELPLPGglSL-LDYHASKGRL----QGRE---GGRV 241 Thermus thermop...
WP_015195532 180 QWL-QTYPd-LSi-NWVRNTYn-----DRSWKFERI--SDENPETVMIPS--GSlADYHRNLENNqakeTEIS---NAKV 244 Stanieria cyano...
Q53W94       181 AWLaQGHP--LP--KRVRNAYd-----RRTWELLRL--GEEDPKELPLPGg-LSlLDYHAFKGRL----QGRE---GGRV 241 Thermus thermop...
Q8DKB1       210 WWL-SEYPn-IQi-KYVRNTYk----dKKKWILENF--ADKSPNEIQIEAlgISlAEYHRQEGATq---QEID---ESRV 274 Synechococcus e...
Q2JI93       194 EWL-ENYPd-VSi-EIVRNTYrtknnkYPTWEYRGIi-SNQSPREVWLAElnTSlADYHVQKYGAt--pEEVD---GSLV 264 Synechococcus s...
Q5P0R2       174 DWViRKRPewMEgiRRVRHRYvsn-gqYGTAELIGIatGRTALSTFPTPKgeVSlLGYHESKGNLp--eGEREavaASHV 250 Aromatoleum aro...

3F73_A       242 AWVAD-Pk----dPRKPIPHLTGLLVP 263 Thermus thermophilus HB27
WP_015195532 245 VYVSS-K------GNQEIPHLSTRLQP 264 Stanieria cyanosphaera
Q53W94       242 AWVAD-Pk----dPRKPIPHLTGLLVP 263 Thermus thermophilus HB8
Q8DKB1       275 VIVKKiSd----yKAKPVYHLSQRLSP 297 Synechococcus elongatus
Q2JI93       265 VQVVS-RernfrqKAEPILHLSRRLSP 290 Synechococcus sp. JA-2-3B'a(2-13)
Q5P0R2       251 VQVRY-Grd---tRAKPMEHLAALLQP 273 Aromatoleum aromaticum EbN1
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