Conserved Protein Domain Family
R2K_2

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pfam18299: R2K_2 
ATP-grasp domain, R2K clade family 2
Family of ATP-grasp enzymes belonging to the R2K clade, wherein one of the absolutely-conserved lysine residues has migrated to the RAGYNA domain which is a part of the core ATP-grasp module. This family is predicted to catalyze peptide ligation reactions on protein substrates in biological conflict contexts, probably between bacteriophages and their hosts.
Statistics
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PSSM-Id: 497125
Aligned: 38 rows
Threshold Bit Score: 128.104
Created: 19-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
KJK56888         78 FTGRRITLTTLSQA--------WTANr--pLFVKPPSD-----K-QFPAAVYADGT--RLPRDg----ERIGPDTPVLVS 135
WP_012166516     93 FLGRAFLFAPFGALpnlplqrmFGDN----IFVRSDTNy----K-LFPAEVLKTQElsHWVKT-----FSHHQNELAVVS 158 Acaryochlori...
WP_064015443    137 FGARAVIVKDYVKS--------RKHEwndaCFIPDASEtaaalK-VIQTFVSRQGS--EFQGGvvlraFESFMPLAQHSK 205 Deinococcus ...
WP_007904573    137 FAGRPVIVKDFVKS--------RKHEwgeaCYIPSASDrqsveR-VVTRFLQLQGA--DLNEGlvfreFVEFEPLTTHSK 205 Ktedonobacte...
WP_015208336    136 FNSQPIVVKDFVKS--------RKHEwqeaCYIPSASDissveR-VVRRFIELQGN--QLSEGlvfreFIEFERLTQHSK 204 Cylindrosper...
PEL:AKJ09_03737  98 FARREIRILPLADL--------KADAf--pVFVKSVIP-----K-QFKSAVYDSEA--SLTAEt----QGLAASEEVLVS 155
WP_013628418     79 YTRRSIELMRLGEA--------RVIRr--pAFIKPPND-----K-LFEARVYRTGE--ELP-------VDFDEELSVLVS 133 Rubinisphaer...
WP_015161990     81 FRKRWGSLSTLEAC--------RELVe--pAFIKPPND-----K-SFPARVY-TGA--ELP-------LEYDNDTPVLVA 134 Chamaesiphon...
WP_007316685     70 FLKRTVRLCRGRDL--------TSTDt--pAFVKLADAk---vAeLPAGSGTEDGL--RQSLV-----ALDALDSWTIVS 129 Gordonia effusa
KDN88049         85 LTGRTVELTTLGAA--------RRLTr--pAFVKAPAD-----K-HFAARVYRDGG--GLPGP-----ELLDDDTPVLVS 141
KJK56888        136 DVVTFAFEYRLFVLDGRIATGSRYARFGRL----DVAAldgdsherevrAFTDALLRTHRGS--LPSAVVVDVGLSQDpd 209
WP_012166516    159 EVVSFEAEYRCFCRNGIFFCGSSYPDEPYS----EVPQei--------rSVAESVAQALDVT--GMNMLTVDIGIHAG-- 222 Acaryochlori...
WP_064015443    206 SGMPLTREYRLFVADGQIISADEYWEEGDY-----PAG-----------AVPLELFEAVGRQi-QSRFFTVDIAQHTDg- 267 Deinococcus ...
WP_007904573    206 SGMPLIKEFRLFVLDGQIISSTPYWEEGNY----GNDKyef-----ppiDLFDHVVQKIQ-----SRFFTMDVAKKRDg- 270 Ktedonobacte...
WP_015208336    205 SGMPLTKEFRIFFLDGEPIYTVEYWEEGNYqg-iTPPI-----------DQFRQIAKSVQ-----SRFFTMDVAKKLDg- 266 Cylindrosper...
PEL:AKJ09_03737 156 SVVTFVAEARAFVLDGSVRACAIYEGEASA----ADAA-----------RFAERIVSTMGAPt-FPRTCVVDVGLMEDg- 218
WP_013628418    134 TPVEWAVEFRCFCLDGQIETVSPYLRDGKLaclsHFESsslel--eavhSFTADVLAASKSS--RPRACVVDIGLLQSg- 208 Rubinisphaer...
WP_015161990    135 EVVAWEKEFRCFVLDRQIRAISVYLRNGELqrdrDFAAadael--aeveSFVDLVLADTRIE--LPRTAVLDVGVICDr- 209 Chamaesiphon...
WP_007316685    130 ELIDLVEEWRVLIVDGTAIDSSQYVRASRSietkLPTFrd-------ieEFASAAAQSDPGH--LPASYMLDVGITTTg- 199 Gordonia effusa
KDN88049        142 EVVRFAAEYRLFVLDGAVRAASRYACDGEL----SVGApgsdg--pelsAFAAEVLAAAAGCapLPSAAVVDVGRTPA-- 213
KJK56888        210 tggeRWAVVEANMPWFAHS-YAADPDQVLEV 239
WP_012166516    223 ----EPKLVEIGGVNSWGI-YGSNVADFIAA 248 Acaryochloris marina
WP_064015443    268 ----QWRIMELGDGQVAGLpERADRNTFYAA 294 Deinococcus puniceus
WP_007904573    271 ----AWNIVELGDGQVAGLpARADTKAFYQA 297 Ktedonobacter racemifer
WP_015208336    267 ----EWMIIELGDGQVAGLpEKADVLSFYQM 293 Cylindrospermum stagnale
PEL:AKJ09_03737 219 ----QWALVECNAPWGAGL-NGCDPAPVLAC 244
WP_013628418    209 ----KWAVVEANAAWGSGL-YGCNPSQALNV 234 Rubinisphaera brasiliensis
WP_015161990    210 ----GWAVVEQNAAWGAGL-YGCDPVRVLEV 235 Chamaesiphon minutus
WP_007316685    200 ----DLTIIEANPIWCANW-YSLSTENVKQA 225 Gordonia effusa
KDN88049        214 ----GWAVVEANAAWASGG-YACDPDAVLEV 239
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