Conserved Protein Domain Family
IL4_i_Ig
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pfam18258: IL4_i_Ig 
Interleukin-4 inducing immunoglobulin-binding domain
This domain is found in Interleukin-4 inducing protein alpha-1 (IPSE/alpha-1) present in Schistosoma mansoni, a parasite of humans. IPSE/alpha-1 triggers the release of IL-4 from basophils in the liver which is a major site of egg deposition during S. mansoni infection. This domain adopts a beta gamma-crystallin fold that is stabilized by three disulfide bonds within the domain (23/26, 59/93, and 111/121). The domain is involved in immunoglobulin binding.
Links
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Statistics
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PSSM-Id: 408073
Aligned: 7 rows
Threshold Bit Score: 138.769
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
VDP54827  53 CLRLYSEINQNGYWSDICDSNELLSPYLMMTTQSICAPANVWYKTPRYWLAYQQPYYSGSYILLKPGQCVKNVRAYGLLS 132
VDQ00466  52 CLRIYSEAFRNGFWSDFCNSNELLSPFQIWTTLSMCAPQNVWYKQSRYWVAYEQPGFLGSYLFLKPGECINNVRQYGLKS 131
VDL91751  51 CLRLYQQRWKTGDWADFCNSNELLPSCFFWNSGSACAPPQQWWQRQTYWLLFEGPFFNGRYALLQAGECKQDLRRMGLQS 130
VDQ00065  74 CLRLYSEVNRRGYWSDMCDSNEALSPLQVWSTGSLCTPGYQLHGRSSYWLIYEYNNFRGRYLLLSPDMCIYNVHRYGIRT 153
VDQ02880 178 CLRLYSEANRRGYWSDMCDSNEALSPLQVWNTRSLCSPGYQLHGRSSYWLIYEQPHFTGPYILLGPDRCVDNVYKYKLIS 257
VDP53234 104 CVRLYMEPNQLGDWFDICDSNELLSSTFVWRTRSICTPGNTNSFKKTYWLIYERSHFAGPYILLGHSKCIDDINQYKLLA 183
VDP99569  60 CLRLYSEINLRGSWYDMCDSNEAISRKQAWNTRSACSPEM-------VW----RPEFYGRYLLLSPGQCIYNIPQYGLKR 128

VDP54827 133 IGSILQCAQ 141
VDQ00466 132 IASIVECVQ 140
VDL91751 131 VGSVLICEQ 139
VDQ00065 154 TSSILKCVQ 162
VDQ02880 258 ISSILTCTQ 266
VDP53234 184 TMSILICVE 192
VDP99569 129 VSSIVKCTQ 137
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