Conserved Protein Domain Family
HMw1_D2

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pfam18254: HMw1_D2 
HMW1 domain 2
This domain is found in Actinobacillus pleuropneumoniae HMW1C (ApHMW1C). HMW1 adhesin is an N-linked glycoprotein that mediates adherence to respiratory epithelium through N-glycosylation of protein acceptor sites and O-glycosylation of sugar acceptor sites. This domain forms an all alpha domain (AAD) when combined with the N-terminal domain. The AAD interacts extensively with the C-terminal GT-B fold in order to create a unique groove with the potential to accommodate the acceptor protein.
Statistics
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PSSM-Id: 497095
Aligned: 3 rows
Threshold Bit Score: 195.97
Created: 19-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
WP_003788513 160 DSLWSVNPSLTASLCFAWQSPRFIATEAAFNRRAQVLQWFPAKLAQFNNLNTLPANISHDVYMHCSYDIEPNKHDVKGAL 239 Kingella kingae
1_pfamImport   1 DAIWQLNPTLCASMCFALQSPRFIGTKEAFGKRGAILQWFPEKLAQLPNLDNLPSSISHDVYMHCSYDVAANKHDVKRAL 80 
Q7VKK3       155 DAAWNVDPELCASLCFALQSPRFLGTVAAYSKRSAILQWFPEHLAQLANLDNIPSAISHDVYMHCSYDIAENKHAVKKAL 234 [Haemophilus] d...
WP_003788513 240 NQVIRRHI 247 Kingella kingae
1_pfamImport  81 NQVMRRHL 88 
Q7VKK3       235 NQVIRRHV 242 [Haemophilus] ducreyi
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