4OOJ,6CP0


Conserved Protein Domain Family
SidC_N
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pfam18219: SidC_N (This model is not part of the current CDD release)
SidC N-terminal domain
This is the N-terminal domain of SidC present in Legionella pneumophilia. SidC appears to be involved in modulating mammalian trafficking by promoting the communication between ER-derived vesicles and the Legionella containing vacuole. The N-terminal domain (SidC-N) has a novel fold with 4 potential subdomains. SidC-N does not show structural similarity to any known protein domain in the protein data bank.
Links
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Statistics
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PSSM-Id: 523169
Aligned: 8 rows
Threshold Bit Score: 643.389
Created: 19-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
4OOJ_A        11 IKFKEPERCDYLYVDENNKVHILLPIVGGDEIGLDNTCQTAVELITFFYGsAHSGVTKYSAEHQLSEYKRQLEEDIKAIN 90  Legionella pneu...
WP_238584058   3 LPLKEPLSARYLYLSPENIVYIFMPIVSGTAIGLDNTCKAVYALQEFFDK-GSNSNKKASLKVELLAYKEALESDMSLLG 81  Legionella tucs...
WP_045096653   3 LPLKEPLFARYLYVSPENIVHVFMPIVSGTNIGLDNTCKAVYALQEFFGK-GSNSNKKASLKTELLAYKEALESDINLLG 81  Legionella fall...
WP_052679530   3 LPLKEPLSAKYLYISPENIVHVFMPIVSGTNIGLDNTCKAVYSLQEFFGK-GNNSNKKSTIKGELLAYKEALESDISLLG 81  Legionella micd...
WP_231865908   3 LPLKEPLFGKYLYISEDNIIHVLMPVVSGTSIGLDNTCKAVLSLQEFFGK-GSNSNQKATLKGELLKYKGALENDLSLLN 81  Legionella fall...
Q5ZSK7         8 IKFKEPERCEYLHIAKDNKVHILLPIVGGDEIGLDNTCETTGELLTFFYG-KTHGGTKYSAEHHLNEYKKNLEDDIKAIG 86  Legionella pneu...
Q5ZSK6         9 IKFKEPERCDYLYVDENNKVHILLPIVGGDEIGLDNTCQTAVELITFFYGsAHSGVTKYSAEHQLSEYKRQLEEDIKAIN 88  Legionella pneu...
6CP0_A         8 IKFKEPERCEYLHIAKDNKVHILLPIVGGDEIGLDNTAETTGELLTFFYG-KTHGGTKYSAEHHLNEYKKNLEDDIKAIG 86  Legionella pneu...

4OOJ_A        91 SQ-KKisphayddLLKEKIERLQQIEKYIELIQVLKK----QydeqNDIrQLRTGGIPQLPSGVKEIIKSSE--NAFAVR 163 Legionella pneu...
WP_238584058  82 AT-SP--------LMQQKQERLTQIDAYLTLLASVEK----H----PEL-NCLNTGFPSYPRPLEGMMQDRAtsNLYSMV 143 Legionella tucs...
WP_045096653  82 AE-SS--------LTQQKQERLVQIDAYLKVLVSVEN----H----PEL-SCLNAGFPSYPRPLEELMQDRDtsNLYSMI 143 Legionella fall...
WP_052679530  82 AD-AL--------LTQSKQERLTQIKAYLKVVRHLEN----H----PEL-DCLNQGFPSYPRPMEELMQDRTtsNLYSMV 143 Legionella micd...
WP_231865908  82 KD-AL--------LTKQKQERLTQINAYLKVITALEH----H----KEL-ECLNQGFPSYPRPLEELMQNREtsNLYSMV 143 Legionella fall...
Q5ZSK7        87 VQrKIspna-yedLLKEKKERLEQIEKYIDLIKVLKEkfdeQ----REIdKLRTEGIPQLPSGVKEVIKSSE--NAFALR 159 Legionella pneu...
Q5ZSK6        89 SQkKIspha-yddLLKEKIERLQQIEKYIELIQVLKKqydeQ----NDIrQLRTGGIPQLPSGVKEIIKSSE--NAFAVR 161 Legionella pneu...
6CP0_A        87 VQ-RKispnayedLLKEKKERLEQIEKYIDLIKVLKEkfdeQ----REIdKLRTEGIPQLPSGVKEVIKSSE--NAFALR 159 Legionella pneu...

4OOJ_A       164 LSPYDNDKFTRFD--DPLFNVKRNISKYDTpsrQAPIpiyeglgYRLRSTLFPEDk-TPTPINKKSLRDKVKSTVLSHYk 240 Legionella pneu...
WP_238584058 144 LHPSEQDGYLRTEgtNPVFRVAHKSVSRNI---EHAE-------SNLQKALIKAY--SPLIFTVQNVKAEVRHQVLAQFk 211 Legionella tucs...
WP_045096653 144 LRPTAEDGFLRSEatNPIFSVAHKSVSKQI---HTSK-------SALQHALIQAY--TPLTFEAKNLKSRVIKQVAQLM- 210 Legionella fall...
WP_052679530 144 LRPAEEDGFLRSEaaKPVFSVAHKSVARQI---EHAV-------SPLQQELTQAY--TPLIFEAKDLKSQVIQQTLARLv 211 Legionella micd...
WP_231865908 144 LRPTEEDGYLRSEaaNPIFSVAHKSVARDI---KESV-------SPLQQALIKAY--KPLTYKARDLKSQVIETALAPLk 211 Legionella fall...
Q5ZSK7       160 LSPDRPDSFTRFD--DPLFSLKRNRSQYEAggyQRATdg---lgARLRSELLPPDkdTPIVFNKKSLKDKIVDSVLVQLd 234 Legionella pneu...
Q5ZSK6       162 LSPYDNDKFTRFD--DPLFNVKRNISKYDTpsrQAPIpiyeglgYRLRSTLFPEDk-TPTPINKKSLRDKVKSTVLSHY- 237 Legionella pneu...
6CP0_A       160 LSPDRPDSFTRFD--DPLFSLKRNRSQYEAggyQRATdg---lgARLRSELLPPDkdTPIVFNKKSLKDKIVDSVLVQLd 234 Legionella pneu...

4OOJ_A       241 ------D-EDRIDGEKkdeklnelITNLQNELVKELVKSDPQYSKLSLskdprGK-----EINYDYLVNSLMLVDNdSEI 308 Legionella pneu...
WP_238584058 212 ------AqNMPCSVDI--------IASLLQETIQRQMHVTVDFSKTAK-----GE-----PITQDFIAKAMLFDKE-TSP 266 Legionella tucs...
WP_045096653 211 ------PpNKPIDFEH--------LRAVLKKTTQTLLNVDVDFTKTQQ-----GT-----LIHQQEINKAMGFNPQtTSA 266 Legionella fall...
WP_052679530 212 ------PpKMPVDFER--------LRQILQETVKALLNVEIDFTKTQQ-----GS-----SINQQYIDKAMGFNPQtTNP 267 Legionella micd...
WP_231865908 212 ------PlELPVDFKK--------LRAILQKTVQDLLNVSIDFTKTKQ-----DA-----ALEQKDIDEAMLFDVE-TTP 266 Legionella fall...
Q5ZSK7       235 kdfntkDgDRGQKFED--------IKKLVLEEYKK-IDSELQVDEDTY-----HQ-----PLNLDYLENIACTLDDnSTA 295 Legionella pneu...
Q5ZSK6       238 ------KdEDRIDGEKkdeklnelITNLQNELVKELVKSDPQYSKLSL-----SKdprgkEINYDYLVNSLMLVDNdSEI 306 Legionella pneu...
6CP0_A       235 kdfntkDgDRGQKFED--------IKKLVLEEYKK-IDSELQVDEDTY-----HQ-----PLNLDYLENIACTLDDnSTA 295 Legionella pneu...

4OOJ_A       309 GDWIDTILDATVDSTvW--------VAQASSPFYDGakeissdRDADKISIRVQYLLAEANIYCKTNKL--SDANFGEFF 378 Legionella pneu...
WP_238584058 267 EEYVDALLGFCANDL-F--------TTVPISPFKYL-------TNFESWSIATQFLLGLTNIYAVVQGKtsQDTNFGEIL 330 Legionella tucs...
WP_045096653 267 EEYMEALFGYCAGGL-F--------DSLIESPFKCL-------TQAEDWSIATQFLLGITNIYCLAQGIisPSTNFGQIL 330 Legionella fall...
WP_052679530 268 NEYMEALFGYCAGDL-F--------DTLIESPFNRL-------TQVEHWSIATQFLLGITNIYCVSQGKisPDTNFGRIL 331 Legionella micd...
WP_231865908 267 KEYIDALLAYCAPDL-F--------KTVLESPFNSL-------TQAEDWSIATQFLLGITNIYCVSQDKvsKDTNFGKIL 330 Legionella fall...
Q5ZSK7       296 KDWVYGIIGATTEADyWpkke-sesGTEKVSVFYEKqkeikfeSDTNTMSIKVQYLLAEINFYCKTNKL--SDANFGEFF 372 Legionella pneu...
Q5ZSK6       307 GDWIDTILDATVDSTvW--------VAQASSPFYDGakeissdRDADKISIRVQYLLAEANIYCKTNKL--SDANFGEFF 376 Legionella pneu...
6CP0_A       296 KDWVYGIIGATTEAD-YwpkkesesGTEKVSVFYEKqkeikfeSDTNTMSIKVQYLLAEINFYCKTNKL--SDANFGEFF 372 Legionella pneu...

4OOJ_A       379 DKEPH-ATEIAKRVKEGFTQGADIEPIIYDYINSNHAELGLKSPLTGKQQQEITDKFTKHYNTIKESPHFDEFFVADPDK 457 Legionella pneu...
WP_238584058 331 DKRPDlSTELAQILAKAQQDNANIEEACLLWINKRTHELKLMTAFTPEDLKTIKQNFAQQYVQIKDSPHFDEFFVLDTEK 410 Legionella tucs...
WP_045096653 331 DAHSSlSVHLAQTLAQAHQSNRSIEEACLLWINEHVNELALTRLLTQADINNIQETFVTRYSEIKDSPHFDEFFVLDTQK 410 Legionella fall...
WP_052679530 332 DAHPNlNIHFAQTLAQAQQSNSSIEEACLLWMNDHAKELDLTHPLTQEDIKSTTETFVKRYAEIKDSPHFDEFFILDTQK 411 Legionella micd...
WP_231865908 331 DNNPElNKDLAQTLAKAQKAHKRIEKTLLSWINEHAKELMLKKNVTQEEVKLITERFTVLYAQIKDSPHFDEFFICDSQK 410 Legionella fall...
Q5ZSK7       373 DKEPH-ATEVAKRVKEGLVQGAEIEPIIYNYINSHHAELGLTSELSSKQQEEITEKFTQRYHIIENSPHFDEFFVADPDK 451 Legionella pneu...
Q5ZSK6       377 DKEPH-ATEIAKRVKEGFTQGADIEPIIYDYINSNHAELGLKSPLTGKQQQEITDKFTKHYNTIKESPHFDEFFVADPDK 455 Legionella pneu...
6CP0_A       373 DKEPH-ATEVAKRVKEGLVQGAEIEPIIYNYINSHHAELGLTSELSSKQQEEITEKFTQRYHIIENSPHFDEFFVADPDK 451 Legionella pneu...

4OOJ_A       458 KGNIFSHQGRISCHFLDFFTRQTKgKHPLGDLASHQEALQEGT--SNRLHHKNEVVA 512 Legionella pneumophila subsp. pneumoph...
WP_238584058 411 EGAFVMHQGSICTSFAKFVSSPLL-DVPQELIQPFEKVQQQASrlGVNIPHKNTLMQ 466 Legionella tucsonensis
WP_045096653 411 KGDFVRHQGFICTSFAEFVHSPLL-DVPQEVTQALEKARSGAQslGVNIPHKNPLVQ 466 Legionella fallonii
WP_052679530 412 KGDFVIHQGSICTSFAKFVSSPLL-DVPQELNQPLEEARSHVGslSVEIPHKNPLVQ 467 Legionella micdadei
WP_231865908 411 KGDFVIHQGSIGTSFAQFACSDLF-ELSKELIEPLQKARKEARklNTEIPHKSPIVQ 466 Legionella fallonii
Q5ZSK7       452 KGNIFSHQGRMSCHFLDFFARQTKgKYPLGDLAGHQEALQAGT--SNRLHHKNEVVA 506 Legionella pneumophila subsp. pneumoph...
Q5ZSK6       456 KGNIFSHQGRISCHFLDFFTRQTKgKHPLGDLASHQEALQEGT--SNRLHHKNEVVA 510 Legionella pneumophila subsp. pneumoph...
6CP0_A       452 KGNIFSHQGRMSCHFLDFFARQTKgKYPLGDLAGHQEALQAGT--SNRLHHKNEVVA 506 Legionella pneumophila
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