4NV1


Conserved Protein Domain Family
N_formyltrans_C

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pfam18216: N_formyltrans_C 
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N-formyltransferase dimerization C-terminal domain
This is the C-terminal domain of N-formyltransferase found in Francisella tularensis. N-formylated sugars are observed on O-antigens of pathogenic Gram-negative bacteria. This C-terminal domain is responsible for dimerization. In particular, the beta hairpin motif present in the domain helps create a subunit-subunit interface. The dimeric interface is characterized by a hydrophobic patch formed by Ile 195, Leu 197, Val 201, Met 203, Ile 207, Phe 223, Val 231, Val 233, Leu 235, and Leu 237 from both monomers.
Statistics
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PSSM-Id: 436351
Aligned: 8 rows
Threshold Bit Score: 77.7808
Created: 19-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4NV1_C       190 DYKNMCEIDLDKIVTMREAIDYLRAMTHPPYKNSYFID-EhGNKVFVALELEK 241 Francisella tularensis subsp. tularensis S...
WP_013879879 174 DFKELCRLDPDETVRVKEFLDRLRALTFPPYDNAEIEV-D-GETYYVDIDITK 224 Halopiger xanaduensis
WP_013452744 188 DFKNLSEIDLDKKVSFREALDFLRAMTHGDYKNAYFID-KkGDKVFVSIKLNK 239 Marivirga tractuosa
Q5NF01       188 DYKNMCEIDLDKIVTMREAIDYLRAMTHPPYKNSYFID-EhGNKVFVALELEK 239 Francisella tularensis subsp. tularensis
WP_057953050 203 DYEESNYIELDKKVTFGEVIDYLRGKTFQDKSPAFYIDrNtNEKIFVSIKFTK 255 Salinivirga cyanobacteriivorans
WP_012609775 199 DLKTIQEIKPNKLYTARELVDVIRARTFEPHPGAHMVV-D-GKKVFMRLELYY 249 Desulfatibacillum aliphaticivorans
WP_013259561 199 DVKKIDHIDLDKSYNARELIDILRARTFPPHAGAYFVE-N-GRRVYVSLQLSH 249 Desulfarculus baarsii
KQS37791     204 DFKELCKLNLEEKLTMLEAINRLRALSHGELNNAYFIDpDtGQKIFVTLNLKY 256
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