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Bacterial HORMA domain 2 Family of bacterial HORMA domains found in conserved genome contexts with Pch2/TRIP13 P-loop NTPases. Acts as a 'third component' in broad class of conflict systems reliant on the production of second messenger nucleotide or nucleotide derivatives. Together with Pch2/TRIP13, could act as co-effectors or in regulation of other effectors of the systems. This domain found in bacterial proteins from the cyclic-oligonucleotide-based anti-phage signalling system (CBASS), such us CD-NTase-associated protein 7 from P. aeruginosa (Cap7), which is part of the type III-CBASS. CBSSs are a family of defence systems against bacteriophages. |
Jiyao W et al.(2023). "The conserved domain database in 2023.",