Conserved Protein Domain Family
GNAT_C

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pfam18164: GNAT_C 
GNAT-like C-terminal domain
This is the C-terminal domain found in N-acyltransferase (NAT) proteins present in Actinoplanes teichomyceticus. In this organism, NAT proteins are responsible for N-acylation in the synthesis of the antibiotic teicoplanin. The C-terminal domain undergoes a substantial conformational change upon binding to Acyl-CoA. The C-terminal domain is considered Gcn5-related N-acetyltransferase like (GNAT-like) but differs from the canonical GNAT fold in that it lacks the first beta strand and has an additional four alpha helices.
Statistics
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PSSM-Id: 497044
Aligned: 27 rows
Threshold Bit Score: 142.394
Created: 19-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
WP_062490572 141 IFRLGRLQFMPrtcylkikvfrnrdsgalvalsdtgvafradgqidgtngvtdpdgrweavytndgR------------- 207 Paenibacillus s...
1_pfamImport   1 LFRLGRLQFEP-------------------------------------------------------Vvi----------- 14 
WP_022068123 122 LFRLGRLQFEK-------------------------------------------------------Teslwefeykgrkt 146 Blautia sp. CAG...
WP_009004697 120 VFRLGRLEYET-------------------------------------------------------Aka----------- 133 Clostridium sp. D5
WP_023355917 134 LYRFGRLQFEP-------------------------------------------------------D------------- 145 Catonella morbi
2_pfamImport   1 LFRLGRLQFEK-------------------------------------------------------D------------- 12 
CDA62493     131 LFRLGDLECEL-------------------------------------------------------Ct------------ 143
WP_033512295 157 LFRLGSLEFEF-------------------------------------------------------Vqdpeh-----sps 176 Bifidobacterium...
CCY90616     109 LFKIGRLQFQI-------------------------------------------------------Ykapmgpdyiklpf 133
CCX37116     137 IVKLGRLEFEN-------------------------------------------------------Ity----------- 150
WP_062490572 208 -TasgnqiwpqgyadrrrveldllqwelvleeGDWVLDVHIPA-GCPMTHGLCRDSYRQAAAFVREYMSGRDIKAFVCHS 285 Paenibacillus s...
1_pfamImport  15 kEflqgkd-------------------rtiaaGTHVLNVHIPA-GVPLKYEECEESFAWSTRFFEGG-----YEAYICES 69 
WP_022068123 147 aV------------------------------GDPVISIHIPE-GQPLDPEACRESLDMGRKFWGGEIP------YVCHS 189 Blautia sp. CAG...
WP_009004697 134 eQeisghg-------------------iriepGEEIIYIHIPE-GGPLDKMACEESIEKAYQWFGTE------RKYICHS 187 Clostridium sp. D5
WP_023355917 146 -K------------------------------STDIVHIHIPE-DKSLDVNECINNINLANEFFDRY------SGFDCES 187 Catonella morbi
2_pfamImport  13 -T------------------------------AEKSIHIHIPE-GGTLSPKACGESIQQARGFFGDS-----YKLFDCES 55 
CDA62493     144 gE------------------------------GERVISLHIPS-DADLLPAAVDRSLGQIGSFVQRYFPQWAAAPMVCDS 192
WP_033512295 177 dA------------------------------SGPIIDMHIPS-DADLRDEAVNSSLQQWNAFTGQHFPQWHDIAKHCTS 225 Bifidobacterium...
CCY90616     134 kR------------------------------GDNLLYIHIPQ-GEKLTRESCTDSVRRAEEFFRSHFPNYEYDYFFCES 182
CCX37116     151 kEetpyvwg-----------------dyiirpGDPVKSVHIPSsGEPFDEAARLDSYKRAYDFFKDELQG-KPLVCVCDS 212
WP_062490572 286 WLLSPQLGRILPETSNIVKFQRDYRLVPVLS-DDHQLFERVFGLK-TTDLSGLPRDTTLRRRVLEYLSAGNVIHGAAGFM 363 Paenibacillus s...
1_pfamImport  70 WLMSPHLREMLPSDSNIIRFQEMFEVVKVHY-DYPQAEQRIFGDV-LEDKERYPEDTSLRRAAKQYLMSGKDIGIGIGVI 147
WP_022068123 190 WLLFPGLKELLDEKSNILRFQQMFEIQSVDF-QFREGEERIFDCL-MEDPEKYPENTSLQRNARKYLKQGGRLGSGLGVI 267 Blautia sp. CAG...
WP_009004697 188 WMLYPGLNEILAAESNIIRFQSRFQLIKTDF-LEREAEKRIFGWI-AERITEYQENTTLQQKARQYLLEGKALGNGCGLL 265 Clostridium sp. D5
WP_023355917 188 WILSPNILSLLPKESNIRKFQALFDVQHIKY-DFEQASERVLNEA-YSR----GQKSSLYQKLKEYVKENGDPGIGYGVY 261 Catonella morbi
2_pfamImport  56 WLLSPVLLELLNAESNIIRFQKRFRVLRVNK-KVRQAEERVFGEI-RVDKQLYPENTALQKSLKRCLLNGRNPGVGYGIL 133
CDA62493     193 WLLSPALRPMLSQSSNIRAFAARFTIKEYRS-QDKEFFRWLFAVDtNTPLEQLPEQTGLQRAAKAYLQAGGSIGAAYGVM 271
WP_033512295 226 WMLSPALDQLLPESSHILAFQRRFRQIGFDA-DAPDWREWVFDAD-PAPIAQLPERTSLQRSMKRFILQGGKIGVASGIL 303 Bifidobacterium...
CCY90616     183 WLLFPGNRSFMAKDSNIVKFMDLFTPAYSTe-NDSQAIERIFGER-KNDINDYCEDTSLQKSAKEYMLGGNKLGFGTGYI 260
CCX37116     213 WLLYPRNREILSPTSNIVSFSHDFDVIRWKEqEEFHDAWRVFGAEyQKPATDLPENTSMQRAFKKWLVEGNQTGSGFGVL 292
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