Conserved Protein Domain Family
S_2TMBeta

?
pfam18153: S_2TMBeta 
SMODS-associating 2TM, beta-strand rich effector domain
Predicted sensor/effector coupled domain which occurs in conserved genome contexts with the SMODS nucleotide synthetase. In addition to the predicted pore-forming 2TM region, the domain contains seven predicted beta-strands, suggestive of a lipocalin-like beta-barrel structure which could act as the sensor which activates the pore-forming effector response.
Statistics
?
PSSM-Id: 407984
Aligned: 16 rows
Threshold Bit Score: 145.947
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
?
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
PRJNA305460:AT984_08005  24 LAILSSSISAGLVFVLLQAQNYAQtmgldvnLPPI-----VLSLVGag---aVYTVLFWLLKNHAWKWRPLSAL--LKVP 93 
CCW33854                 18 IGIISVAIDYVIHWFFQTRNVQIP-------WWVD-----APGVLG------IAGGLYEVFEKWLWTIPLLRSIgiVKVP 79 
WP_000530048             23 VYSLATFISWILIYFLLKFLGGLSp------YWNV-----IISSAIta---lLFLTFYFLFDKWIWKTGLFFKI--LKYP 86  Acin...
EPF71573                 27 AAFLAGVLSLILIRYFSWFPNIPN-------IPNF-----ISTAFLta---lLFFILYYSFNHWIWKSKYISKY--LKFP 89 
CBH22627                 18 ITIFAVMLSTWLNLSIDLFEKMMG----------------RPVSVTvst-vaVAGALYFIFSKYVWKWELFRII--FKYP 78 
CCK75893                 18 LGFISISIAGGISQILALASNLSG-------VDAF-----AKATITtg---iVYLVLHWFFNKWVWKIPY------FEVP 76 
WP_046350672             24 LSIVSSVISAGLVFSLLSVVDLAKtsglnvnVPPA-----VLSLLGag---mVFGGLCWILSKYAWKWPLIDRL--LKVP 93  Jant...
WP_009582362             16 LAFGTYVILFLLTQDLDSIDFNKA--------LSH-----ISTTIS------LNIIVWLIFIKWAWKLKIFYPWl-VPFP 75  Fulv...
CDG17395                 14 INLTSIIIIYILSTYLIYFFSNNEis---ltLLSK-----GLSVTT------ILIILLGFFWRKIWKHIPILSK--ILFP 77 
CCK75896                 14 IALTTVVISMGIYALVQTY------------WLPDislfkVITISSivstllILFLLTSFISRKIWAVLAFFDE--SMFP 79 
PRJNA305460:AT984_08005  94 NLAGTWdcK----------------GETLDRDGKI-----TYAWTAEVTIIQCWDKLRVRLKTSQSGSNSMAAALTH--D 150
CCW33854                 80 NLNGEWklQ----------------GWTKWSRG--------QDYQGEAVIKQTWTRISICIETEQSSSKSITASLLV--N 133
WP_000530048             87 DISGEWscK----------------GISDYQEENSemikhNREWIGKVTILQSWDKVRIRLETEFSTSDSISAAIIY--D 148 Acin...
EPF71573                 90 NISGDWacN----------------GESSFE---------NLSWQAQVKITQTWDRIRIVLITGKSSSESVSAAIIY--D 142
CBH22627                 79 DFNGKYsiV----------------GMSFKNTTNE-----NFEWEGILSIKQDWDKILISMKSKNSSSESISVNGSVvyH 137
CCK75893                 77 NINGTWelT----------------GQTLNDDGTT-----KYDWEGCIGIEQSWKSILIHLKTKNSQSESYTATLSRrfG 135
WP_046350672             94 NLAGIWdcQ----------------GESLHLDGTV-----AYQWNGEVTIVQSWDKLRIRLKTAHSGSSSMAAALAT--D 150 Jant...
WP_009582362             76 NLAGDW--T----------------GEIKSNWNDKn----LDSIQTDVSIRQSFFHIQVKVKTGESKSYSIGASFDI--D 131 Fulv...
CDG17395                 78 DLNGKWdvTihwqkkkydkcenckkCDLCSKPE-------KDISEGECEIKQSLYNINMIIRTKSSNSKTLSVTPIR--S 148
CCK75896                 80 DLNGTWe------------------GEITLEDG--------KEISAKAVIRQSLLATQIDMHGETTKSITLETTPTI--E 131
PRJNA305460:AT984_08005 151 S-VDGWLLLYQYRNDP-RIGEPELNSHVGTCSATFSK------DLKSATAEYFN-GVGRATFGKMTWTR 210
CCW33854                134 E-DEGITLIYVYRNDPkANVPTTMHSHRGTAVLRLKD------DC--LEGEYYS-GRDRQNFGTLILRR 192
WP_000530048            149 E-IEEYKVLYSYENKPkDLDHEELRIHRGFVELTLHK------DNKSASAKYYN-VTGRRTMGTMLWEK 209 Acinetobacter
EPF71573                143 D-IKGYRLVYNYRNQPdSLDDESLKTHIGFVELKLDL------DKNQASGNYYN-VSGRKTFGNFIWTR 203
CBH22627                138 P-MKGYKLIYSYENTP-NNNVDELHKHNGTCEFSFEE------NLINATGNYYNdGKNRENFGSMELRR 198
CCK75893                136 P-TGGWMLSYSYRNEPeLEQSHELNSHKGYCEIEFDK------KLTVGKASYFN-SAGRRTFGVMNLKR 196
WP_046350672            151 S-VDGYVLLYQYRNDP-KVGESTLASHMGCAVVTIAN------DLTLATAEYFN-GGSRGTFGKMNWTK 210 Janthinobacteri...
WP_009582362            132 QdRGQQQLFYSYLNTPrPGVRERSEIHYGSTVLYFDGf-----NVTTMEGEYWT---SRETTGEITLKR 192 Fulvivirga imte...
CDG17395                149 SsLENITLYYIYQNEI-KNEIKEPLIYQGAAILEIKL------DSNTLEGNYFT---SRDTIGKFTLKR 207
CCK75896                132 --QGQKKLYYVYRSTP-KT--PGWPAYNGSTLFDIRTigsgkgKKYELSGHYYT---DRKTIGRIRLTQ 192
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap