Conserved Protein Domain Family
Helicase_PWI

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pfam18149: Helicase_PWI 
N-terminal helicase PWI domain
This domain is found in spliceosomal RNA helicase Brr2. Brr2 is required for the assembly of a catalytically active spliceosome on a messenger RNA precursor. The domain is found in the N-terminal region and is non-canonically PWI-like. The PWI-like domain is thought to be involved in protein-protein interactions.
Statistics
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PSSM-Id: 436309
Aligned: 29 rows
Threshold Bit Score: 112.698
Created: 19-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_013935858  157 DTEEFDIKSVDKYYLTRLLAQEFKd-lDSYRHTELSQSINELLTKFa---EEeldMRKLESSLLQLFDY--ESNDTVRKI 230 
XP_011275028  261 AHKALSIKDIDAFYLQRLVSSHHTd-lDASAVQSLSSGLLELIESSl---AG----KEFEQRLLQIVDS--EKVELVQLL 330 
XP_001642585  280 EKNKISIFTVDEFYVERLLLKELKs-iNTEMVPNLSSKILLAIEGSs---DS---DKEIEKKLLELLDF--DSLSLVNFI 350 
XP_003028668  272 DKDIVAPHEIDGFWVQRQISEAYP---DPVTAADKASAVISILGSE----SS---LRDCENQLMDLFEY--QSFHIITKF 339 
XP_047813572  295 GKHDLTIYDIDGFWLQRLIGSHFP---DPIEAESKTKEAINLLSADn---SS---LRDLENSLVDLFDY--DKFELVSVL 363 
5_pfamImport    1 SKDTVHPHEIHAHWLQKQIKEYFS---DSQEAEGKTLETKDILFSDi---DA----RECENQLMQAFDFdqEKFSLINRL 70  
3_pfamImport    1 KDKSIPAREIDAYWLQRQIGQNYA---DAHMQQVKTQQALQILSGLseegDEr-tLREIENDLMELFDY--EHHELVQKL 74  
Q6C0Y6        246 DSDVIPATEIDSFWLQREIASLVGg--DQQESIDLSRRVFDILAGE----SS---LRETENELSEAFDF--DHLDFVAKL 314  Yarrowia lipo...
XP_011126829  306 DKEFVPAHMIDAFWLQRTIGTVYA---DVHEAATKTTTAMDLLASEv----P---LRQLENDLMELFDY--EHFDTVKVL 373 
CCG83995      260 DKDKVNVSEIDSFWLQRKIASEYPshaDAHMTQEKADSAYALLSSPi----S---LGMLENDLMDLFEY--DKFQLVQIL 330  Taphrina defo...
XP_013935858  231 TKHPLEIYFAIKLSQ--ASE-AEKSQIFDTMVSKGLESWVNQY 270 
XP_011275028  331 ITNREAILWGIKLAK--ANP-EERQSILTALESSESKHLLEDL 370 
XP_001642585  351 IQNKYEILWGCKLSK--ANK-IDKEELIDTMIGNGLQYLVDEY 390 
XP_003028668  340 LKNRDVIFWCTKLMR--SDA-DERVNVEVAMREKGVGWILREL 379 
XP_047813572  364 TKHRDIIVWGTKWSR--SDE-DEKVNLAVVMREKGVGWIVKAL 403 
5_pfamImport   71 IKNRDVIVWCTKLSEvgGPQsQEYQNIASEMTELGLDWILKAI 113 
3_pfamImport   75 ISNRDKVVWLTRLAK--AEDdEARGVVEREIIAEGLRWILDEL 115 
Q6C0Y6        315 CHNRDRVVWITRLQR--ADG-PEKDTVKKQMTSLGLASLVSEL 354  Yarrowia lipolytica
XP_011126829  374 TKNREKIVWCTRLAK--AGEeDEAEGIKKEMIEAGLKGILDEV 414 
CCG83995      331 VKNRQSIVWCTKLAR--SSSsEETNRIRSDIQNQGLTELLREL 371  Taphrina deformans PYCC 5710
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