Conserved Protein Domain Family
HAD_SAK_2
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pfam18143: HAD_SAK_2 
HAD domain in Swiss Army Knife RNA repair proteins
Family of HAD domain phophoesterases observed in large eukaryotic proteins with predicted role in RNA repair, the so-called 'Swiss Army Knife' repair proteins. May be involved in phosphate group removal during RNA re-ligation.
Links
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Statistics
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PSSM-Id: 497027
Aligned: 76 rows
Threshold Bit Score: 73.1579
Created: 19-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
WP_066971160   4 IIFLDIDGVLQPTYSENrfdyvddenisklyknllkeksidysiydkydvaavyYDWnKeAVSELKRIIETTNAKIVISS 83  Methanobrevibac...
WP_014139847   5 LLYLDVDGVLNPVFPHPdddfdtht----------------------llgysvlLSP-R-HGDWLRELADRYE--IVWAT 58  Kitasatospora
WP_068209888   4 LILLDVDGVLNPSVRSDrgagg----------------------------hrleLAP-E-REALVHRLA-AIGS-VVWAT 51  Rathayibacter t...
WP_068251426   4 LILLDVDGVLNPSVRSDraags----------------------------hrleLEP-E-REALVARLA-AVGT-IVWAT 51  Rathayibacter t...
WP_056866494   4 LILLDVDGVLNPSVVSDraagg----------------------------hrlvLDA-D-RAALVARLA-AAGT-IVWAT 51  Rathayibacter s...
WP_056665997  10 LLFLDLDDVLCLNRPYGgrhlqltpr--------------------ppdlyqriWSV-P-AIEALQQVLREARPQVVLTT 67  Acidovorax sp. ...
WP_062616067   5 TLILDLDGVLITTPMWKadeida--------------------------dgyskFNA-N-CVTNLNKLLSVFECDIILSS 56  Flammeovirga sp...
WP_035128970   2 LILLDIDGVMLSASSWKpverld--------------------------dgfssFSP-R-AVSSLQRIISETGASIVLTT 53  Flavobacterium ...
WP_046368988   2 LIFLDIDGVMVPAKGWKvpelmd--------------------------dgfpaFSN-R-AVVALAQIIARKN-TIILTS 52  Flavihumibacter...
WP_056068741   2 LILLDIDGVMVPANSWRkpefld--------------------------dgfpvFSN-G-ATKALQKLISETSANILLTT 53  Flavobacterium ...

WP_066971160  84 DWRIFGDiQRLIDLFEIHNl--gKYIIDITPNWDYEESENIkkhyeeklinedgsigfitSRELEILEYMRNNNn--EIE 159 Methanobrevibac...
WP_014139847  59 TWEDKAN-LHIAPLLGLPElp-vVVFSGYVPQPGDPRVPLMe-----------------lFSATKWAPIL-RHAq---GR 115 Kitasatospora
WP_068209888  52 TWPPRLT-SVLTADLGLPRgtraIVFDGGLPHDPRFPGQT--------------------GKLQPVAAWLEAQr--ePVD 108 Rathayibacter t...
WP_068251426  52 TWPPRLT-SVLAEDLGLPGgteaIVFDGGLPRDPRFPGQT--------------------GKLQPVAAWLESAAergPID 110 Rathayibacter t...
WP_056866494  52 TWPPELT-SVLARDLRLPEgteaIVFRGGLPRDARFPGGT--------------------GKLQPVALWLDQARatgPID 110 Rathayibacter s...
WP_056665997  68 SWLSFLDlaaARQLFELTGla-qLSQA-LHPDGEAPQLRGQ-------------------TRLEAIDAWLRRHAw---TG 123 Acidovorax sp. ...
WP_062616067  57 TRRTVKKlDEFNEIFKYRQi--nCPIKSFLPIYDHCK-----------------------NRKEEIEQYINES----DIV 107 Flammeovirga sp...
WP_035128970  54 SHKSTYSlPQWRKIFKKRGi--dVSIVGKLEDNTTFL-----------------------TRKEEILNWQLKNk---SIN 105 Flavobacterium ...
WP_046368988  53 SHKANFSiQEWKSIFKRRGi--dIEKLQRLPASPLNV-----------------------SRKEELMKWFSSHp---MTG 104 Flavihumibacter...
WP_056068741  54 SHKSKYSiDKWREIFLLRGi--dVQSIDVLPENTLGL-----------------------NRREEIMKWIDIQk---VHS 105 Flavobacterium ...

WP_066971160 160 EYVAIDD--------LTIDKILKEHFVETSP--YLTKEDA 189 Methanobrevibacter filiformis
WP_014139847 116 PFAWVDDcipp-rlvRRSVLRADRLLVPVDPaqGLQREHV 154 Kitasatospora
WP_068209888 109 AVVWIDDnlredavaWAREQPLPFHLIRPESavGLTDDEV 148 Rathayibacter tanaceti
WP_068251426 111 AVVWIDDnlredaylWAREQSTPFHLIRPDSaaGLTDDEV 150 Rathayibacter tritici
WP_056866494 111 AVVWIDDnlredayaWAREQDTPFHLVRPESaeGLTADEV 150 Rathayibacter sp. Leaf296
WP_056665997 124 KYAIIDDllsg-tglRRSRHEKSGRLVLCEVdvGLSQVHV 162 Acidovorax sp. Leaf160
WP_062616067 108 DFLIIDDdk----slNSLNPSIQNKLVRTELikGFNEEKL 143 Flammeovirga sp. SJP92
WP_035128970 106 DYVILDDdk----slNGLPSNIKEKLVLTSPmlGLTNDDA 141 Flavobacterium aquatile
WP_046368988 105 DFVIIDDds----slNELPVEYKRALVQTSPtvGLTEEHV 140 Flavihumibacter petaseus
WP_056068741 106 HYIIIDDdk----slNALPGFVKANLLQTSGsiGLTEYQV 141 Flavobacterium sp. Leaf359
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