Conserved Protein Domain Family
SLATT_fungal
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pfam18142: SLATT_fungal (This model is not part of the current CDD release)
SMODS and SLOG-associating 2TM effector domain
The SLATT domain contains two transmembrane helices. SLATT domains are generally predicted to function in bacteria as pore-forming effectors in a class of conflict systems which are reliant on the production of second messenger nucleotide or nucleotide derivatives. SLATT domains are predicted to initiate cell suicide responses upon their activation. The role of this fungal family is not yet understood, although the expansion of the family in many fungal lineages points to a potential role in conflict.
Links
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Statistics
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PSSM-Id: 523145
Aligned: 122 rows
Threshold Bit Score: 39.7813
Created: 19-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
KZT34312      12 AAYEEEANYTYYAEVASKLLTVALTLQVIINALVTALSAIVSARrsQIMTTILGGLGTLISSYLAKARGAGEPELSRNRA 91 
XP_029757166 129 RCLAQDQKNRVMYGLSNYVITFLYLLQILIAAAITGLSA-TQTG--ETALTVLGAINTVLAGVLAWLNGQGMPTRFRRAR 205
XP_007931369  77 RAKDEERRSRIAYILTSYISNFLFMLQILLAATFTALSAYKDSN--AVTLTVLGALNTVVAGSLAWQKGQGVPQRYRKAM 154
XP_016630890  84 RARQEERASRIAYLCTSIISNTLYMFQILLAATFTALSAYKDSR--RVTLTVLGALNTVLAGCLAWQKGQGVPQRYRKAQ 161
XP_003003917  96 SILREHAIKKWQRRILTATIYACHIAQIIIGAVLTALGPSSAIH--AVSITILGATNTTVAGIMALVKGQGLMQKLKNEE 173
Q7RZ81       204 ATMKAQREKRIKHALIDVLLYASHLAQILIGATLTALGPSAGKH--AILITVLGAVNTVIAGVLALIKGQGLPERLRHDQ 281 Neurospora crassa
KKY39874     126 HVIEQRRRKKLLHHTLGIILYISHFIQIIVAAVLTALGPNAKDY--EVPITVLGGVNTVIAGVLALLKGSGVIERLSKDE 203
EMR70278     114 NVITIRNRKRMRYSGVGAFIYTCYFTQIVVGAALTALGASPDQA--KWIITVLGALNTVLAGVLAMIKGLGQPQKLGRDH 191
XP_007842102 118 MVIDAQVKKHIQHDFMTALMYFFYLAQIVIGAALTALGPSAPQY--TLPITLLGAFNTIIAGVLALIKGSGQPQRLSKDQ 195
XP_013328022  98 AVLREQRAKARLFWAVNLTVYFCHFAQIIIGASLTALGPTSTRH--TRAITVLGAANTVIAGVLALINGQGLPHRLRKDE 175

KZT34312      92 RELQKFIRTVEG-----FLVDY-----GhEkiirtsdpdeleidnarqtlqntgaVVepapQdPearrrialeKHIKEFR 161
XP_029757166 206 DQYREVVKAIEAaertfAEINYre-weG-D-------------------------SR----P-Dp-------fAVRDRLE 246
XP_007931369 155 DQYQALLLEIEMtersfVDMDSsn--nS-A-------------------------GA----L-Dp-------iVEMARLQ 194
XP_016630890 162 DQYQALILEIEMaersfLDLEYngdqgG-G-------------------------VK----L-Dp-------rTEKDRLQ 203
XP_003003917 174 LELMQVKGWVEEt---eALMEA-----G-I-------------------------VG----G-Dree----vsRLVAEGY 210
Q7RZ81       282 AEFRKLQDWIEQt---eALLAV-----G-V-------------------------IG----R-Drke----vgLLIQVAF 318 Neurospora crassa
KKY39874     204 VEFAKLKDWIEEt---eAMISV-----G-I-------------------------LG----R-Srke----vgILVEQAF 240
EMR70278     192 MEYRRLQDWIEEt---eALLVV-----G-I-------------------------IG----R-Nrre----vgSLVESAF 228
XP_007842102 196 MGYRKLQDWIEEt---eALLSV-----G-V-------------------------IG----R-Dkke----vgMLVEVAF 232
XP_013328022 176 IEFRKIQDWIEEt---eALLAA-----G-I-------------------------IG----R-Drte----vgLLVETAF 212

KZT34312     162 RQFEAIEGK 170
XP_029757166 247 QLYEDARAD 255
XP_007931369 195 KLFDTAKAD 203
XP_016630890 204 KLFDTAKAD 212
XP_003003917 211 RRYRAVMTE 219
Q7RZ81       319 EKYNAVRQS 327 Neurospora crassa
KKY39874     241 RKYNACFGQ 249
EMR70278     229 KRYNAAKAS 237
XP_007842102 233 KRYNAAKAS 241
XP_013328022 213 KKYNAAKAS 221
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