Conserved Protein Domain Family
AGS_C
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pfam18134: AGS_C 
Adenylyl/Guanylyl and SMODS C-terminal sensor domain
This entry represents a sensor domain found in cytidylate cyclase (PycC, clade E) and cyclic GMP-AMP synthase (CdnB) from E.coli, which are involved in immunity against bacteriophage. PycC and CdnB are part of the Pycsar (pyrimidine cyclase system for antiphage resistance) and CBASS respectively, which are closely related; both of these proteins synthesise cyclic nucleotides in response to infection which serve as specific second messenger signals that activate the adjacent effectors. This domain (AGS-C) adopts an Ig-like fold and it has been suggested to mediate phage detection.
Links
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Statistics
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PSSM-Id: 497018
Aligned: 47 rows
Threshold Bit Score: 83.8127
Created: 19-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
EDY87677     292 LAYRKSLEfsALprsFrQqIDgs----------nvIDHAaISYKC--FTVED---DVKSEYISASSFLEKHVSLVFVvts 356
WP_038642625 315 QSLPSHCE--RLr--W-P-MA--------------TSPQkLNVKA--VLQKDk-sSVSIGDLAAYNTIPKHHWIRFNv-- 369 Pseudoalteromon...
WP_012934292 301 GDYSHAQT--PSdrgW---AErs-----------dARYA-VEITA--STQRGkrgQTRRPYSSGGPVVFAGHKLRFKa-- 359 Conexibacter wo...
WP_013834156 346 SHPDHQEP--AA---W-PiSA--------------RPWIdLLITA--HHQRKr--SSAGKAVQSGEVLAPRGGLLFRafa 401 Novosphingobium...
WP_011971344 373 EAIPHRQK--PN---WnV-----------------YSWVdIYIKAt-KTKSGf---SFPKQFNSGDFLTKNVDLKFEaka 426 Alkaliphilus me...
WP_015831104 304 SEAFSFLM--PL-----PeTDqveiveeisgravmPLPE-IEIQV--FAGNPs--RLVMTHRNEVPSVSKGCSLSFKi-- 369 Methylovorus gl...
WP_027447722 277 FDWEKYLN--SFs--FlPkTKdfn---------nyISPTdFEVVCy-VKKNDs--DQYTRYFQSSSSLDKGMKVMFEl-- 338 Pontibacillus m...
WP_036786998 277 FKWETYLKtfNS---YyNdSKls-----------fSAPDdFEIICkyGEENG----PVNDYKQNSYAIKKELYAGFQlvl 338 Pontibacillus c...
WP_050350046 277 FNWEKYLDsfSS---L-PkSKseg--------riySSPTdFELICs-VKKEEd--EPFKKYCQNSYSLEKGMHLRFEl-- 339 Virgibacillus p...
WP_081905445 309 LKFREFVRllPIpleMrQkIVng-----------vLAYPgIQFQA--FCRDM---QSYNEYRSVSRCVNKGTEVKFQi-f 371 Janthinobacteri...

EDY87677     357 NTRyRIN---YPLKVVFIKTNHGIDTPedeR-DIEQKGKVrYLkktkisAYNKApvpfaRTeleENTLYRGLHTMKCEIY 432
WP_038642625 370 KDTlDHQ-----TSIFWQVVNTGSEAA---N-DDCLRGK--FF------QGSTI-----HK---ESTLYRGTHWVEAVAV 424 Pseudoalteromon...
WP_012934292 360 --EiSAP---NHVDVWWQVANTGAHA----RnASGLRGEI-FRard-srRGTNSdq-teNW---ENTAYTGSHLVRALLV 424 Conexibacter wo...
WP_013834156 402 FGGqSFP---SDCHIKWRITNTGITAM---I-AKCGRGD--FYs----sEKGNT-----RW---EPLAYHGVHVAEAFLI 460 Novosphingobium...
WP_011971344 427 ENI-------KQYEVHWQVTNTGTEAK---S-SNCLRGD--FYdgq-ivEGKRI-----RK---ESTSYVGTHIIECYLV 484 Alkaliphilus me...
WP_015831104 370 VNPhVVP---EFATVEWTVRNEGQEAD---Q-KSDLGHRR-VG------MRLLD-----AE---EHTAYYGRHFMDCIVR 427 Methylovorus gl...
WP_027447722 339 FNYaNMP---IG-NIKWRVVNYGDEAE---QsEKDLEYYMkDF------EGEYF-----CE---QSTAYTGLHFMECYIY 397 Pontibacillus m...
WP_036786998 339 KGNlKFI---KPSKIKWKVINRGYEAT---K-ANVLEYYVdEY------EDQYT-----CY---RPIGFNVHHLMECRLY 397 Pontibacillus c...
WP_050350046 340 LNYaSMP---IG-NIKWKVINYGTEAE---QsESGLEYFMeQS------EGEYV-----CE---QSTAYTGLHFMECYIY 398 Virgibacillus p...
WP_081905445 372 IEPhALDglrMPLRGEWIRKNHGQQAAdanM-SHDDRGDFeIKpnaanrGRDPR-----KYswtRHAEYRGIHTMEIRIY 445 Janthinobacteri...

EDY87677     433 dA-NEHLLFR-DWIGVMIK 449
WP_038642625 425 -R-QGVCIARsGPIVVKIA 441 Pseudoalteromonas piratica
WP_012934292 425 -R-NNEVVATsAWFVVNIY 441 Conexibacter woesei
WP_013834156 461 -SaDGALLGQsRPFHVVID 478 Novosphingobium sp. PP1Y
WP_011971344 485 -K-NGVCHGKsKPFIVNIR 501 Alkaliphilus metalliredigens
WP_015831104 428 -M-NGQIYAV-RRIPVNVR 443 Methylovorus glucosotrophus
WP_027447722 398 nP-ESKLIAK-DRSGIYIN 414 Pontibacillus marinus
WP_036786998 398 nS-HGSLIGR-SQFGIYVN 414 Pontibacillus chungwhensis
WP_050350046 399 nH-GGNLIAK-DKFGIFIN 415 Virgibacillus pantothenticus
WP_081905445 446 dV-NNKLLFS-DIIGIHIR 462 Janthinobacterium agaricidamnosum
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