Conserved Protein Domain Family
PRC2_HTH_1

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pfam18118: PRC2_HTH_1 
Polycomb repressive complex 2 tri-helical domain
This domain can be found in the Polycomb repressive complex 2 (PRC2) present in Homo sapiens. Polycomb complexes maintain repressive chromatin states by silencing gene expression. PRC2 does this by methylating lysine 27 of histone H3. This domain makes up part of the N-lobe which is involved in regulation.
Statistics
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PSSM-Id: 497005
Aligned: 11 rows
Threshold Bit Score: 120.959
Created: 19-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
KFB43971      153 HGDK-EGSFIDDAMFVELVHALMVVTAKDA-------ADEPDGKKLHSRAsssgetidtskadeslrksklKk----tEK 220 
XP_002047854  147 HGDK-DPSFMDDAIFVELVHALMRSHSKEL-------EETVTSPSAKTETpta---------------pklK------EE 197 
KZC13636      148 HGDR-ESGFMDDSIFVDLVNALAQYEKDDK-------EREHTKKGKEKEE---------------------DkdkrdsSS 198 
XP_032780107  361 HGDR-EGGVIDDDIFVELVTALVPYCEEDE-------RSEPPSSLKADKA---------------------EkpdegaRC 411 
EEC12589      154 HGDR-DAGSVNDELFLELVHALMTYEDEPG-------TTNRTLTEANYYD---------------------Icwf----r 200 
KOF99173      220 HGDR-DTKFINDDLFMELVDALWANYNDTD-------PEQRELSSPSSQN---------------------TndgiktE- 269 
XP_009048483  179 HGER-PSNFMSDDIYIELVNNLHANYPDID-------DNGFKIIAYMAKL---------------------Nf----lD- 224 
KFO97549      145 HGEE-GSVLISDAVFLELVNALNQYSDEEE-------EGHNDSEVKQEDG---------------------KeelpvtKK 195 
3_pfamImport    1 HGDR-EGGFISDEIFKELVDALSQYSDHEE-------DEEEEASAGTVGDmt------------------gKkeeervMR 54  
1_pfamImport    1 HGDR-EGDFINDELFLELVTSLNQFHMQSSdlvliegTSKSGQHEER--Snkflcfcsv----ilnfyhyqKnkessaDE 73  
2_pfamImport    1 HGDRgETLFFNGVIFTDLKAGLTQRSDADS-------SSAGHDANGLCQH---------------------KrsirpsRP 52  
KFB43971      221 --NNESEtngdgter-------------ddgrqiehSTDGGNDLPSAKAFPAPIIFQAISSQFPEQGSAEELRDKYIELT 285 
XP_002047854  198 --DEKTEtttsseptaaasssatedkeavpvaviadTKCKVEKVKEKLPFPAPIIFQAISANFPDKGTPQELKEKYIELT 275 
KZC13636      199 ikAEVKS-----------------------------EKSSEDVKTEVNPFPTMHIFNAISSMFPDKGRPEELKEKYIELT 249 
XP_032780107  412 --DAVTVtk--------------------------eKPAGTSGSTSAKDLPNIIVFQAIASVFPDKGTPEELRERYMELT 463 
EEC12589      201 tlARRPL-----------------------------RNLFPEKCEEKAPSPSDFIFAAICSVFPDKRTPEELKERYRELM 251 
KOF99173      270 -------------------------------------LKEDEVDKSRKTPPADIIFQSISAMFPDKGTQEELKEKYIDLM 312 
XP_009048483  225 --------------------------------------DDDDKSFPKPTAVRDIIFKSISEVFPEKGNPEELREKYRELN 266 
KFO97549      196 --RKR-------------------------------IAVEGNKKCSKKRFPNDMIFTAISSMFPEYGFPEDMKERYRELT 242 
3_pfamImport   55 --RSSLE-----------------------------GSEENKDVSSSKKIPNDKIFTAIASMFPYKGTTEELKEKYKDLL 103 
1_pfamImport   74 --DGEDD-----------------------------NKIGDENNDAISTFPCDKIFSAIADLFPDKGSIDDLKEKYKELT 122 
2_pfamImport   53 --C--------------------------------------KESQAPRKFPSDKIFEAISSMFPDKGTAEELKEKYKELT 92  
KFB43971      286 E 286 
XP_002047854  276 E 276 
KZC13636      250 E 250 
XP_032780107  464 E 464 
EEC12589      252 E 252 
KOF99173      313 E 313 
XP_009048483  267 E 267 
KFO97549      243 E 243 
3_pfamImport  104 E 104 
1_pfamImport  123 E 123 
2_pfamImport   93 E 93  
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