Conserved Protein Domain Family
SNX17_FERM_C
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pfam18116: SNX17_FERM_C 
Sorting Nexin 17 FERM C-terminal domain
This is the C-terminal domain of sorting nexin 17 (SNX17) present in Homo sapiens. SNX17 localizes to early endosomes where it directly binds NPX(Y/F) motifs in the target receptors to mediate their rates of endocytic internalization, recycling, or degradation. The domain is known as terminal band 4.1/ezrin/radixin/moesin (FERM) domain. The FERM domain binds directly to the common motif, NPX(Y/F), in the cytoplasmic region of its target proteins.
Links
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Statistics
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PSSM-Id: 436285
Aligned: 10 rows
Threshold Bit Score: 132.536
Created: 19-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
KFB47492     268 GCLQFPRASVDYPEPNTVATVVLGNKE-LNL-LTFDGK-EMQEIKFKVTRIRCWRVTPIhINdehsSMEPQTsqqskISL 344
Q28HD5       268 GYLHITSCTSDYPECDSEVTIWVGNNE-MSChFYSPGG-HAENLRLSIKDLICWNVTLL-PKkq-eVMSPNH-----QHL 338 tropical clawed...
PNJ43976     270 GYLQLDPCTCDYPEPGSGAVLSVGNNE-ISCcITLPDS-QTQDIVFQMSRVKCWQVTFLgTPl--dTDGPQTtl--nqNL 343
XP_069050945 230 GHIQLDPCTCDHPEPSCPAAVWVGHPG-LHCcITLPGN-QTREEHFEINRMKSWCVSMLsRS-------SQDd---aVGL 297
EFN80289     268 GYIQFAPCFCDYPQHGSRVLLAIGRNE-LNLrILSSE--EEHEVAFKVSRMRCWRITTMqNG----MEHCEDn---eCSL 337
1_pfamImport   1 GCIQFKPCISDFPENKSRVIISAGNYE-IKYkILTSEK-EVKEAAFSVTRIKCWKVKQLlVVi--ySLSDDAtq-ptDEA 75 
VDM98057     294 GYEVLMPCISDYPRHRTECSLKVGRRH-ILLeFKNDEN-KISRAEFRATRIRVWRISQQdNg----------------DF 355
XP_002117154 266 GYIVFEMCTCDYPKENTKVLVSIGDMA-LNIkVFLEEG-KVKAGSFKLTRMKCWKTVAKrE-----ENSDe------YLF 332
XP_004995556 264 GYAFFGEVKCNWPENDSMVTVSLGSVPpAPAcMRLHDKvSGEDRDFLVRRMRCWRTYSTeD-----------------GV 326
XP_004364463 275 GYIELDPCVCSHPAPDSRVIVAIGSND-LRVrLVG-QK-RSEAATFRVRRTRCWKLSAHdK-----------------VV 334

KFB47492     345 ELSFEYLMAkN-----QLKWITIYSEQSMLMSVCLQSIVDELL 382
Q28HD5       339 ELKFDYQQG-S-----SLKCITIHTEQAFLLSSCLKKMLSERP 375 tropical clawed frog
PNJ43976     344 ELRFQYSED-S-----CWQWFVIYTKQAFLLSSCLKKMISEKM 380
XP_069050945 298 SLSFEYTFD-D-----VWKSITLHTKQAFLLSRLMLLVLKEQQ 334
EFN80289     338 ELSFEYLVArN-----ELQWITIASEQAILMSVCLQAMIDELL 375
1_pfamImport  76 ILQFEYLFSkD-----NLKWITIQSEQAIMLSMCIKSMVDELI 113
VDM98057     356 MFLFEYLMSsG-----EFQWIALRTNQAILLSLLLQSIGFEIL 393
XP_002117154 333 ILSFEYLMSkE-----KLQWISIASSQAIFMSMCLKDMAQEHV 370
XP_004995556 327 ELEFEYLVStDdngdmKMKWIKLVSEATIHLAMCLQFLVEEML 369
XP_004364463 335 DFAFDYLFGpN-----ELRWVTMAGPQTIYMSMCVQSVVDELL 372
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