2FHD,3QII


Conserved Protein Domain Family
Tudor_3
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pfam18115: Tudor_3 (This model is not part of the current CDD release)
DNA repair protein Crb2 Tudor domain
This is the tudor domain found in DNA repair protein crb2. Structural and functional studies of Crb2 and its mammalian homologue 53BP1 indicate that the conserved tandem-Tudor domain of 53BP1 and Crb2 preferentially interacts with H4K20me2, though it also binds to H4K20me1. Furthermore, despite low amino acid sequence similarity, Crb2 is structurally related to 53BP1 in having two tudor domains and a conserved dimethyllysine-binding pocket, and that, like 53BP1, it directly binds H4-K20me2.
Links
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Statistics
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PSSM-Id: 523131
Aligned: 55 rows
Threshold Bit Score: 56.0138
Created: 19-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
2FHD_A         10 NRVLAFFKGYPSFYYPATLVAPVHSavtSSi-XYKVQFDDATXSTVNSNQIKRF 62   fission yeast
XP_018034990 1072 DRVFAHWPS--IGYCPATCVGRVDS---H---RLRVRFDDGTHHDLESMQIRAL 1117
XP_038794695 1092 NRVFASWPG--SHFYPATCLGRSDS---K---QLQIRFDDGNTTSLDAFQVRPL 1137
Q0UAQ8       1067 NRILASWPG--SHFYPAICLGRVAG---R---QLNVRFDDGNTTTLDASQVRAF 1112 Parastagonospora nodorum SN15
7_pfamImport    3 NRVFASWPG--SHFYPATCLGRVAG---Q---QLRIRFDEDNITNLDAFQVRAL 48  
XP_003845006 1085 NRVFASWPG--SHYYPATCIGRTAS---R---QLRIRYDDGNTTAMDAMHVRSL 1130
EFQ89105     1055 NRVFASWPG--SHYYPATCVGRATS---R---QLQIRYDDGNITSIDAIYIRAL 1100
5_pfamImport    3 ERVFALFKGTRQNYYPATYLGGSAD---GM--AYKIKFDDGTSTNVDTQHVRRL 51  
XP_002838100  926 ERVFALFKDVKMCYHPATVLSTDSK---G---FIKVVFDDG-TEDVLDKEVRSL 972 
1_pfamImport    3 NRVFALFNGSVNGYYPATCLSITRT---GVslRYNVRFDDGTCTSLERHHVCAM 53
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