2MJ6


Conserved Protein Domain Family
DraK_HK_N
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pfam18092: DraK_HK_N (This model is not part of the current CDD release)
DraK Histidine Kinase N-terminal domain
This is the N-terminal domain found in DraK Histidine Kinase (HK) present in Streptomyces coelicolor. Activation of the DraK HK leads to autophosphorylation of its kinase domain in the cytoplasm and subsequent transphosphorylation of DraR promoting blue-pigmented polyketide actinorhodin (ACT) production. The N-terminal domain is known as the sensor (or input) domain and undergoes a conformational change resulting in phosphorylation of a conserved histidine in its cytoplasmic kinase domain.
Links
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Statistics
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PSSM-Id: 523115
Aligned: 70 rows
Threshold Bit Score: 54.1677
Created: 19-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
2MJ6_A         5 RTISSTAQERVDLEAVRLASIVDSRLIGT--GSVDEDFLREQIRDAR------YAVIRIPGQpVVEVGtKP-TGDVLQGR 75  Streptomyces co...
WP_043607608  30 QLVRDGELRDRDNRAAALARQVETRLSTE--RPITDELLEYYVGGDDgsl-aaSVSVVTADGeRFRAG-EPvEGRAYPQV 105 Cellulomonas ca...
WP_034227822  30 QLVRDGELRDLEQRAVNLARGVENRLVAD--REISEDLLEFYVGGDErgslpaSVSVVTPAGeRFRAG-EPiEGRAYPEV 106 Actinotalea fer...
WP_034634214  30 QLVGETQLQAIQKRADELADKADFRIDES--IPFSERMLERHIGGDGel--paFVLVTAPDGtRYQAG-EFiEGRTLSKH 104 Cellulomonas ce...
WP_062103019  30 QLVRENEVRGLDVRAESVARTVDFRVERD--IALSNRMLEPYTGGDGei--saTVVVRTADGeTFRAG-PTvDERRLTVQ 104 Cellulomonas sp...
5_pfamImport   1 QLVRENEMRQLETRLQATARAVDFRADTG--VMLTDRMLEPQATAEGei--paQIVVRTNDGqVYEAG-EPiEGRSLSLT 75 
WP_013883103  30 QLVRENEVQRLETRAATAARAADFRVEQG--LELNDRMFEPYADADDdel-aaSVVVLMPDGtVYQAG-DRvQGRSLSVQ 105 Cellulomonas gi...
WP_056645943  30 QFVLANEMDQLQGRVDTLARNIDNRLAQN--EPIPQSVLDNASVgrpg-elpaYVFVNLPDGeQMTAG-EVvTGRANEAA 105 Oerskovia
WP_012879354  30 RYVIDTEAQRLSDRLDRLISSV--QVAQDaeRPVSDVALQRAVQGREgdi-kaFVSVTLPDGtLFEAG-DRvEGPVMEVG 105 Xylanimonas cel...
WP_068204230  30 QYVVAIEEQRVSDRVDSFVRTLERTVERG--ERPTDDQLARASEgrqg-dlpaLVTVSMPDGeLLTYG-SEpRQPSIVKA 105 Isoptericola do...

2MJ6_A        76 ATGEEGETVLVEEP 89  Streptomyces coelicolor A3(2)
WP_043607608 106 VRTDSGAVVLLSLS 119 Cellulomonas carbonis
WP_034227822 107 EYTESGAVVLLSLS 120 Actinotalea ferrariae
WP_034634214 105 VLSDTGVQVSIYVS 118 Cellulomonas cellasea
WP_062103019 105 TTSDTAATVLLYVS 118 Cellulomonas sp. B6
5_pfamImport  76 TTSQSTAVVVLTVS 89 
WP_013883103 106 ELSDTGATVVLYVS 119 Cellulomonas gilvus
WP_056645943 106 DRTDQNATVALSTS 119 Oerskovia
WP_012879354 106 GQTDSLASVTLTAS 119 Xylanimonas cellulosilytica
WP_068204230 106 AETDNRAWVSFEVS 119 Isoptericola dokdonensis
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