Conserved Protein Domain Family
E3_UbLigase_RBR
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pfam18091: E3_UbLigase_RBR 
E3 Ubiquitin Ligase RBR C-terminal domain
This is the C-terminal domain of HOIP present in Homo sapiens. HOIP synthesize the linear ubiquitin chains that help control innate immunity and inflammation. This region has an RBR domain which catalyzes the transfer of ubiquitin onto a substrate.
Links
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Statistics
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PSSM-Id: 496982
Aligned: 7 rows
Threshold Bit Score: 132.145
Created: 19-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_029686746  552 SRLHLLLQHYRVsptCLEASEGSSPAscctgT----CSVLELRDD-S-SRQEEACGRAALPGHRGYCEVHYKERLVELVN 625 
2_pfamImport    1 AQLQQLLKDNGI---GYDTEGPAGER-----K----CKVQLQKETpT-GVVDAVCNSDVVEGHAGLCRIHYIEYLVRKIR 67  
1_pfamImport    1 TQLQTLLKEHNI---SFDTELPPNLKtqeqnGeklkCLVQLQRETpA-GVIDTVCKEDIAEGQAGLCRLHYIEYLVGLIA 76  
4_pfamImport    1 KRLQQLLRNYNI---PYSLENRAEDKrsstgM----CTVLEHKETsD-GVVEEQCGRRAPVLYSGYCKLHYKEYLVELIN 72  
XP_014786196 1148 QELQKLLQMSHV---NFDTESKEQVd-----V----CPVIEQKEIsSdTFKDAKCGKCVSPNNAGFCTDHYKEYLITLIN 1215
XP_007565109  985 DRLQALLQRSGV---AFNTDPSNEtp---tdA----CGVMEQKDEgG-QPADSPCGLQTQPGQAGLCMKHYREYLVSLIN 1053
XP_009860551 1199 ERLQKILQDGGI---PHRTECTis-----nnT----CQVMEQQETpD-GLIDACCGGEVHENNADLCEVHYKEYLVILIN 1265 vase tunicate

XP_029686746  626 HFGCDPVILFSPAEMRAELQR 646 
2_pfamImport   68 ETQLEPLPLLNIDDLETCVKR 88  
1_pfamImport   77 RHKVDPISIFDLTDVQQELRR 97  
4_pfamImport   73 NHSLDPAVMFTIDEIATELQR 93  
XP_014786196 1216 ENKVDPIELFTKQNIIQVLSR 1236
XP_007565109 1054 DHSLDPAVLYETQELVVACQR 1074
XP_009860551 1266 KNHLDPATVFTGDELETCLHR 1286 vase tunicate
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