Conserved Protein Domain Family
PutA_N
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pfam18083: PutA_N 
Proline utilization A N-terminal domain
This domain is found in Proline utilization A (PutA) proteins present in Geobacter sulfurreducens. PutA are bifunctional peripheral membrane flavoenzymes that catalyze the oxidation of l-proline to l-glutamate and couple the oxidation of imported proline imported to the reduction of membrane-associated quinones. This domain is located at the N-terminus and is referred to as the alpha domain. The hydrocarbon tail of Zwittergent 3-12 binds to an exposed hydrophobic patch of the alpha domain which contains aromatic and nonpolar residues. The domain may be involved in membrane association.
Links
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Statistics
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PSSM-Id: 436258
Aligned: 11 rows
Threshold Bit Score: 103.59
Created: 19-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
WP_015168882               18 EAKTQEIARKILAASKGGfWDKLKGEMRLDDKLMAWGMGNEGLRVQLFRLIDCLPALKSKAEIARHMQEYLASDAVEVPA 97   S...
KGO34702                    7 DKKITARSSEFFASISGE-APSIFNKGWWTGKVMDWSMKNENFKVQLFRFVDVLPYLTTSESLARHIREYFAGDDQDVPA 85  
WP_041974453                7 DERIIAHGKRLYSAVRDE-RPSLFDSGTWAGKVMEWAMKDERFKTQLFRFVDVFPALRSGDQLTGHIREYFGGEQ-QLPQ 84   G...
PRJNA283178:NITMOv2_2067   24 EPAILRIGQQLAQLSAGL-SPTLFDGRWWSQSAIHLAMKDPVFKARLFHFIDALPAVADDARVVSLAEEYFGDLGHD-LF 101 
WP_006474067               13 EARIRQHGDALLQAAEAF-EPHNPV-SHWLQSLLSRLHQNPDFRIRALRFVDLLPALQEDAEVVRLFDEYFSDAQ-EFPL 89   e...
Q7NGY2                     18 ESETQRIGQSLLAAPQQS-RFSFFERSFWDEKLLEWAMADDELRVQLFRFIDCLPALKTNREVASHLQEYLGSVK--LPG 94   G...
WP_012934634                7 ESELRRVGGQLAAAFPSP-TRHPL--RTLDARALERTTEDVQLRAALLRFVDVVPACRSPDDVARHLTSFLDAVG-EPPQ 82   C...
jgi:Psta_0870              42 EARTQAIGRELFAGLGDV-RPKFWQRRWWDEKLMSWSMSDEQLKVQLFRFVDVLPMLTTADSVTTHLAEYLEPVQDRLPQ 120 
WP_013628950               14 ESETQRIGRSVWNQLSHQ-RPTLFDRRWLDDRIMSWAMADESIKVQMFRFVDVLPMLRDHEAINRHLHEYFEDVQESLPW 92   R...
WP_082838661                6 DERTKQYGREIFARLDRQ-GPVLFTRAWLEDKLMGLGMHDPALKVQLFRFVDTLPYLKQPAEVSRHLREYLNEAKDELPW 84   G...
WP_015249813               16 ERRAREIGRVLFAKVGG--GPKPWERGWWDDRMMNLTLGDPLVKVQLFRFIDAMPVLKTPAAIRRHLAEYLDEAGDRVPW 93   S...

WP_015168882               98 LRSLLNFSTDNpNSLTATAAATALGAAVESLARRY 132  Synechococcus sp. PCC 7502
KGO34702                   86 VMKWGAIGTGFgGKLTGVLVNRTIRSNLEAMAKQF 120 
WP_041974453               85 VFTAGVKAAGMlGSLGGSMLGKALGANIRSMARQF 119  Geobacter sp. OR-1
PRJNA283178:NITMOv2_2067  102 GLQWGLRALAA-TGIGARLTGKSIRKQVEQMARTF 135 
WP_006474067               90 PRLGRLAIRSG-RLLGPHQLAAAIRKAIGLLSRQF 123  endosymbiont of Tevnia jerichonana
Q7NGY2                     95 PLAKALDFADP-GSPAAAVATLGLRQGISQMARRF 128  Gloeobacter violaceus
WP_012934634               83 PLGIAMRMGA--TRAGRAALGAAAAHGVRHVAHRF 115  Conexibacter woesei
jgi:Psta_0870             121 AARVALGMARR-MPPLRAAVAKAARLSAMDFARRF 154 
WP_013628950               93 AARLALHVTDG-NRVLGRALAVNARSNARRMAERF 126  Rubinisphaera brasiliensis
WP_082838661               85 WVRWGTRLIPN-RGVLGQGLAFASQRGAEQMARKF 118  Gemmata sp. SH-PL17
WP_015249813               94 WLRLAVALAPA-GTLGERALAGMARFGATHMAHRF 127  Singulisphaera acidiphila
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