5T0H,7QVG


Conserved Protein Domain Family
RPN1_C
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pfam18051: RPN1_C (This model is not part of the current CDD release)
26S proteasome non-ATPase regulatory subunit RPN1 C-terminal
This is the C-terminal domain found in RPN1 proteins (26S proteasome non-ATPase regulatory subunit 2). The 26S proteasome holocomplex consists of a 28-subunit barrel-shaped core particle (CP) in the center capped at the top and bottom by 19-subunit regulatory particles (RPs). The CP forms the catalytic chamber and the RP is formed from two subcomplexes known as the lid and the base. The lid comprises nine Rpn subunits in yeast (Rpn3/5/6/7/8/9/11/12/15) and the base comprises three Rpn subunits (Rpn1/2/13) and six ATPases (Rpt1-6).
Links
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Statistics
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PSSM-Id: 523096
Aligned: 38 rows
Threshold Bit Score: 82.6847
Created: 19-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
5T0H_f        694 VGQAGKPKTITGFQTHTTPVLLAHGERAELATEEFLPVTPILEGFVILRKNPNY 747  human
XP_014567138  936 VGQPGKPKSITGFQTHTTPVRLANTERAEMATEEWFPYTHVLEGFVILKKNEGY 989 
GAC76110      899 VGQAGKPRTISGFQTHTTPVRVGTYERAELGSEEYLSYAHVLEGFSILLKNPGY 952 
CCA71827      851 VGQAGKPRTISGFQTHQSPVRLGYGDRAELGTEEYLSFASVLEGLVILTKNPGY 904 
KIK44207      895 VGQAGKPRTISGFQTHQTPVRLGTTERAELATEEFIPYAHVLEGFVILQKNPGW 948 
EPZ36164      857 VGQAGKPKTITGFQTHTTPVLLAHTERAELATEEFISLSHVLEGFVIIKKNPNF 910 
XP_005841652  823 VGQAGKPKSITGFATHTTPVLLAYEQRAELATDQYLPLTSVLEGFVILKENPDW 876 
XP_005773646  657 VGLAGRPKTITGFQTHTTPVLLAIGERAELATDEYLPLTSVLEGVVILKKNPEF 710 
KOX70760      786 VGKAGNPKSISGGYVHTTPTLLSSGERAELALDEYEALSSVLEGFVILREKSNV 839 
XP_002181371  857 VGQAGKPKRITGFQTHTTPVLLAATDLAELGTEEVFSMSSVLEGIVILKDNPDY 910
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