4Q2C


Conserved Protein Domain Family
Cas3_HD
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pfam18019: Cas3_HD (This model is not part of the current CDD release)
Cas3, HD domain
This HD domain is found at the N-terminus of Cas3 enzymes fused to a helicase domain. This domain is sometimes found as a separate protein. It acts as a nuclease that cleaves ssDNA.
Links
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Statistics
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PSSM-Id: 523083
Aligned: 128 rows
Threshold Bit Score: 111.773
Created: 19-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
4Q2C_A        40 WAKWGSGPDLG-----WHPLLCHXLDVAAVTLQXWRRVLPAawkarISGVLg---------VGQEDAERWLAFFAGGHDI 105  Thermobaculum ...
WP_076605316   6 WGKFDASAGT------RHHLAHHCADVAAIFRRLV-----------MLPAFsarleqaagdAITDIQLERLTALVFLHDA 68   Candidatus Fil...
WP_008522374   6 WAKFDKKDPTR-----WHSLLGHSADVAAVTERLLQLPL-------WRRRLsraasgsgwqSGIGALADRLCAYAALHDF 73   Jonquetella an...
WP_042088041   9 WGKYAFVSDDDq---qWHPLIDHSADVAACCEALLRQPL-------INRRMatla---gldELQPALIARLSVLAFLHDI 75   Iodidimonas ni...
WP_059060820   7 WGKLSRGPNGDvs--gWHSLFAHSADVAACVEVLLTSTI-------LNRRLaklg---glsFLSSQHIARLSVIAALHDI 74   Candidatus Pro...
3_pfamImport   1 WAKLRRNEDGEiv--sYLSLIDHSADVAAMTEALLG----------LPTIWlrlarlagkqELSVGQRRRLAALAGLHDF 68  
Q60AC8        10 WGKIRLGQNGQtd--qWLSLSQHSLDVASVFAALAELPA-------FHHKLkvs----sgiELDGIQLQRLAVIALLHDV 76   Methylococcus ...
EXI66608      21 WGKLEIERQSGav-idRLSLVDHCADVAAVFRELCTLRA-------IRRNLere----agrPLTETDLDRLAVFSFLHDL 88  
Q0AA29        24 WGKLHKGPAGEve--aWLPLADHCTDVAFVFLALCRTNA-------AHRALsqa----ighAPTPVHLERLAALAFLHDI 90   Alkalilimnicol...
WP_009280183   8 WAKTNREKIADlpddwTHPLWAHLIDVGSAAQVLWDNFLPAslkqkMADALg---------MTIDEAGRFLSIWIGLHDL 78   Fibrisoma limi

4Q2C_A       106 GKASPAFQLQLRPeqgrelVARRLRDAGLP----LfnARAPHGTISANVletvlad------------------------ 157  Thermobaculum ...
WP_076605316  69 GKLHPGFQARGWP------GESWGV------------NPHGHVHEGLEIflandgvanlpl---------------arsl 115  Candidatus Fil...
WP_008522374  74 SKLSAQFRLKKEK------DQHGDFY-----------KGVDHITTACDLvlrmdqeaayrgk------------------ 118  Jonquetella an...
WP_042088041  76 GKANRGFQYKVLP------CSKS--------------PRAGHVRELYWLfnpldalssqaye-------------alrmg 122  Iodidimonas ni...
WP_059060820  75 GKFNSGFQAKCDL------SLRS--------------KWEGHQKPILDLfgsqvkeegllyea------------ldlek 122  Candidatus Pro...
3_pfamImport  69 GKANHGFQNKALD------RDGRQSv-----------PRAGHVGPAMAIllgdegggsldittrlkdrlysmldveilad 131 
Q60AC8        77 GKANLGFQDKVFD------AKA---------------PRAGHVRELAPLfdapelceafata-------------ldlde 122  Methylococcus ...
EXI66608      89 GKCNAGFQAKAIP------SAK---------------DVAGHVREVAALffdedvrvracevl------------rleem 135 
Q0AA29        91 GKCNHGFQAKARR------EPR---------------DTAGHVHEISALlydpdlqkrllds-------------lgfde 136  Alkalilimnicol...
WP_009280183  79 GKGIPNFQGMHAP------SQQKLTDAGLIfherP--NRLHHGHASIAIvwrwlra------------------------ 126  Fibrisoma limi

4Q2C_A       158 --vfglsgRSARWVAFAVGGHHG-FvPSYDEVRRDLDQQAVGWGXw----------------------dAAREVLLCRLA 212  Thermobaculum ...
WP_076605316 116 hidslvgwGIAESLLRAVISHHG-R-PARNQVRNLSDAKQcwrs----------------------rgpYDLEAVGQEMG 171  Candidatus Fil...
WP_008522374 119 ipelvdwdcddsvFLRILLSHHGrT-PSRKKLrlhwpllwpda---------------rkdapewtaleELRQSVKRWFP 182  Jonquetella an...
WP_042088041 123 eiaswfgdAAGYALLIAAISHHG-A-PWKSDDEAGVRSWWCAddhydp----------------mqtlrDMGDHLAPWFP 184  Iodidimonas ni...
WP_059060820 123 mlswafdqEPMLRLIIATICHHG-K-PLICTSNPQtylwkpfng-----------------lnpfeglkMLRHFTQAWFA 183  Candidatus Pro...
3_pfamImport 132 wceeevagEGLANLMTALFAHHGsL-PKSTVVEPALWEStdvydp-------------------laavgELTAALRRWFP 191 
Q60AC8       123 iadwfdppDSIEQFLLAAWSHHG-A-PVRFQTGDQTGNYYLARtrwwradat---------rdpmqavaELMRIAKQAFP 191  Methylococcus ...
EXI66608     136 adwltnpeTDLPRILLAAVSHHG-Q-PAFTFDLDGAIQIDRHarywqkngd----------ydpfvalaHLTQMARSAFP 203 
Q0AA29       137 iaswfddaEGTLGMLLASISHHG-K-PIKLDHTETNRYrrywlprdg--------------idpledltNLTLTVRQAFP 200  Alkalilimnicol...
WP_009280183 127 --kdlpfdTLLDATAACVGIHHG---------------KLCHSDCweevaedekpnavlgneewkraqlDLAEAVFTAWG 189  Fibrisoma limi

4Q2C_A       213 dALGLPGSSRPT-------VESTPDAFXLAGLVSVADWIGSNeEYF 251  Thermobaculum terrenum ATCC BAA-798
WP_076605316 172 rIMCQWFPAAFEhggtelpCDNGQFEHLICGLTTLADWLGSSaQWF 217  Candidatus Filomicrobium marinum
WP_008522374 183 kAWGTDERM----------PQAPLLGHFFAGVLMLADWIGSTeYFF 218  Jonquetella anthropi
WP_042088041 185 dAFQPCTSF----------EAPSAFQHAFAGLVMLADWLGSDrGLF 220  Iodidimonas nitroreducens
WP_059060820 184 eAFIAEGDVL---------PSNSEFHHGFAGVVMLADWMGSTvKFF 220  Candidatus Protochlamydia naegleriophila
3_pfamImport 192 dAFAPDVEQV---------PTSPRFLHAFAGLVMLADWLGSDvSRF 228 
Q60AC8       192 dAFKRGVARI---------PGRARLQHRFAGLVMLADWLGSHqAFF 228  Methylococcus capsulatus
EXI66608     204 eAFQGWSEPM---------AWTRPLEHRFAGLVMLADWLGSHrEAF 240 
Q0AA29       201 qAFTGDASPL---------SPTPELQHRFAGLVMLADWIGSHeGFF 237  Alkalilimnicola ehrlichii MLHE-1
WP_009280183 190 aDWPDLSRFESIgg---pnDAWPDWLMAFAGWATLADWLGSMqRCY 232  Fibrisoma limi
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