Conserved Protein Domain Family
DNA_pol_D_N
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pfam18018: DNA_pol_D_N (This model is not part of the current CDD release)
DNA polymerase delta subunit OB-fold domain
The eukaryotic DNA polymerase delta (Pol delta) participates in genome replication, homologous recombination, DNA repair and damage tolerance. Human Pol delta consists of four subunits: p125, p50, p66 and p12. The first three subunits correspond to the three subunits of S. cerevisiae Pol delta. p50 serves as a scaffold for the assembly of Pol delta by interacting simultaneously with all of the other three subunits. This entry corresponds to the OB fold domain found in the p50 subunit.
Links
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Statistics
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PSSM-Id: 523082
Aligned: 72 rows
Threshold Bit Score: 85.7164
Created: 19-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_014570241  73 QYANIYFIRLTQLVPRVLARARRRWlles---pgnsP---Rakkskiksdaedsqfnrfttelllhqngnsdygtqsstt 146
XP_001315040  20 QFFNIYQDRLKQLRPLIESQVEGVL------------------------------------------------------- 44 
A0E2K0        51 QYCNIYSARYLNLVKRFQIDSEDPQ-----------F------------------------------------------- 76  Paramecium tetr...
XP_024331001  11 QYNNTYKIRLVTLRPLISKPQSIDI------------------------------------------------------- 35 
XP_007604536   9 QYNISYITRYNRMRELIMSNPSISE-----------Ys-lP--------------------------------------- 37 
EED43748      14 QYNENYQYRFKVLSNYIFLPKNIDi---------------P--------------------------------------- 39 
EJW03455      25 QYNKIYIARLKNITPVITVKILNDHkydnc-fiadiE---Sstdftlhpe------------------------------ 70 
EPR78803       7 QYYKNYRHRLAAIRPIILNNIENNTdkysfpiisslAe-iN--------------------------------------- 46 
ELQ75034      10 QYNQTYVTRLEKMRSLINLDVHDDT-----------T---I--------------------------------------- 36 
XP_001913482  25 QYGTIYFDRLKRLRPLLEISVKKVD-----------SnicI--------------------------------------- 54  Entamoeba histo...

XP_014570241 147 rgkqdsrtlqedaemdgleqdespepdyeedvkprmnrrngakkqngsgarstskiVNRVLEVQRD--ELCIVAGTIYVE 224
XP_001315040  45 --------------------------------------------------------CKQLNQMEPD--KPCTIIGVLYKN 66 
A0E2K0        77 --------------------------------------------------------IELIQKIQDQk-GTIKAIGTLFKE 99  Paramecium tetr...
XP_024331001  36 --------------------------------------------------------CNRIHDLNKQt-EKCFIIGILFIS 58 
XP_007604536  38 --------------------------------------------------------LKKLGD---DifEECIVIAILVLD 58 
EED43748      40 --------------------------------------------------------IKKIGKVN-T--ELCMIKAILFIK 60 
EJW03455      71 ------------------------------------------------nkiaksnkNRNIEALKNDnrKNLIIIGVFFLH 102
EPR78803      47 --------------------------------------------------------TTNIHGNSEQsnNNFIFVGVLFIA 70 
ELQ75034      37 --------------------------------------------------------LSNLSEASSAs-GPVAFIALLYVD 59 
XP_001913482  55 --------------------------------------------------------VEKLSHIPQG--R-VALIGTLFKK 75  Entamoeba histo...

XP_014570241 225 MKLKPSVLDEIA--IDYSIPAAPPRKYVTPgVDEVLLEDSSGRIRLI------------GT---GIEQGKwaLVTGIIVS 287
XP_001315040  67 LSSRQNILDEYK--DIGYESQAPEELTQSD-KDTLFLEDESGRVQLV------------G-----LQNNE--FVTGIVIG 124
A0E2K0       100 MKLKPYYFSQNQnkALQGRSYIHIQDYVSN-EDVCYLEDGSGRIKLQisnailclpnkkEK---IVNVSD--LVTGITLM 173 Paramecium tetr...
XP_024331001  59 SDLKTTIFDKLN--TNKKKVEFKKSTYISK-DIKYFVEDETGRIEIM------------LN---SKQKDF--LCTGMCLG 118
XP_007604536  59 SKLKFSILQMND---------PNVESYV-P-NSQLYIEDFSGKLPIV------------FSq-sFNKLSL--LCTGTVLG 112
EED43748      61 SNIKSSIFNTINq-VSNKKNNNTKEVYINS-DTKYFIEDDDCTIDIN------------FIc--DLYNNY--LITGMVLG 122
EJW03455     103 SCEKPNVFDEMK--PLYDEFAKPLYTYYGE-NVKYFIEDLKGRIEIK------------LSdkcLMEYPL--LVTGMVLG 165
EPR78803      71 A-TKPSVFFELKk-IN-----NSFEVY--T-NKIYYVEDEHTKVEVI------------FE---ENYHEI--LCTGMVLG 123
ELQ75034      60 CANKETIFDEAG----LIKKEKNVKPY--E-NFTYFVEDESCRVEVI------------FE-----PKDL--FVTGQVLG 113
XP_001913482  76 SKKIPTLLNQYKsiKSVDSISFDEDSYVDD-SDTCYLEDITSHVNLI------------ID---KDQLAH--IVSGTALA 137 Entamoeba histo...

XP_014570241 288 VLGAETATGDFEVLDL 303
XP_001315040 125 VQGVPSA-STFEVTKV 139
A0E2K0       174 IEGQIVANNIIKVEKF 189 Paramecium tetraurelia
XP_024331001 119 FIGNLK-NNIFNVEEI 133
XP_007604536 113 FVGCKIETNVFVCTDV 128
EED43748     123 FIGRC-ENGIFNCTQI 137
EJW03455     166 FVGFFDSLNIFCVNDI 181
EPR78803     124 FIASESENGIIKVKDI 139
ELQ75034     114 FIAERN-THSLTIKSV 128
XP_001913482 138 VIGELSNDSSFEIKSI 153 Entamoeba histolytica HM-1:IMSS
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